{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:31:47Z","timestamp":1771641107772,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Project of Chengdu","award":["2024-YF09-00019-SN"],"award-info":[{"award-number":["2024-YF09-00019-SN"]}]},{"name":"Science and Technology Project of Chengdu","award":["2023YFS0028"],"award-info":[{"award-number":["2023YFS0028"]}]},{"name":"Science and Technology Project of Chengdu","award":["82300118"],"award-info":[{"award-number":["82300118"]}]},{"name":"Sichuan Science and Technology Agency Grant","award":["2024-YF09-00019-SN"],"award-info":[{"award-number":["2024-YF09-00019-SN"]}]},{"name":"Sichuan Science and Technology Agency Grant","award":["2023YFS0028"],"award-info":[{"award-number":["2023YFS0028"]}]},{"name":"Sichuan Science and Technology Agency Grant","award":["82300118"],"award-info":[{"award-number":["82300118"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024-YF09-00019-SN"],"award-info":[{"award-number":["2024-YF09-00019-SN"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023YFS0028"],"award-info":[{"award-number":["2023YFS0028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300118"],"award-info":[{"award-number":["82300118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Allostatic load reflects the cumulative physiological effects of chronic and repeated stress on the body and is associated with dysregulation of multiple systems. This study aimed to examine the association between the allostatic load score (ALS) and the development of delirium in intensive care unit (ICU) patients. Method: The adult patients from the Medical Information Mart for Intensive Care (MIMIC-IV) database were screened and included in this study. Allostatic load was scored by hemoglobin A1c, high-density lipoprotein, total cholesterol, systolic blood pressure, diastolic blood pressure, body mass index, C-reactive protein, and serum albumin, and varied from 0 to 8. Restricted cubic spline and multivariate logistic regression were used to assess the relationship between ALS and delirium risk in the ICU. The threshold of the ALS was determined by the decision tree approach. A sensitivity analysis was also conducted. Results: A total of 656 patients were included in the study, and the incidence of delirium was 50.6% (n = 332). In a fully adjusted restricted cubic spline model, an increase in ALS was linearly positively correlated with the occurrence of delirium in the ICU (p-overall = 0.039, p-nonlinear = 0.506). The threshold for ALS was determined to be 3. ALS \u2265 3 was associated with increased delirium rates (p &lt; 0.001), longer hospital stays (p &lt; 0.001), and higher in-hospital mortality (p = 0.002). Subgroup analyses revealed no significant interactions (all p values for interactions &gt; 0.05). Conclusions: Higher ALS was linearly associated with increased risk of ICU delirium. An ALS \u2265 3 identified patients with greater delirium incidence, longer hospital stays, and higher mortality.<\/jats:p>","DOI":"10.3390\/jcm14113916","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T03:57:18Z","timestamp":1748923038000},"page":"3916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Allostatic Load and Delirium in ICU Patients: A Retrospective Analysis of the MIMIC-IV Database"],"prefix":"10.3390","volume":"14","author":[{"given":"Yubei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuenan","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Department of Respiratory Care, West China School of Medicine and West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7072-3285","authenticated-orcid":false,"given":"Lan","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huajing","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9267-3437","authenticated-orcid":false,"given":"Fengming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, West China School of Medicine and West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"Itc49","DOI":"10.7326\/AITC202010060","article-title":"Delirium","volume":"173","author":"Mattison","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R210","DOI":"10.1186\/cc9333","article-title":"Delirium epidemiology in critical care (DECCA): An international study","volume":"14","author":"Salluh","year":"2010","journal-title":"Crit. Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1001\/jama.286.21.2703","article-title":"Delirium in mechanically ventilated patients: Validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)","volume":"286","author":"Ely","year":"2001","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2405072","DOI":"10.1080\/07853890.2024.2405072","article-title":"Delirium in the ICU: How much do we know? A narrative review","volume":"56","author":"Liu","year":"2024","journal-title":"Ann. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"106289","DOI":"10.1016\/j.psyneuen.2023.106289","article-title":"Advancing the allostatic load model: From theory to therapy","volume":"154","author":"Juster","year":"2023","journal-title":"Psychoneuroendocrinology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.psyneuen.2019.05.028","article-title":"Clinical characterization of allostatic overload","volume":"108","author":"Fava","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1001\/archinte.1993.00410180039004","article-title":"Stress and the individual. Mechanisms leading to disease","volume":"153","author":"McEwen","year":"1993","journal-title":"Arch. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000510696","article-title":"Allostatic Load and Its Impact on Health: A Systematic Review","volume":"90","author":"Guidi","year":"2021","journal-title":"Psychother. Psychosom."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1200\/JCO.23.00907","article-title":"Association Between Neighborhood Opportunity, Allostatic Load, and All-Cause Mortality in Patients with Breast Cancer","volume":"42","author":"Chen","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"pkad005","DOI":"10.1093\/jncics\/pkad005","article-title":"Allostatic load and cardiovascular outcomes in males with prostate cancer","volume":"7","author":"Stabellini","year":"2023","journal-title":"JNCI Cancer Spectr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000530691","article-title":"Allostatic Load and Endocrine Disorders","volume":"92","author":"Sonino","year":"2023","journal-title":"Psychother. Psychosom."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/STROKEAHA.124.046622","article-title":"Effects of Allostatic Load on Long-Term Survival After Stroke","volume":"56","author":"Johnson","year":"2025","journal-title":"Stroke"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13058-023-01754-w","article-title":"Association between allostatic load and breast cancer risk: A cohort study","volume":"25","author":"Guan","year":"2023","journal-title":"Breast Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s40615-016-0246-8","article-title":"Variation in the Calculation of Allostatic Load Score: 21 Examples from NHANES","volume":"4","author":"Duong","year":"2017","journal-title":"J. Racial Ethn. Health Disparities"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"111050","DOI":"10.1016\/j.jpsychores.2022.111050","article-title":"Measuring allostatic load: Approaches and limitations to algorithm creation","volume":"163","author":"Carbone","year":"2022","journal-title":"J. Psychosom. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.jagp.2013.09.005","article-title":"Neuropathogenesis of delirium: Review of current etiologic theories and common pathways","volume":"21","author":"Maldonado","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"111320","DOI":"10.1016\/j.jclinane.2023.111320","article-title":"Postoperative neurocognitive disorders: A clinical guide","volume":"92","author":"Dilmen","year":"2024","journal-title":"J. Clin. Anesth."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3233\/JAD-190015","article-title":"Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts","volume":"69","author":"Thomson","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41597-022-01899-x","article-title":"MIMIC-IV, a freely accessible electronic health record dataset","volume":"10","author":"Johnson","year":"2023","journal-title":"Sci. Data"},{"key":"ref_20","unstructured":"Johnson, A., Bulgarelli, L., Pollard, T., Gow, B., Moody, B., Horng, S., Celi, L.A., and Mark, R. (2025, March 22). MIMIC-IV (Version 3.0). PhysioNet, Available online: https:\/\/physionet.org\/content\/mimiciv\/3.0\/."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103782","DOI":"10.1016\/j.ijnurstu.2020.103782","article-title":"Diagnostic accuracy of the CAM-ICU and ICDSC in detecting intensive care unit delirium: A bivariate meta-analysis","volume":"113","author":"Chen","year":"2021","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_22","unstructured":"(2025, March 21). International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), Available online: https:\/\/archive.cdc.gov\/www_cdc_gov\/nchs\/icd\/icd9cm.htm."},{"key":"ref_23","unstructured":"(2025, May 22). International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM), Available online: https:\/\/www.cdc.gov\/nchs\/icd\/icd-10-cm\/index.html."},{"key":"ref_24","first-page":"55","article-title":"How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions","volume":"21","author":"Sapolsky","year":"2000","journal-title":"Endocr. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0026-0495(03)00295-6","article-title":"Interacting mediators of allostasis and allostatic load: Towards an understanding of resilience in aging","volume":"52","author":"McEwen","year":"2003","journal-title":"Metabolism"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neubiorev.2009.10.002","article-title":"Allostatic load biomarkers of chronic stress and impact on health and cognition","volume":"35","author":"Juster","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/jamaoto.2023.0948","article-title":"Hearing Impairment and Allostatic Load in Older Adults","volume":"149","author":"Du","year":"2023","journal-title":"JAMA Otolaryngol. Head. Neck Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"n1007","DOI":"10.1136\/bmj.n1007","article-title":"Delirium and long term cognition in critically ill patients","volume":"373","author":"Wilcox","year":"2021","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41572-020-00223-4","article-title":"Delirium","volume":"6","author":"Wilson","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"110530","DOI":"10.1016\/j.jpsychores.2021.110530","article-title":"Biomarkers in delirium: A systematic review","volume":"147","author":"Dunne","year":"2021","journal-title":"J. Psychosom. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41582-022-00698-7","article-title":"The inter-relationship between delirium and dementia: The importance of delirium prevention","volume":"18","author":"Fong","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1097\/ALN.0b013e31819b5bc2","article-title":"Executive function and depression as independent risk factors for postoperative delirium","volume":"110","author":"Smith","year":"2009","journal-title":"Anesthesiology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/0021-9681(59)90165-1","article-title":"Delirium, a syndrome of cerebral insufficiency","volume":"9","author":"Engel","year":"1959","journal-title":"J. Chronic Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jpsychores.2008.05.019","article-title":"Unravelling the pathophysiology of delirium: A focus on the role of aberrant stress responses","volume":"65","author":"Maclullich","year":"2008","journal-title":"J. Psychosom. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1523\/JNEUROSCI.0802-06.2006","article-title":"Stress increases vulnerability to inflammation in the rat prefrontal cortex","volume":"26","author":"Herrera","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.chest.2021.06.002","article-title":"How We Prevent and Treat Delirium in the ICU","volume":"160","author":"Palakshappa","year":"2021","journal-title":"Chest"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/NNR.0b013e3181ec156b","article-title":"Allostatic load and delirium in the hospitalized older adult","volume":"59","author":"Rigney","year":"2010","journal-title":"Nurs. Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3916\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:46:20Z","timestamp":1760031980000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":37,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["jcm14113916"],"URL":"https:\/\/doi.org\/10.3390\/jcm14113916","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]}}}