{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:59:52Z","timestamp":1784829592978,"version":"3.55.0"},"reference-count":115,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease characterized by esophageal eosinophilic infiltration, leading to symptoms such as dysphagia and food impaction. Endoscopy is central to both diagnosis and management, allowing for the direct visualization of characteristic features, biopsy collection, and therapeutic interventions. Despite its diagnostic value, up to one-third of patients may present with a normal-appearing esophagus, highlighting the importance of standardized scoring systems and a systematic biopsy approach. This review explores the evolving role of endoscopy in EoE, from traditional diagnostic methods to emerging technologies such as EndoFlip\u2122 for assessing esophageal distensibility, transnasal endoscopy for non-sedated monitoring, and novel dilation techniques for fibrostenotic disease. Additionally, non-invasive biomarkers and minimally invasive tools are reshaping disease monitoring. By integrating endoscopic, histologic, and molecular approaches, future advancements may enhance diagnostic accuracy and optimize personalized treatment strategies for EoE.<\/jats:p>","DOI":"10.3390\/jcm14113756","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T11:12:57Z","timestamp":1748344377000},"page":"3756","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Endoscopic Management of Eosinophilic Esophagitis: A Narrative Review on Diagnosis and Treatment"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-4506","authenticated-orcid":false,"given":"Andrea","family":"Pasta","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"IRCCS Policlinic San Martino Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4706-1499","authenticated-orcid":false,"given":"Francesco","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"IRCCS Policlinic San Martino Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6424-079X","authenticated-orcid":false,"given":"Manuele","family":"Furnari","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"IRCCS Policlinic San Martino Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2894","authenticated-orcid":false,"given":"Edoardo Vincenzo","family":"Savarino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy"},{"name":"Gastroenterology Unit, University Hospital of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6985-5301","authenticated-orcid":false,"given":"Pierfrancesco","family":"Visaggi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Bodini","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"IRCCS Policlinic San Martino Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2585-4566","authenticated-orcid":false,"given":"Elena","family":"Formisano","sequence":"additional","affiliation":[{"name":"IRCCS Policlinic San Martino Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-6308","authenticated-orcid":false,"given":"Patrizia","family":"Zentilin","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"IRCCS Policlinic San Martino Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8526-837X","authenticated-orcid":false,"given":"Edoardo Giovanni","family":"Giannini","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"IRCCS Policlinic San Martino Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4507-8605","authenticated-orcid":false,"given":"Elisa","family":"Marabotto","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"IRCCS Policlinic San Martino Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1001\/jama.2021.14920","article-title":"Eosinophilic Esophagitis: A Review","volume":"326","author":"Muir","year":"2021","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41575-022-00691-x","article-title":"Mechanisms and Clinical Management of Eosinophilic Oesophagitis: An Overview","volume":"20","author":"Biedermann","year":"2022","journal-title":"Nat. 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