{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:08:55Z","timestamp":1782961735308,"version":"3.54.5"},"reference-count":10,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: Contrast-induced acute kidney injury (CI-AKI) remains a frequent and serious complication after cardiac catheterization. Sirtuin-1 (SIRT1), a NAD+-dependent deacetylase, plays a central role in renal protection against ischemia-reperfusion injury, inflammation, and vascular dysfunction. We aimed to investigate whether serum SIRT1 levels could serve as an early diagnostic biomarker for CI-AKI. Methods: This prospective case-control study included 50 patients undergoing elective percutaneous coronary intervention (PCI) for stable angina. Serum SIRT1 levels were measured at baseline, 24 h, and 72 h post-PCI. The occurrence of CI-AKI was defined by a standard rise in serum creatinine, and patients were stratified accordingly. Results: Although SIRT1 levels tended to be lower in patients who developed CI-AKI (n = 17) compared to those without (n = 33), the differences were not statistically significant at any time point (p &gt; 0.05). However, a significant between-group difference was observed in the 72-h change in SIRT1 levels (\u03940\u201372 h, p = 0.037), with a greater decline in the CI-AKI group. Multivariable logistic regression also revealed a trend-level inverse association between 72-h SIRT1 levels and CI-AKI (\u03b2 = \u22120.536, p = 0.099). Conclusions: While SIRT1 is biologically plausible as a renal protective factor, our findings suggest that serial SIRT1 measurement may offer added value as a dynamic biomarker rather than a static diagnostic tool. Confirmatory trials incorporating serial SIRT1 measurements may help translate this molecular signal into clinically actionable tools for early detection of CI-AKI.<\/jats:p>","DOI":"10.3390\/jcm14113953","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T11:55:52Z","timestamp":1748951752000},"page":"3953","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Value of Sirtuin-1 in Predicting Contrast-Induced Nephropathy After Percutaneous Coronary Intervention"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-0188","authenticated-orcid":false,"given":"Melis","family":"Ardic","sequence":"first","affiliation":[{"name":"Department of Nephrology, Bursa Yuksek Ihtisas Training and Research Hospital, 16350 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-9356","authenticated-orcid":false,"given":"Cuma Bulent","family":"Gul","sequence":"additional","affiliation":[{"name":"Departments of Nephrology, Faculty of Medicine, Bursa Uludag University, 16059 Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1097\/01.ASN.0000135969.33773.0B","article-title":"\u201cRenalism\u201d: Inappropriately low rates of coronary angiography in elderly individuals with renal insufficiency","volume":"15","author":"Chertow","year":"2004","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_2","first-page":"489","article-title":"Contrast-Associated Acute Kidney Injury: Definitions, Epidemiology, Patho-physiology, and Implications","volume":"12","author":"Vemireddy","year":"2023","journal-title":"Interv. Cardiol. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1159\/000481804","article-title":"Resveratrol Ameliorates Contrast Induced Nephropathy Through the Activation of SIRT1-PGC-1\u03b1-Foxo1 Signaling in Mice","volume":"42","author":"Hong","year":"2017","journal-title":"Kidney Blood Press. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1172\/JCI41563","article-title":"Sirt1 activation protects the mouse renal medulla from oxidative injury","volume":"120","author":"He","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s10157-011-0421-5","article-title":"Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney","volume":"15","author":"Sakao","year":"2011","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav. Res. Methods"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Gong, L., He, J., Sun, X., Li, L., Zhang, X., and Gan, H. (2020). Activation of sirtuin1 protects against ischemia\/reperfusion-induced acute kidney injury. Biomed. Pharmacother. Biomed. Pharmacother., 125.","DOI":"10.1016\/j.biopha.2020.110021"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s10522-023-10054-x","article-title":"Evaluation of potential aging biomarkers in healthy individuals: Telomerase, AGEs, GDF11\/15, sirtuin 1, NAD+, NLRP3, DNA\/RNA damage, and klotho","volume":"24","author":"Borsky","year":"2023","journal-title":"Biogerontology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.cellsig.2013.06.007","article-title":"Antagonistic crosstalk between NF-\u03baB and SIRT1 in the regulation of inflammation and metabolic disorders","volume":"25","author":"Kauppinen","year":"2013","journal-title":"Cell. Signal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41581-024-00806-4","article-title":"Sirtuins in kidney health and disease","volume":"20","author":"Perico","year":"2024","journal-title":"Nat. Rev. Nephrol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3953\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:46:53Z","timestamp":1760032013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,3]]},"references-count":10,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["jcm14113953"],"URL":"https:\/\/doi.org\/10.3390\/jcm14113953","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,3]]}}}