{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:16:27Z","timestamp":1790406987048,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Aparito Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Parkinson Disease (PD) is a progressive neurodegenerative disorder. Current therapeutic trials investigate treatments that can potentially modify the disease course. Testing their efficiency requires outcome assessments that are relevant to patients\u2019 daily lives, which include gait and balance. Home-based examinations may enhance patient compliance and, in addition, produce more reliable results by assessing patients more regularly in their familiar surroundings. Objective: The objective of this pilot study was to assess the feasibility of a home-based outcome assessment designed to video record the Timed up and Go (vTUG) test via a study-specific smartphone app for patients with PD. Methods: 28 patients were recruited and asked to perform at home each week a set of three consecutive vTUG tests, over a period of 12 weeks using an app. The videos were subjected to a manual review to ascertain the durations of the individual vTUG phases, as well as to identify any errors or deviations in the setup that might have influenced the result. To evaluate the usability and user-friendliness of the vTUG and app, the System Usability Scale (SUS) and User Experience Questionnaire (UEQ) were administered to patients at the study end. Results: 19 patients completed the 12-week study, 17 of which recorded 10 videos or more. A total of 706 vTUGs with complete timings were recorded. Random Forest Regression yielded \u201ctime to walk up\u201d as the most important segment of the vTUG for predicting the total time. Variance of vTUG total time was significantly higher between weeks than it was between the three consecutive vTUGs at one time point [F(254,23) = 6.50, p &lt; 0.001]. The correlation between vTUG total time and UPDRS III total score was weak (r = 0.24). The correlation between vTUG and a derived gait subscore (UPDRS III items 9\u201313) was moderate (r = 0.59). A linear mixed-effects model revealed a significant effect of patient-reported motion status on vTUG total time. Including additional variables such as UPDRS III gait subscore, footwear and chairs used further improved the model fit. Conclusions: Assessment of gait and balance by home-based vTUG is feasible. Factors influencing the read-out were identified and could be better controlled for future use and longitudinal trials.<\/jats:p>","DOI":"10.3390\/jcm14113769","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T03:52:08Z","timestamp":1748404328000},"page":"3769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Feasibility of an App-Assisted and Home-Based Video Version of the Timed Up and Go Test for Patients with Parkinson Disease: vTUG"],"prefix":"10.3390","volume":"14","author":[{"given":"Marcus","family":"Grobe-Einsler","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany"},{"name":"Center for Neurology, Department of Parkinson\u2019s Disease, Sleep and Movement Disorders, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gerdes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, TUD Dresden University of Technology, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3377-3234","authenticated-orcid":false,"given":"Tim","family":"Feige","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, TUD Dresden University of Technology, 01307 Dresden, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Maas","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-3945","authenticated-orcid":false,"given":"Clare","family":"Matthews","sequence":"additional","affiliation":[{"name":"Aparito Ltd., a wholly owned subsidiary of Eli Lilly and Company, Wrexham LL13 7YP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Mendoza Garc\u00eda","sequence":"additional","affiliation":[{"name":"Aparito Ltd., a wholly owned subsidiary of Eli Lilly and Company, Wrexham LL13 7YP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Comas Fages","sequence":"additional","affiliation":[{"name":"Aparito Ltd., a wholly owned subsidiary of Eli Lilly and Company, Wrexham LL13 7YP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Haf Davies","sequence":"additional","affiliation":[{"name":"Aparito Ltd., a wholly owned subsidiary of Eli Lilly and Company, Wrexham LL13 7YP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Klockgether","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2387-526X","authenticated-orcid":false,"given":"Bj\u00f6rn H.","family":"Falkenburger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, TUD Dresden University of Technology, 01307 Dresden, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson\u2019s disease, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"Dorsey","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40035-020-00223-0","article-title":"Parkinson\u2019s disease and translational research","volume":"9","author":"Dinter","year":"2020","journal-title":"Transl. 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