{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:09:59Z","timestamp":1791418199551,"version":"4.3.3"},"reference-count":65,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Mitochondria are essential for placental function as they regulate energy metabolism, oxidative balance, and apoptotic signaling. Increasing evidence suggests that placental mitochondrial dysfunction may play a role in the development of many poor perinatal outcomes, including preeclampsia, intrauterine growth restriction (IUGR), premature birth, and stillbirth. Nonetheless, no systematic review has thoroughly investigated this connection across human research. This study aims to consolidate evidence from human research concerning the link between placental mitochondrial dysfunction and negative birth outcomes. Methods: A systematic search of PubMed, Scopus, and Web of Science identified human research examining placental mitochondrial features (e.g., mtDNA copy number, ATP production, oxidative stress indicators) in connection with adverse pregnancy outcomes. Methodological variety resulted in narrative data extraction and synthesis. Results: Twenty-nine studies met the inclusion criteria. Mitochondrial dysfunction was consistently associated with PE, IUGR, FGR, and PTB. The most often observed outcomes included diminished mtDNA copy number, decreased ATP production, elevated reactive oxygen species (ROS), and disrupted mitochondrial dynamics, characterized by increased DRP1 and decreased MFN2. Early-onset preeclampsia and symmetric fetal growth restriction exhibited particularly severe mitochondrial abnormalities, indicating a primary placental origin of the condition. Conclusions: A significant factor contributing to adverse pregnancy outcomes is the dysfunction of placental mitochondria. The analogous molecular signatures across many disorders suggest promising avenues for developing targeted therapies aimed at improving maternal\u2013fetal health and predictive biomarkers.<\/jats:p>","DOI":"10.3390\/jcm14113838","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T04:27:58Z","timestamp":1748579278000},"page":"3838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Role of Placental Mitochondrial Dysfunction in Adverse Perinatal Outcomes: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-7619","authenticated-orcid":false,"given":"Charalampos","family":"Voros","sequence":"first","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofoklis","family":"Stavros","sequence":"additional","affiliation":[{"name":"3rd Department of Obstetrics and Gynecology, Attikon Hospital, National and Kapodistrian University of Athens, Rimini 1, 12462 Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioakeim","family":"Sapantzoglou","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-6594","authenticated-orcid":false,"given":"Despoina","family":"Mavrogianni","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Anastasia","family":"Daskalaki","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-7796","authenticated-orcid":false,"given":"Marianna","family":"Theodora","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-5922","authenticated-orcid":false,"given":"Panagiotis","family":"Antsaklis","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Drakakis","sequence":"additional","affiliation":[{"name":"3rd Department of Obstetrics and Gynecology, Attikon Hospital, National and Kapodistrian University of Athens, Rimini 1, 12462 Chaidari, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8686-594X","authenticated-orcid":false,"given":"Dimitrios","family":"Loutradis","sequence":"additional","affiliation":[{"name":"Fertility Institute-Assisted Reproduction Unit, Paster 15, 11528 Athens, Greece"},{"name":"Athens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-211X","authenticated-orcid":false,"given":"Georgios","family":"Daskalakis","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.beem.2012.05.003","article-title":"Cellular and molecular mechanisms of mitochondrial function","volume":"26","author":"Osellame","year":"2012","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Walker, V. (2025). The Molecular Biology of Placental Transport of Calcium to the Human Foetus. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26010383"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Cano, A.M., Calzada-Mendoza, C.C., Estrada-Gutierrez, G., Mendoza-Ortega, J.A., and Perichart-Perera, O. (2020). Nutrients, Mitochondrial Function, and Perinatal Health. Nutrients, 12.","DOI":"10.3390\/nu12072166"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Jahan, F., Vasam, G., Green, A.E., Bainbridge, S.A., and Menzies, K.J. (2023). Placental Mitochondrial Function and Dysfunction in Preeclampsia. Int. J. Mol. Sci., 24.","DOI":"10.20944\/preprints202301.0538.v2"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3892\/ijmm.2025.5499","article-title":"Importance of STAT3 signaling in preeclampsia (Review)","volume":"55","author":"Marzioni","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1097\/HJH.0000000000003472","article-title":"Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes","volume":"41","author":"Piani","year":"2023","journal-title":"J. Hypertens."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Tossetta, G., Fantone, S., Gesuita, R., Di Renzo, G.C., Meyyazhagan, A., Tersigni, C., Scambia, G., Di Simone, N., and Marzioni, D. (2022). HtrA1 in Gestational Diabetes Mellitus: A Possible Biomarker?. Diagnostics, 12.","DOI":"10.3390\/diagnostics12112705"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Vornic, I., Buciu, V., Furau, C.G., Gaje, P.N., Ceausu, R.A., Dumitru, C.-S., Barb, A.C., Novacescu, D., Cumpanas, A.A., and Latcu, S.C. (2024). Oxidative Stress and Placental Pathogenesis: A Contemporary Overview of Potential Biomarkers and Emerging Therapeutics. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202410.0912.v1"},{"key":"ref_9","first-page":"E981","article-title":"Mitochondrial transformations in the aging human placenta","volume":"319","author":"Bartho","year":"2020","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Torres-Torres, J., Espino-Y-Sosa, S., Martinez-Portilla, R., Borboa-Olivares, H., Estrada-Gutierrez, G., Acevedo-Gallegos, S., Ruiz-Ramirez, E., Velasco-Espin, M., Cerda-Flores, P., and Ramirez-Gonzalez, A. (2024). A Narrative Review on the Pathophysiology of Preeclampsia. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147569"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/bj3480425","article-title":"Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells","volume":"348","author":"Lee","year":"2000","journal-title":"Biochem. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/1873-3468.14021","article-title":"Mitochondrial DNA copy number in human disease: The more the better?","volume":"595","author":"Filograna","year":"2021","journal-title":"FEBS Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4103\/0971-5916.154489","article-title":"Mitochondrial disorders: Challenges in diagnosis & treatment","volume":"141","author":"Thangaraj","year":"2015","journal-title":"Indian J. Med. Res."},{"key":"ref_14","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bbamcr.2017.03.006","article-title":"Molecular regulation of mitochondrial dynamics in cardiac disease","volume":"1864","author":"Nan","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1093\/hmg\/ddq143","article-title":"A pivotal role for PINK1 and autophagy in mitochondrial quality control: Implications for Parkinson disease","volume":"19","author":"Chu","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Toledano, J.M., Puche-Juarez, M., Galvez-Navas, J.M., Moreno-Fernandez, J., Diaz-Castro, J., and Ochoa, J.J. (2024). Pregnancy Disorders: A Potential Role for Mitochondrial Altered Homeostasis. Antioxidants, 13.","DOI":"10.3390\/antiox13080979"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Hebert, J.F., and Myatt, L. (2021). Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches. Biochim. Biophys. Acta (BBA) Mol. Basis Dis., 1867.","DOI":"10.1016\/j.bbadis.2020.165967"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"655","DOI":"10.7754\/Clin.Lab.2012.120227","article-title":"Mitochondrial DNA copy number and oxidative DNA damage in placental tissues from gestational diabetes and control pregnancies: A pilot study","volume":"59","author":"Qiu","year":"2013","journal-title":"Clin. Lab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/EBC20160009","article-title":"Protein quality control at the mitochondrion","volume":"60","author":"Voos","year":"2016","journal-title":"Essays Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11906-022-01184-7","article-title":"Mitochondrial Dysfunction in the Pathogenesis of Preeclampsia","volume":"24","author":"Hu","year":"2022","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_22","first-page":"59","article-title":"Targeting mitochondrial quality control: New therapeutic strategies for major diseases","volume":"11","author":"Hong","year":"2024","journal-title":"Mil. Med. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/s41390-025-04021-0","article-title":"Genomics and multiomics in the age of precision medicine","volume":"97","author":"Mani","year":"2025","journal-title":"Pediatr. Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez-Aranguren, L.C., Espinosa-Gonz\u00e1lez, C.T., Gonz\u00e1lez-Ortiz, L.M., Sanabria-Barrera, S.M., Ria\u00f1o-Medina, C.E., Nu\u00f1ez, A.F., Ahmed, A., Vasquez-Vivar, J., and L\u00f3pez, M. (2018). Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.00083"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e21555","DOI":"10.1096\/fj.202002639RRR","article-title":"Maternal RND3\/RhoE deficiency impairs placental mitochondrial function in preeclampsia by modulating the PPAR\u03b3-UCP2 cascade","volume":"35","author":"Huang","year":"2021","journal-title":"FASEB J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.2147\/DMSO.S374427","article-title":"Increased Gestational Weight Gain is Associated with a Higher Risk of Offspring Adiposity Before Five Years of Age: A Population-Based Cohort Study","volume":"15","author":"Zhang","year":"2022","journal-title":"Diabetes, Metab. Syndr. Obes. Targets Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41419-018-0360-0","article-title":"Ceramide-induced BOK promotes mitochondrial fission in preeclampsia","volume":"9","author":"Ausman","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1080\/14767058.2018.1532497","article-title":"Maternal serum mitofusin-2 levels in patients with preeclampsia: The possible role of mitochondrial dysfunction in preeclampsia","volume":"33","author":"Mathyk","year":"2020","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1080\/14767058.2016.1268594","article-title":"Placental respiratory chain complex activities in high risk pregnancies","volume":"30","author":"Beyramzadeh","year":"2017","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1007\/s11010-022-04499-w","article-title":"Placental oxidative stress and monoamine oxidase expression are increased in severe preeclampsia: A pilot study","volume":"477","author":"Sturza","year":"2022","journal-title":"Mol. Cell Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.placenta.2016.12.018","article-title":"Protective proteins and telomere length in placentas from patients with pre-eclampsia in the last trimester of gestation","volume":"50","author":"Broady","year":"2017","journal-title":"Placenta"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.mito.2021.06.006","article-title":"Placental mitochondrial DNA mutational load and perinatal outcomes: Findings from a multi-ethnic pregnancy cohort","volume":"59","author":"Cowell","year":"2021","journal-title":"Mitochondrion"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"100275","DOI":"10.1016\/j.ajogmf.2020.100275","article-title":"Vascular endothelial mitochondrial oxidative stress in response to preeclampsia: A role for angiotension II type 1 autoantibodies","volume":"3","author":"Deer","year":"2021","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/s41419-018-1190-9","article-title":"Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery","volume":"9","author":"Holland","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.placenta.2024.09.005","article-title":"Mitochondrial dysfunction and oxidative stress in selective fetal growth restriction","volume":"156","author":"Hu","year":"2024","journal-title":"Placenta"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kiyokoba, R., Uchiumi, T., Yagi, M., Toshima, T., Tsukahara, S., Fujita, Y., Kato, K., and Kang, D. (2022). Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-07893-y"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.placenta.2008.09.012","article-title":"Higher Mitochondrial DNA content in human IUGR placenta","volume":"29","author":"Lattuada","year":"2008","journal-title":"Placenta"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2018.05.007","article-title":"Study of mitochondrial function in placental insufficiency","volume":"67","author":"Lefebvre","year":"2018","journal-title":"Placenta"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.preghy.2018.10.003","article-title":"Maternal serum mitochondrial DNA (mtDNA) levels are elevated in preeclampsia\u2014A matched case-control study","volume":"14","author":"Marschalek","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.placenta.2020.02.002","article-title":"Whole genome miRNA profiling revealed miR-199a as potential placental pathogenesis of selective fetal growth restriction in monochorionic twin pregnancies","volume":"92","author":"Meng","year":"2020","journal-title":"Placenta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mito.2020.08.008","article-title":"Placental mitochondrial DNA mutations and copy numbers in intrauterine growth restricted (IUGR) pregnancy","volume":"55","author":"Naha","year":"2020","journal-title":"Mitochondrion"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2020.10.002","article-title":"Mitochondrial DNA copy number variation\u2014A potential biomarker for early onset preeclampsia","volume":"23","author":"Pandey","year":"2020","journal-title":"Pregnancy Hypertens."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"18109","DOI":"10.1073\/pnas.1907548116","article-title":"Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia","volume":"116","author":"Yung","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Shi, Z., Long, W., Zhao, C., Guo, X., Shen, R., and Ding, H. (2013). Comparative proteomics analysis suggests that placental mitochondria are involved in the development of pre-eclampsia. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064351"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2297158","DOI":"10.1080\/14767058.2023.2297158","article-title":"A mitochondrial regulator protein, MNRR1, is elevated in the maternal blood of women with preeclampsia","volume":"37","author":"Suksai","year":"2024","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1007\/s43032-021-00464-y","article-title":"Placental Mitochondrial Abnormalities in Preeclampsia","volume":"28","author":"Vangrieken","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Vishnyakova, P.A., Volodina, M.A., Tarasova, N.V., Marey, M.V., Tsvirkun, D.V., Vavina, O.V., Khodzhaeva, Z.S., Kan, N.E., Menon, R., and Vysokikh, M.Y. (2016). Mitochondrial role in adaptive response to stress conditions in preeclampsia. Sci. Rep., 6.","DOI":"10.1038\/srep32410"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbacli.2017.06.002","article-title":"Alterations in antioxidant system, mitochondrial biogenesis and autophagy in preeclamptic myometrium","volume":"8","author":"Vishnyakova","year":"2017","journal-title":"BBA Clin."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0143-4004(98)90018-2","article-title":"Placental mitochondria as a source of oxidative stress in pre-eclampsia","volume":"19","author":"Wang","year":"1998","journal-title":"Placenta"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.preghy.2018.06.012","article-title":"Exploring the role of mitochondrial dysfunction in the pathophysiology of pre-eclampsia","volume":"13","author":"Williamson","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Williamson, R.D., McCarthy, F.P., Kenny, L.C., and McCarthy, C.M. (2019). Activation of a TLR9 mediated innate immune response in preeclampsia. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-42551-w"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.placenta.2021.09.003","article-title":"Hypoxic effects on the mitochondrial content and functions of the placenta in fetal growth restriction","volume":"114","author":"Xu","year":"2021","journal-title":"Placenta"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Yu, J., Guo, X., Chen, R., and Feng, L. (2016). Downregulation of Mitofusin 2 in Placenta Is Related to Preeclampsia. BioMed Res. Int., 2016.","DOI":"10.1155\/2016\/6323086"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.yexcr.2017.07.029","article-title":"Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia","volume":"359","author":"Zhou","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e1700165","DOI":"10.1002\/prca.201700165","article-title":"Proteomics Analysis Reveals Abnormal Electron Transport and Excessive Oxidative Stress Cause Mitochondrial Dysfunction in Placental Tissues of Early-Onset Preeclampsia","volume":"12","author":"Xu","year":"2018","journal-title":"Proteom. Clin. Appl."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.preghy.2016.06.004","article-title":"Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase","volume":"6","author":"Rajakumar","year":"2016","journal-title":"Pregnancy Hypertens."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mar\u00edn, R., Chiarello, D.I., Abad, C., Rojas, D., Toledo, F., and Sobrevia, L. (2020). Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia. Biochim. Biophys. Acta (BBA) Mol. Basis Dis., 1866.","DOI":"10.1016\/j.bbadis.2020.165961"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/HYPERTENSIONAHA.118.11290","article-title":"Role of Mitochondrial Dysfunction and Reactive Oxygen Species in Mediating Hypertension in the Reduced Uterine Perfusion Pressure Rat Model of Preeclampsia","volume":"72","author":"Vaka","year":"2018","journal-title":"Hypertension"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Wu, Y., Li, M., Ying, H., Gu, Y., Zhu, Y., Gu, Y., and Huang, L. (2024). Mitochondrial quality control alterations and placenta-related disorders. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1344951"},{"key":"ref_60","first-page":"E404","article-title":"Placental mitochondrial content and function in intrauterine growth restriction and preeclampsia","volume":"306","author":"Stampalija","year":"2014","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1111\/jcmm.14282","article-title":"Mitochondrial implications in human pregnancies with intrauterine growth restriction and associated cardiac remodelling","volume":"23","author":"Youssef","year":"2019","journal-title":"J. Cell Mol. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Guerby, P., Tasta, O., Swiader, A., Pont, F., Bujold, E., Parant, O., Vayssiere, C., Salvayre, R., and Negre-Salvayre, A. (2021). Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia. Redox Biol., 40.","DOI":"10.1016\/j.redox.2021.101861"},{"key":"ref_63","first-page":"210","article-title":"The Update of Fetal Growth Restriction Associated with Biomarkers","volume":"4","author":"Sun","year":"2022","journal-title":"Matern. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/bs.ircmb.2018.05.006","article-title":"Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases","volume":"340","author":"Giorgi","year":"2018","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1186\/s12967-024-05633-6","article-title":"Fetal and obstetrics manifestations of mitochondrial diseases","volume":"22","author":"Adelizzi","year":"2024","journal-title":"J. Transl. 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