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This narrative review aims to analyze the sources, health implications, and biochemical impact of MPs derived from cigarette consumption. A literature search was conducted using databases such as PubMed, Scopus, and Google Scholar, applying strict inclusion criteria: peer-reviewed studies published between 2010 and 2025 and keywords such as \u201cmicroplastics\u201d, \u201csmoking\u201d, \u201ctobacco\u201d, \u201coxidative stress\u201d, \u201cpro-inflammatory cytokines\u201d, \u201ccell viability\u201d, \u201cregulatory policies\u201d, and \u201chealth effects\u201d. Findings indicate that MPs are present in biological samples such as blood (77% of cases), placenta (75%), lung tissue (88%), and feces (100%), demonstrating systemic human exposure. The environmental implications of improper cigarette disposal further exacerbate the global microplastic crisis. This review highlights potential mitigation strategies to reduce the health and environmental impact of cigarette-derived microplastics.<\/jats:p>","DOI":"10.3390\/jcm14113721","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:29:36Z","timestamp":1748338176000},"page":"3721","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Hidden Threat of Microplastics in Traditional Cigarettes: A Narrative Review of Health and Environmental Risks"],"prefix":"10.3390","volume":"14","author":[{"given":"Justyna","family":"\u015aniadach","sequence":"first","affiliation":[{"name":"Department of Psychiatry, The Faculty of Medicine, Medical University of Bia\u0142ystok, 15-272 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Kicman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Faculty of Medicine, Medical University of Bia\u0142ystok, 15-272 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Szymkowiak","sequence":"additional","affiliation":[{"name":"HCP Medical Center in Pozna\u0144, 61-485 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7021-5133","authenticated-orcid":false,"given":"Napoleon","family":"Waszkiewicz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Faculty of Medicine, Medical University of Bia\u0142ystok, 15-272 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"176292","DOI":"10.1016\/j.scitotenv.2024.176292","article-title":"Deconstructing contemporary disposable vapes: A material and elemental analysis","volume":"954","author":"Turner","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"012027","DOI":"10.1088\/1755-1315\/1084\/1\/012027","article-title":"Review on Recycling of Microplastics in Cigarette Butts","volume":"1084","author":"George","year":"2022","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41598-024-84784-4","article-title":"Investigating the Inflammatory Effect of Microplastics in Cigarette Butts on Peripheral Blood Mononuclear Cells","volume":"15","author":"Soltani","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.arbres.2022.04.005","article-title":"Tobacco as a Source of Microplastics. Tobacco and Environment: World No Tobacco Day 2022","volume":"58","year":"2022","journal-title":"Arch. Bronconeumol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"eadl2746","DOI":"10.1126\/science.adl2746","article-title":"Twenty Years of Microplastic Pollution Research\u2014What Have We Learned?","volume":"386","author":"Thompson","year":"2024","journal-title":"Science"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Sapru, S., Vardhan, M., Li, Q., Guo, Y., Li, X., and Saxena, D. (2020). E-Cigarettes Use in the United States: Reasons for Use, Perceptions, and Effects on Health. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-09572-x"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/nyas.12609","article-title":"Are E-cigarettes a Safe and Good Alternative to Cigarette Smoking?","volume":"1340","author":"Rom","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.drugalcdep.2019.04.011","article-title":"The Rise of E-Cigarettes, Pod Mod Devices, and JUUL among Youth: Factors Influencing Use, Health Implications, and Downstream Effects","volume":"201","author":"Fadus","year":"2019","journal-title":"Drug Alcohol. Depend."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Znyk, M., Jurewicz, J., and Kaleta, D. (2021). Exposure to Heated Tobacco Products and Adverse Health Effects, a Systematic Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18126651"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tree.2021.10.001","article-title":"The Ecological Impacts of Discarded Cigarette Butts","volume":"37","author":"Green","year":"2022","journal-title":"Trends Ecol. Evol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"116478","DOI":"10.1016\/j.marpolbul.2024.116478","article-title":"Coastal Plastic Pollution: A Global Perspective","volume":"203","author":"Costa","year":"2024","journal-title":"Mar. Pollut. Bull."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"144165","DOI":"10.1016\/j.scitotenv.2020.144165","article-title":"Cigarette Butts as a Microfiber Source with a Microplastic Level of Concern","volume":"762","author":"Belzagui","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"134455","DOI":"10.1016\/j.scitotenv.2019.134455","article-title":"Environmental Exposure to Microplastics: An Overview on Possible Human Health Effects","volume":"702","author":"Prata","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"168946","DOI":"10.1016\/j.scitotenv.2023.168946","article-title":"The Potential Toxicity of Microplastics on Human Health","volume":"912","author":"Zhao","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"154025","DOI":"10.1016\/j.scitotenv.2022.154025","article-title":"Environmental Health Impacts of Microplastics Exposure on Structural Organization Levels in the Human Body","volume":"825","author":"Yang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Inam, \u00d6. Impact of Microplastics on Female Reproductive Health: Insights from Animal and Human Experimental Studies: A Systematic Review. Arch. Gynecol. Obstet., 2025.","DOI":"10.1007\/s00404-024-07929-w"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100071","DOI":"10.1016\/j.hazl.2022.100071","article-title":"Ingested Microplastics: Do Humans Eat One Credit Card per Week?","volume":"3","author":"Pletz","year":"2022","journal-title":"J. Hazard. Mater. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"104147","DOI":"10.1016\/j.ebiom.2022.104147","article-title":"Microplastics Detected in Cirrhotic Liver Tissue","volume":"82","author":"Horvatits","year":"2022","journal-title":"eBioMedicine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.alcohol.2014.04.003","article-title":"Salivary Alcohol Dehydrogenase in Non-Smoking and Smoking Alcohol-Dependent Persons","volume":"48","author":"Waszkiewicz","year":"2014","journal-title":"Alcohol"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wang, Y.-F., Wang, X.-Y., Chen, B.-J., Yang, Y.-P., Li, H., and Wang, F. (2025). Impact of Microplastics on the Human Digestive System: From Basic to Clinical. World J. Gastroenterol., 31.","DOI":"10.3748\/wjg.v31.i4.100470"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"170962","DOI":"10.1016\/j.scitotenv.2024.170962","article-title":"Microplastic-Mediated New Mechanism of Liver Damage: From the Perspective of the Gut-Liver Axis","volume":"919","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e24355","DOI":"10.1016\/j.heliyon.2024.e24355","article-title":"Effect of Microplastics Deposition on Human Lung Airways: A Review with Computational Benefits and Challenges","volume":"10","author":"Saha","year":"2024","journal-title":"Heliyon"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"106061","DOI":"10.1016\/j.isci.2023.106061","article-title":"Recent Insights into Uptake, Toxicity, and Molecular Targets of Microplastics and Nanoplastics Relevant to Human Health Impacts","volume":"26","author":"Khan","year":"2023","journal-title":"iScience"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Lu, K., Zhan, D., Fang, Y., Li, L., Chen, G., Chen, S., and Wang, L. (2022). Microplastics, Potential Threat to Patients with Lung Diseases. Front. Toxicol., 4.","DOI":"10.3389\/ftox.2022.958414"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1021\/acs.chemrestox.0c00486","article-title":"Exposure of Human Lung Cells to Polystyrene Microplastics Significantly Retards Cell Proliferation and Triggers Morphological Changes","volume":"34","author":"Goodman","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"154907","DOI":"10.1016\/j.scitotenv.2022.154907","article-title":"Detection of Microplastics in Human Lung Tissue Using \u03bcFTIR Spectroscopy","volume":"831","author":"Jenner","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12989-024-00592-8","article-title":"Investigation of Pulmonary Inflammatory Responses Following Intratracheal Instillation of and Inhalation Exposure to Polypropylene Microplastics","volume":"21","author":"Tomonaga","year":"2024","journal-title":"Part Fibre Toxicol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/jocd.16167","article-title":"Microplastics in Dermatology: Potential Effects on Skin Homeostasis","volume":"23","author":"Aristizabal","year":"2024","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_29","first-page":"122","article-title":"Human Skin and Micro- and Nanoplastics: A Mini-Review","volume":"9","author":"Marelis","year":"2024","journal-title":"MOJ Eco Environ. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Dzier\u017cy\u0144ski, E., Gawlik, P.J., Pu\u017aniak, D., Flieger, W., J\u00f3\u017awik, K., Teresi\u0144ski, G., Forma, A., Wdowiak, P., Baj, J., and Flieger, J. (2024). Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review. Cancers, 16.","DOI":"10.3390\/cancers16213703"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1007\/s12013-024-01436-0","article-title":"Microplastics\u2014A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms","volume":"82","author":"Kumar","year":"2024","journal-title":"Cell Biochem. Biophys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12943-025-02230-z","article-title":"The Micro(Nano)Plastics Perspective: Exploring Cancer Development and Therapy","volume":"24","author":"Deng","year":"2025","journal-title":"Mol. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"173177","DOI":"10.1016\/j.scitotenv.2024.173177","article-title":"The Hidden Threat: Unraveling the Impact of Microplastics on Reproductive Health","volume":"935","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zurub, R.E., Cariaco, Y., Wade, M.G., and Bainbridge, S.A. (2024). Microplastics Exposure: Implications for Human Fertility, Pregnancy and Child Health. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1330396"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"15579883221096549","DOI":"10.1177\/15579883221096549","article-title":"Microplastics May Be a Significant Cause of Male Infertility","volume":"16","author":"Zhang","year":"2022","journal-title":"Am. J. Mens. Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"166258","DOI":"10.1016\/j.scitotenv.2023.166258","article-title":"Adverse Effects of Microplastics and Nanoplastics on the Reproductive System: A Comprehensive Review of Fertility and Potential Harmful Interactions","volume":"903","author":"Hong","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12958-024-01314-7","article-title":"Concerning Influences of Micro\/Nano Plastics on Female Reproductive Health: Focusing on Cellular and Molecular Pathways from Animal Models to Human Studies","volume":"22","author":"Balali","year":"2024","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"D\u2019Angelo, S., and Meccariello, R. (2021). Microplastics: A Threat for Male Fertility. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18052392"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1515\/mr-2024-0069","article-title":"Microplastic Exposure Is Associated with Male Reproductive Health","volume":"4","author":"Liu","year":"2024","journal-title":"Med. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/tobaccocontrol-2016-052931","article-title":"Association of Metals (Cd, Fe, As, Ni, Cu, Zn and Mn) with Cigarette Butts in Northern Part of the Persian Gulf","volume":"26","author":"Dobaradaran","year":"2017","journal-title":"Tob. Control"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"115286","DOI":"10.1016\/j.envpol.2020.115286","article-title":"Smoked Cigarette Butt Leachate Impacts Survival and Behaviour of Freshwater Invertebrates","volume":"266","author":"Green","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.wasman.2018.09.038","article-title":"Cigarette Butts: A Small but Hazardous Waste, According to European Regulation","volume":"82","author":"Rebischung","year":"2018","journal-title":"Waste Manag."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Branka, B., and Sever \u0160kapin, A. (2023, January 9). Weathering Effects on Cellulose Acetate Microplastics from Discarded Cigarette Butts. Proceedings of the Socratic Lectures 10\u2014Part I, Ljubljana, Slovenia.","DOI":"10.55295\/PSL.2024.I21"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.chemosphere.2017.11.158","article-title":"Nano-Litter from Cigarette Butts: Environmental Implications and Urgent Consideration","volume":"194","author":"Chevalier","year":"2018","journal-title":"Chemosphere"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"107124","DOI":"10.1016\/j.addbeh.2021.107124","article-title":"E-Cigarette Use and Change in Plans to Quit Cigarette Smoking among Adult Smokers in the United States: Longitudinal Findings from the PATH Study 2014\u20132019","volume":"124","author":"Kasza","year":"2022","journal-title":"Addict. Behav."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"107173","DOI":"10.1016\/j.envint.2022.107173","article-title":"Nanoplastics Affect the Inflammatory Cytokine Release by Primary Human Monocytes and Dendritic Cells","volume":"163","author":"Weber","year":"2022","journal-title":"Environ. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10565-013-9265-y","article-title":"Nano-sized and micro-sized polystyrene particles affect phagocyte function","volume":"30","author":"Prietl","year":"2014","journal-title":"Cell Biol. Toxicol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"150817","DOI":"10.1016\/j.scitotenv.2021.150817","article-title":"Microglial phagocytosis of polystyrene microplastics results in immune alteration and apoptosis in vitro and in vivo","volume":"807","author":"Kwon","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1039\/D1EN01067K","article-title":"Multi-omics analysis reveals size-dependent toxicity and vascular endothelial cell injury induced by microplastic exposure in vivo and in vitro","volume":"9","author":"Zhang","year":"2022","journal-title":"Environ. Sci. Nano"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"158731","DOI":"10.1016\/j.scitotenv.2022.158731","article-title":"Comprehensive in vitro polymer type, concentration, and size correlation analysis to microplastic toxicity and inflammation","volume":"854","author":"Singer","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"165295","DOI":"10.1016\/j.scitotenv.2023.165295","article-title":"Polytetrafluorethylene microplastic particles mediated oxidative stress, inflammation, and intracellular signaling pathway alteration in human derived cell lines","volume":"897","author":"KC","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_52","first-page":"126","article-title":"Polystyrene nanoparticles internalization in human gastric adenocarcinoma cells","volume":"31","author":"Forte","year":"2016","journal-title":"Toxicology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"112882","DOI":"10.1016\/j.ecoenv.2021.112882","article-title":"Prolonged Oral Ingestion of Microplastics Induced Inflammation in the Liver Tissues of C57BL\/6J Mice through Polarization of Macrophages and Increased Infiltration of Natural Killer Cells","volume":"227","author":"Zhao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"126788","DOI":"10.1016\/j.chemosphere.2020.126788","article-title":"Effects of Bisphenol A and Nanoscale and Microscale Polystyrene Plastic Exposure on Particle Uptake and Toxicity in Human Caco-2 Cells","volume":"254","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.chemosphere.2019.01.056","article-title":"Size-Dependent Effects of Polystyrene Microplastics on Cytotoxicity and Efflux Pump Inhibition in Human Caco-2 Cells","volume":"221","author":"Wu","year":"2019","journal-title":"Chemosphere"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.envres.2017.08.043","article-title":"Cytotoxic Effects of Commonly Used Nanomaterials and Microplastics on Cerebral and Epithelial Human Cells","volume":"159","author":"Schirinzi","year":"2017","journal-title":"Environ. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Saenen, N.D., Witters, M.S., Hantoro, I., Tejeda, I., Ethirajan, A., Van Belleghem, F., and Smeets, K. (2023). Polystyrene Microplastics of Varying Sizes and Shapes Induce Distinct Redox and Mitochondrial Stress Responses in a Caco-2 Monolayer. Antioxidants, 12.","DOI":"10.3390\/antiox12030739"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/07482337211065832","article-title":"Differences in Sensitivity of Human Lymphocytes and Fish Lymphocytes to Polyvinyl Chloride Microplastic Toxicity","volume":"38","author":"Salimi","year":"2022","journal-title":"Toxicol. Ind. Health"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"127871","DOI":"10.1016\/j.jhazmat.2021.127871","article-title":"The Nephrotoxic Potential of Polystyrene Microplastics at Realistic Environmental Concentrations","volume":"427","author":"Chen","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"150328","DOI":"10.1016\/j.scitotenv.2021.150328","article-title":"Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids","volume":"806","author":"Cheng","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"108171","DOI":"10.1016\/j.envint.2023.108171","article-title":"Low-Dose of Polystyrene Microplastics Induce Cardiotoxicity in Mice and Human-Originated Cardiac Organoids","volume":"179","author":"Zhou","year":"2023","journal-title":"Environ. Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"132714","DOI":"10.1016\/j.chemosphere.2021.132714","article-title":"The Potential Effects of Microplastic Pollution on Human Digestive Tract Cells","volume":"291","author":"Zhang","year":"2022","journal-title":"Chemosphere"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s40572-018-0206-z","article-title":"Microplastics in Seafood and the Implications for Human Health","volume":"5","author":"Smith","year":"2018","journal-title":"Curr. Envir Health Rep."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Li, J., Huang, F., Zhang, G., Zhang, Z., and Zhang, X. (2023). Separation and Flow Cytometry Analysis of Microplastics and Nanoplastics. Front. Chem., 11.","DOI":"10.3389\/fchem.2023.1201734"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"453","DOI":"10.7326\/M19-0618","article-title":"Detection of Various Microplastics in Human Stool: A Prospective Case Series","volume":"171","author":"Schwabl","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Jenner, L.C., Sadofsky, L.R., Danopoulos, E., Chapman, E., White, D., Jenkins, R.L., and Rotchell, J.M. (2022). Outdoor Atmospheric Microplastics within the Humber Region (United Kingdom): Quantification and Chemical Characterisation of Deposited Particles Present. Atmosphere, 13.","DOI":"10.3390\/atmos13020265"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"106274","DOI":"10.1016\/j.envint.2020.106274","article-title":"Plasticenta: First Evidence of Microplastics in Human Placenta","volume":"146","author":"Ragusa","year":"2021","journal-title":"Environ. Int."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Borgatta, M., and Breider, F. (2024). Inhalation of Microplastics\u2014A Toxicological Complexity. Toxics, 12.","DOI":"10.3390\/toxics12050358"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"107199","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and Quantification of Plastic Particle Pollution in Human Blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int."},{"key":"ref_70","unstructured":"(2025, May 19). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/tobacco."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"113429","DOI":"10.1016\/j.marpolbul.2022.113429","article-title":"The Past, Present, and Future of Plastic Pollution","volume":"176","author":"Williams","year":"2022","journal-title":"Mar. Pollut. Bull."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"170541","DOI":"10.1016\/j.scitotenv.2024.170541","article-title":"Impacts of Polypropylene Microplastics on the Distribution of Cadmium, Enzyme Activities, and Bacterial Community in Black Soil at the Aggregate Level","volume":"917","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"\u015aniadach, J., Kicman, A., Michalska-Falkowska, A., Jo\u0144czyk, K., and Waszkiewicz, N. (2025). Changes in Concentration of Selected Biomarkers of Exposure in Users of Classic Cigarettes, E-Cigarettes, and Heated Tobacco Products\u2014A Narrative Review. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26051796"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/2211-5463.13120","article-title":"From Plastics to Microplastics and Organisms","volume":"11","author":"Bajt","year":"2021","journal-title":"FEBS Open Bio"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"109672","DOI":"10.1016\/j.drugalcdep.2022.109672","article-title":"Varenicline and Related Interventions on Smoking Cessation: A Systematic Review and Network Meta-Analysis","volume":"241","author":"Guo","year":"2022","journal-title":"Drug Alcohol. Depend."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1177\/1524839916651400","article-title":"Examining the Effectiveness of the Smoking Prevention Program \u201cI Do Not Smoke, I Exercise\u201d in Elementary and Secondary School Settings","volume":"17","author":"Kolovelonis","year":"2016","journal-title":"Health Promot. Pract."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/tobaccocontrol-2018-054654","article-title":"Awareness and Interest in IQOS Heated Tobacco Products among Youth in Canada, England and the USA","volume":"29","author":"Czoli","year":"2020","journal-title":"Tob. Control"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"201","DOI":"10.7888\/juoeh.39.201","article-title":"Comparison of Chemicals in Mainstream Smoke in Heat-Not-Burn Tobacco and Combustion Cigarettes","volume":"39","author":"Bekki","year":"2017","journal-title":"J. UOEH"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"46687","DOI":"10.1038\/srep46687","article-title":"Tissue Accumulation of Microplastics in Mice and Biomarker Responses Suggest Widespread Health Risks of Exposure","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.3390\/ijerph7103760","article-title":"Chronic cigarette smoking: Implications for neurocognition and brain neurobiology","volume":"7","author":"Durazzo","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12989-020-00358-y","article-title":"The Plastic Brain: Neurotoxicity of Micro- and Nanoplastics","volume":"17","author":"Meijer","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"ref_82","first-page":"115712","article-title":"Microplastic accumulation in the brain and its potential neurotoxic effects","volume":"225","author":"Smith","year":"2023","journal-title":"Environ. Res."},{"key":"ref_83","first-page":"112345","article-title":"Microplastics in the human brain: Emerging risks and neurotoxic effects","volume":"231","author":"Garcia","year":"2025","journal-title":"Nat. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3721\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:40:32Z","timestamp":1760031632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":83,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["jcm14113721"],"URL":"https:\/\/doi.org\/10.3390\/jcm14113721","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]}}}