{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:55:27Z","timestamp":1787241327021,"version":"build-2736575974"},"reference-count":47,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Foundation for Bone and Mineral Metabolism Research (FEIOMM)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Most of the studies that have investigated bone quality in inflammatory bowel disease (IBD) have utilized dual-energy X-ray absorptiometry (DXA). We assessed the bone status of IBD adult patients using a comprehensive array of non-invasive techniques. Methods: Fifty IBD patients (30 women) and 50 healthy volunteers\u2014matched for age, gender, and body mass index\u2014were prospectively recruited. Areal bone mineral density (aBMD) at the anteroposterior and lateral spine and the proximal femur was measured by DXA, including vertebral fracture assessment (VFA). Trabecular bone score (TBS), calcaneal quantitative ultrasound (QUS), volumetric bone mineral density (vBMD), and cortical thickness were assessed in the proximal femur with 3D-DXA. A comprehensive laboratory panel of calcium metabolism and bone turnover markers was included. Results: Twenty-nine and 21 patients were diagnosed with ulcerative colitis (UC) and Crohn\u2019s disease (CD), respectively. VFA identified vertebral fractures in two IBD patients and no controls. No statistically significant differences were observed in TBS, aBMD, and vBMD between IBD and healthy controls. After excluding one predefined outlier, broadband ultrasound attenuation (BUA) showed lower values in IBD vs. controls [103.6 \u00b1 14.3 vs. 111.3 \u00b1 19.5 (p = 0.033)]. QUS analysis revealed statistically lower values in the CD group compared to controls. We found a positive correlation between all the QUS parameters with aBMD and vBMD. Conclusions: In our study of IBD subjects, most of whom had mild or quiescent disease, we did not observe significant bone quality deterioration. QUS was the only technique that showed lower values in IBD patients, especially in CD.<\/jats:p>","DOI":"10.3390\/jcm14113933","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T11:55:52Z","timestamp":1748951752000},"page":"3933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of Bone Health in Adult Patients with Inflammatory Bowel Disease: A Single-Center Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2568-4157","authenticated-orcid":false,"given":"Mar\u00eda","family":"Cort\u00e9s-Berdonces","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario Ruber Juan Bravo, 28006 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Arberas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"Department of Gastroenterology, Hospital Universitario Ruber Juan Bravo, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"Department of Radiology, Hospital Universitario Ruber Juan Bravo, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6990-0619","authenticated-orcid":false,"given":"Israel J.","family":"Thuissard","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-9840","authenticated-orcid":false,"given":"Fernando","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"Department of Endocrinology, Hospital Universitario Quir\u00f3nsalud, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5A","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a working party of the 2005 Montreal world congress of gastroenterology","volume":"19","author":"Silverberg","year":"2005","journal-title":"Can. J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1007\/s00198-018-4586-6","article-title":"Risk of fracture and low bone mineral density in adults with inflammatory bowel diseases. A systematic literature review with meta-analysis","volume":"29","author":"Szafors","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/MCG.0000000000001031","article-title":"Risk of fractures in inflammatory bowel diseases: A systematic review and meta-Analysis","volume":"53","author":"Komaki","year":"2019","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.3748\/wjg.v26.i35.5362","article-title":"Systematic review of the prevalence and development of osteoporosis or low bone mineral density and its risk factors in patients with inflammatory bowel disease","volume":"26","author":"Lo","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/ecco-jcc\/jjaa019","article-title":"Incidence, risk factors and evaluation of osteoporosis in patients with inflammatory bowel disease: A Danish population-based inception cohort with 10 years of follow-up","volume":"14","author":"Lo","year":"2020","journal-title":"J. Crohns Colitis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00198-019-05234-w","article-title":"Perspective on skeletal health in inflammatory bowel disease","volume":"31","author":"Bravenboer","year":"2020","journal-title":"Osteoporos. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/MOG.0000000000000037","article-title":"Risk factors and management of osteoporosis in inflammatory bowel disease","volume":"30","author":"Targownik","year":"2014","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1007\/s00198-017-4189-7","article-title":"Inflammatory diseases and bone fragility","volume":"28","author":"Briot","year":"2017","journal-title":"Osteoporos. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/aje\/kwf007","article-title":"Fracture risk in patients with celiac disease, Crohn\u2019s disease, and ulcerative colitis: A nationwide follow-up study of 16,416 patients in Denmark","volume":"156","author":"Vestergaard","year":"2002","journal-title":"Am. J. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.3748\/wjg.v26.i35.5343","article-title":"Updated bone mineral density status in Saudi patients with inflammatory bowel disease","volume":"26","author":"Ewid","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/gut.40.3.313","article-title":"Bone mineral density is reduced in patients with Crohn\u2019s disease but not in patients with ulcerative colitis: A population based study","volume":"40","author":"Jahnsen","year":"1997","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jocd.2013.08.003","article-title":"The official positions of the international society for clinical densitometry: Vertebral fracture assessment","volume":"16","author":"Rosen","year":"2013","journal-title":"J. Clin. Densitom."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jocd.2015.06.006","article-title":"Measurement of hip geometry\u2014Technical background","volume":"18","author":"Beck","year":"2015","journal-title":"J. Clin. Densitom."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1109\/TMI.2016.2593346","article-title":"3D-DXA: Assessing the femoral shape, the trabecular macrostructure and the cortex in 3D from DXA images","volume":"36","author":"Humbert","year":"2017","journal-title":"IEEE Trans. Med. Imaging."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/jbmr.2176","article-title":"Trabecular bone score: A noninvasive analytical method based upon the DXA image","volume":"29","author":"Silva","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1359\/jbmr.060417","article-title":"Relationship between bone quantitative ultrasound and fractures: A meta-analysis","volume":"21","author":"Palma","year":"2006","journal-title":"J. Bone Miner. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/jbmr.499","article-title":"Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: The Manitoba study","volume":"26","author":"Hans","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00198-015-3072-7","article-title":"Predictive ability of heel quantitative ultrasound for incident fractures: An individual-level meta-analysis","volume":"26","author":"McCloskey","year":"2015","journal-title":"Osteoporos. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/MEG.0000000000000997","article-title":"Decrease of trabecular bone score reflects severity of Crohn\u2019s disease: Results of a case\u2013control study","volume":"30","author":"Krajcovicova","year":"2018","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20345","DOI":"10.1038\/s41598-021-99669-z","article-title":"Assessment of bone quality with trabecular bone score in patients with inflammatory bowel disease","volume":"11","author":"Soare","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jocd.2018.05.001","article-title":"3D analysis of cortical and trabecular bone from hip DXA: Precision and trend assessment interval in postmenopausal women","volume":"22","author":"Humbert","year":"2019","journal-title":"J. Clin. Densitom."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00198-015-3344-2","article-title":"Trabecular bone score as a skeletal fragility index in acromegaly patients","volume":"27","author":"Hong","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4168\/aair.2019.11.3.343","article-title":"Trabecular bone score is more sensitive to asthma severity and glucocorticoid treatment than bone mineral density in asthmatics","volume":"11","author":"Choi","year":"2019","journal-title":"Allergy Asthma Immunol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1055\/a-0633-2814","article-title":"High serum fractalkine is associated with lower trabecular bone score in premenopausal women with Graves\u2019 disease","volume":"50","author":"Binkley","year":"2018","journal-title":"Horm. Metab. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s40618-019-01063-0","article-title":"Trabecular bone score and quantitative ultrasound measurements in the assessment of bone health in breast cancer survivors assuming aromatase inhibitors","volume":"42","author":"Catalano","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s11657-020-00770-z","article-title":"Trabecular bone score (TBS) and bone mineral density in patients with long-term therapy with warfarin","volume":"15","author":"Marques","year":"2020","journal-title":"Arch. Osteoporos."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12891-020-3092-0","article-title":"Trabecular bone scores in young HIV-infected men: A matched case-control study","volume":"21","author":"Kim","year":"2020","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Stachowska, B., Halupczok-\u017by\u0142a, J., Kuliczkowska-P\u0142aksej, J., Syrycka, J., and Bolanowski, M. (2021). Decreased trabecular bone score in patients with active endogenous Cushing\u2019s syndrome. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.593173"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Banaszkiewicz, K., Sikorska, K., Panas, D., and Sworczak, K. (2021). The role of the trabecular bone score in the assessment of osteoarticular disorders in patients with HFE-hemochromatosis: A single-center study from Poland. Genes, 12.","DOI":"10.3390\/genes12091304"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"115607","DOI":"10.1016\/j.bone.2020.115607","article-title":"Role of deteriorated bone quality in the development of osteoporosis in pheochromocytoma and paraganglioma","volume":"142","author":"Umakoshi","year":"2021","journal-title":"Bone"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11657-020-00752-1","article-title":"Bone mineral density and trabecular bone score in treatment-na\u00efve patients with non-cirrhotic hepatitis C virus infection","volume":"15","author":"Olmos","year":"2020","journal-title":"Arch. Osteoporos."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/cen.14439","article-title":"Trabecular bone score and bone mineral density in patients with long-term controlled acromegaly","volume":"95","author":"Calatayud","year":"2021","journal-title":"Clin. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Kim, E.H., Jeon, Y.K., Pak, K., Kang, T., Kim, K.E., Kim, S.J., Kim, I.J., and Kim, K. (2021). Effect of tamoxifen with or without gonadotropin-releasing hormone analog on DXA values in women with breast cancer. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-82824-x"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jocd.2020.10.008","article-title":"Trabecular bone score in children and adolescents with inflammatory bowel diseases","volume":"24","author":"Megnazi","year":"2021","journal-title":"J. Clin. Densitom."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1097\/MIB.0000000000001139","article-title":"Structural basis of bone fragility in young subjects with inflammatory bowel disease: A high-resolution pQCT study of the SWISS IBD Cohort (SIBDC)","volume":"23","author":"Pepe","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/00042737-199802000-00007","article-title":"Screening for osteoporosis in Crohn\u2019s disease. A detailed evaluation of calcaneal ultrasound","volume":"10","author":"Robinson","year":"1998","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1111\/j.1572-0241.1998.00685.x","article-title":"Calcaneal ultrasound bone densitometry in inflammatory bowel disease--a comparison with double X-ray densitometry of the lumbar spine","volume":"93","author":"Fries","year":"1998","journal-title":"Am. J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.ultrasmedbio.2007.01.003","article-title":"Discriminatory ability of calcaneal quantitative ultrasound in the assessment of bone status in patients with inflammatory bowel disease","volume":"33","author":"Turk","year":"2007","journal-title":"Ultrasound Med. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1109\/TUFFC.2019.2947755","article-title":"Mechanisms of interaction of ultrasound with cancellous bone: A review","volume":"67","author":"Wear","year":"2020","journal-title":"IEEE Trans. Ultrason. Ferroelectr. Freq. Control"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00198-023-06728-4","article-title":"Heel quantitative ultrasound (QUS) predicts incident fractures independently of trabecular bone score (TBS), bone mineral density (BMD), and FRAX: The OsteoLaus Study","volume":"34","author":"Hans","year":"2023","journal-title":"Osteoporos. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.maturitas.2019.11.008","article-title":"Trabecular bone score and bone quantitative ultrasound in Spanish postmenopausal women. The Camargo Cohort Study","volume":"132","author":"Olmos","year":"2020","journal-title":"Maturitas"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1080\/003655299750025723","article-title":"Ultrasound measurements of calcaneus for estimation of skeletal status in patients with inflammatory bowel disease","volume":"34","author":"Jahnsen","year":"1999","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Heijckmann, A.C., Dumitrescu, B., Nieuwenhuijzen Kruseman, A.C., Geusens, P., Wolffenbuttel, B.H., De Vries, J., Drent, M., and Huijberts, M.S. (2008). Quantitative ultrasound does not identify patients with an inflammatory disease at risk of vertebral deformities. BMC Musculoskelet. Disord., 9.","DOI":"10.1186\/1471-2474-9-72"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/01.MIB.0000172809.11501.f4","article-title":"Calcaneal ultrasound bone densitometry is not a useful tool to screen patients with inflammatory bowel disease at high risk for metabolic bone disease","volume":"11","author":"Schwartz","year":"2005","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jocd.2016.08.010","article-title":"The use of the fracture risk assessment (FRAX\u00ae) tool in predicting risk of fractures in patients with inflammatory bowel disease: A systematic review","volume":"20","author":"Arias","year":"2017","journal-title":"J. Clin. Densitom."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1530\/EJE-08-0429","article-title":"Bone turnover and metabolism in paediatric patients with inflammatory bowel disease treated with systemic glucocorticoids","volume":"159","author":"Vihinen","year":"2008","journal-title":"Eur. J. Endocrinol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Tulewicz-Marti, E., Szwarc, P., Wi\u0119cek, M., Lewandowski, K., Korcz, T., Cicha, M., and Rydzewska, G. (2023). Effect of intravenous iron administration on bone mineral and iron homeostasis in patients with inflammatory bowel disease\u2014Results of a prospective single-centre study. J. Pers. Med., 13.","DOI":"10.3390\/jpm13030458"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3933\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:46:43Z","timestamp":1760032003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":47,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["jcm14113933"],"URL":"https:\/\/doi.org\/10.3390\/jcm14113933","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]}}}