{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:35:00Z","timestamp":1784543700012,"version":"3.55.0"},"reference-count":21,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Pancreatic neoplasms, including adenocarcinoma, pancreatic neuroendocrine tumors (pNETs), intraductal papillary mucinous neoplasms (IPMNs), and high-grade cystic lesions, often require surgical resection as a form of curative treatment. However, comorbidities and high-risk features may preclude surgery. Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) has emerged as a minimally invasive alternative with proven cytoreductive efficacy in solid tumors. This case series evaluates the safety and efficacy of EUS-RFA in patients with various unresectable, non-metastatic pancreatic neoplasms. Methods: A retrospective review was conducted on eight patients who underwent EUS-RFA at our institutions between July 2021 and February 2025. All patients were deemed unsuitable surgical candidates due to comorbidities such as advanced age, cardiovascular disease, renal insufficiency, and COPD or due to patient resistance to surgical intervention. EUS-RFA was performed using a 19-gauge RFA needle (Taewoong Corporation). Follow-up imaging was conducted 3 to 6 months after the completion of RFA treatment. Results: All eight patients demonstrated a good to excellent response in terms of tumor size reduction. The most notable response was observed in a patient with pNET, resulting in complete resolution from 15.6 \u00d7 12.0 mm to 0.0 \u00d7 0.0 mm after two RFA treatments. Other neoplasms, including pancreatic adenocarcinoma and intraductal papillary mucinous neoplasms (IPMNs), also demonstrated significant reductions. Mild post-procedure complications, including pancreatitis and abdominal pain, were noted in three cases. Conclusions: EUS-RFA is a promising alternative for managing unresectable pancreatic neoplasms in high-risk patients. Our findings support its use across various tumor types with favorable outcomes and minimal complications, reinforcing its role in expanding therapeutic options beyond surgery.<\/jats:p>","DOI":"10.3390\/jcm14113958","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:00:49Z","timestamp":1749016849000},"page":"3958","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Efficacy of Radiofrequency Ablation in Management of Various Pancreatic Neoplasms"],"prefix":"10.3390","volume":"14","author":[{"given":"Varshita","family":"Goduguchinta","sequence":"first","affiliation":[{"name":"Franciscan Health, Olympia Fields, IL 60461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ebrahim","sequence":"additional","affiliation":[{"name":"Ascension Saint Joseph Hospital, Chicago, IL 60657, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raahi","family":"Patel","sequence":"additional","affiliation":[{"name":"Franciscan Health, Olympia Fields, IL 60461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navkiran","family":"Randhawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Medical College of Georgia, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3835-1853","authenticated-orcid":false,"given":"Ahamed","family":"Khalyfa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4240-3442","authenticated-orcid":false,"given":"Mahnoor","family":"Inamullah","sequence":"additional","affiliation":[{"name":"Southwest Gastroenterology, Division of GI Partners of Illinois, Oak Lawn, IL 60453, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahil","family":"Desai","sequence":"additional","affiliation":[{"name":"Franciscan Health, Olympia Fields, IL 60461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Ayub","sequence":"additional","affiliation":[{"name":"Silver Cross Hospital, New Lenox, IL 60451, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/pancan.2020.0013","article-title":"Primary Pancreatic Signet Ring Cell Carcinoma: A Case Report and Review of the Literature","volume":"7","author":"Campbell","year":"2021","journal-title":"J. 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