{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:18:48Z","timestamp":1767853128918,"version":"3.49.0"},"reference-count":35,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Anogenital warts (AGWs) represent the most common clinical manifestation of human papillomavirus (HPV) infection. The analysis of AGW time trends helps to investigate possible changes over time and monitor the impact of HPV vaccines on HPV-associated morbidity. Methods: AGWs diagnosed from 1991 to 2022 at a centre belonging to the Italian STI Surveillance Network were analysed in terms of their numbers and the socio-behavioural characteristics of the patients and then compared over the course of three decades. The time trends, overall and by transmission category, were investigated by joinpoint analysis. Results: In total, 9781 AGWs were diagnosed [61.9% in men who have sex with women (MSW)]. Individuals aged 25\u201334 years (36.9%), those with one recent partner (52.0%), and those with no previous STIs (87.8%) accounted for the majority of diagnoses. The HIV prevalence among individuals tested for HIV was 136\/3098 (4.4%, 95% CI: 3.7\u20135.2). AGW diagnoses showed a mild decrease from 1991 to 2004, followed by a significant increase up to 2013 (the highest peak over the entire study period) and a significant decline thereafter, until the most recent years. During 2011\u20132022, diagnoses in women who have sex with men (WSM) decreased for those aged up to 24 years\u2014the age class that could potentially have included women vaccinated against HPV. Conclusions: AGWs have declined in recent years. The decrease in the proportion of diagnoses in young WSM may reflect the female immunisation campaign in Italy. Nonetheless, there is still a need to promote vaccine uptake to reduce the AGW burden.<\/jats:p>","DOI":"10.3390\/jcm14113962","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T06:00:49Z","timestamp":1749016849000},"page":"3962","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trends of Anogenital Warts: A 32-Year Retrospective Observational Study (Italy, 1991\u20132022)"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9721-4173","authenticated-orcid":false,"given":"Eugenia","family":"Giuliani","sequence":"first","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3250-1726","authenticated-orcid":false,"given":"Maria Gabriella","family":"Don\u00e0","sequence":"additional","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Zaccarelli","sequence":"additional","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Stingone","sequence":"additional","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gianserra","sequence":"additional","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Capodieci","sequence":"additional","affiliation":[{"name":"Scientific Direction, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0944-7699","authenticated-orcid":false,"given":"Valentina","family":"Cafaro","sequence":"additional","affiliation":[{"name":"Scientific Direction, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fulgenzio","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-6560","authenticated-orcid":false,"given":"Alessandra","family":"Latini","sequence":"additional","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-8261","authenticated-orcid":false,"given":"Massimo","family":"Giuliani","sequence":"additional","affiliation":[{"name":"STI\/HIV Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hartwig, S., Syrjanen, S., Dominiak-Felden, G., Brotons, M., and Castellsagu\u00e9, X. (2012). Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: A review. BMC Cancer, 12.","DOI":"10.1186\/1471-2407-12-30"},{"key":"ref_2","unstructured":"Salfa, M.C., Ferri, M., Suligoi, B., and e la Rete Sentinella dei Centri clinici e dei Laboratori di microbiologia clinica per le Infezioni Sessualmente Trasmesse (2025, April 15). Le Infezioni Sessualmente Trasmesse: Aggiornamento dei dati dei due sistemi di sorveglianza sentinella attivi in Italia al 31 dicembre 2021. Notiziario dell\u2019Istituto Superiore di Sanit\u00e0. Volume 36; No 5; May 2023., Available online: https:\/\/www.iss.it\/documents\/20126\/6683812\/Vol.+36%2C+n.+5.pdf\/c7178c1e-667a-a0f5-134c-e22a1c30939d?t=1689688348936."},{"key":"ref_3","first-page":"33","article-title":"A new approach to estimate genital warts incidence and prevalence in the Italian general female population","volume":"20","author":"Vittori","year":"2008","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Suligoi, B., Vittori, G., Salfa, M.C., Timelli, L., Corsini, D., Fattorini, G., Mariani, L., and Genital Warts 2 (GW2) Working Group (2017). Prevalence and incidence of external genital warts in a sample of Italian general female population. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-017-2202-6"},{"key":"ref_5","unstructured":"(2025, May 27). International Human Papillomavirus Reference Center. Available online: https:\/\/www.hpvcenter.se\/human_reference_clones\/."},{"key":"ref_6","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2012). Biological agents. IARC Monogr. Eval. Carcinog. Risks Hum., 100, 1\u2013441."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1128\/JCM.37.10.3316-3322.1999","article-title":"Detection of multiple human papillomavirus types in condylomata acuminata lesions from otherwise healthy and immunosuppressed patients","volume":"37","author":"Brown","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1086\/597071","article-title":"Natural history of genital warts: Analysis of the placebo arm of 2 randomized phase III trials of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine","volume":"199","author":"Garland","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1473-3099(14)71073-4","article-title":"Population-level impact and herd effects following human papillomavirus vaccination programmes: A systematic review and meta-analysis","volume":"15","author":"Boily","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/cid\/ciw354","article-title":"Impact and Effectiveness of the Quadrivalent Human Papillomavirus Vaccine: A Systematic Review of 10 Years of Real-world Experience","volume":"16","author":"Garland","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/016327878500800301","article-title":"Twenty years of research on the quality of medical care: 1964\u20131984","volume":"8","author":"Donabedian","year":"1985","journal-title":"Eval. Health Prof."},{"key":"ref_12","unstructured":"STI Treatment Pocket European Guidelines\u2014Summary 2019 (2025, May 27). International Union Against STI (IUSTI) Europe. Available online: https:\/\/www.iusti-europe.eu\/web\/images\/guidelines\/PocketGuideline2019.pdf."},{"key":"ref_13","unstructured":"Ipsos Pride Survey 2024 (2025, April 15). A 30-Country Ipsos Global Advisor Survey. Ipsos Global Advisor., Available online: https:\/\/www.ipsos.com\/en\/pride-month-2023-9-of-adults-identify-as-lgbt."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/jdv.14311","article-title":"Epidemiology of human papillomavirus on anogenital warts in Portugal\u2014The HERCOLES study","volume":"31","author":"Azevedo","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/OLQ.0000000000000077","article-title":"Prevalence of genital warts among sexually transmitted disease clinic patients-sexually transmitted disease surveillance network, United States, January 2010 to December 2011","volume":"41","author":"Llata","year":"2014","journal-title":"Sex. Trans. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e991","DOI":"10.1093\/cid\/ciac102","article-title":"The International Sexual Health And REproductive Health during COVID-19 (I-SHARE) Study: A Multicountry Analysis of Adults from 30 Countries Prior to and During the Initial Coronavirus Disease 2019 Wave","volume":"75","author":"Tan","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/sextrans-2020-054543","article-title":"Is COVID-19 affecting the epidemiology of STIs? The experience of syphilis in Rome","volume":"97","author":"Latini","year":"2021","journal-title":"Sex. Transm. Infect."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/sextrans-2021-055250","article-title":"Continuing evidence that COVID-19 has influenced syphilis epidemiology in Rome","volume":"98","author":"Latini","year":"2022","journal-title":"Sex. Transm. Infect."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1001\/archderm.141.1.100","article-title":"Evidence of an outbreak of syphilis among men who have sex with men in Rome","volume":"141","author":"Giuliani","year":"2005","journal-title":"Arch. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/00007435-200211000-00018","article-title":"Do condoms prevent genital HPV infection, external genital warts, or cervical neoplasia? A meta-analysis","volume":"29","author":"Manhart","year":"2002","journal-title":"Sex. Transm. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/01.olq.0000140012.02703.10","article-title":"Condom use and other factors affecting penile human papillomavirus detection in men attending a sexually transmitted disease clinic","volume":"31","author":"Baldwin","year":"2004","journal-title":"Sex. Transm. Dis."},{"key":"ref_22","first-page":"454","article-title":"Effectiveness of condoms in preventing sexually transmitted infections","volume":"82","author":"Holmes","year":"2004","journal-title":"Bull. World Health Organ."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e25110","DOI":"10.1002\/jia2.25110","article-title":"Evidence of synergistic relationships between HIV and Human Papillomavirus (HPV): Systematic reviews and meta-analyses of longitudinal studies of HPV acquisition and clearance by HIV status; and of HIV acquisition by HPV status","volume":"21","author":"Looker","year":"2018","journal-title":"J. Int. AIDS Soc."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Taylor, S., Bunge, E., Bakker, M., and Castellsagu\u00e9, X. (2016). The incidence; clearance and persistence of non-cervical human papillomavirus infections: A systematic review of the literature. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1633-9"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e531","DOI":"10.1016\/S2352-3018(21)00108-9","article-title":"Epidemiology of anal human papillomavirus infection and high-grade squamous intraepithelial lesions in 29\u2009900 men according to HIV status, sexuality, and age: A collaborative pooled analysis of 64 studies","volume":"8","author":"Wei","year":"2021","journal-title":"Lancet HIV"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1136\/sextrans-2016-053035","article-title":"Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: A systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials","volume":"93","author":"Werner","year":"2017","journal-title":"Sex. Transm. Infect."},{"key":"ref_27","unstructured":"(2025, May 27). Intesa tra il Governo, le Regioni e le Provincie Autonome di Trento e Bolzano Concernente \u201cStrategie per l\u2019Offerta Attiva del Vaccino Contro l\u2019infezione da HPV in Italia\u201d del 20 Dicembre 2007. Available online: http:\/\/archivio.statoregioni.it\/Documenti\/DOC_016696_264%20csr.pdf."},{"key":"ref_28","unstructured":"(2025, May 27). Ministero della Salute-Vaccinazione Contro il Papilloma virus (HPV)\u2014Coperture Vaccinali, Available online: https:\/\/www.salute.gov.it\/new\/it\/banche-dati\/vaccinazione-contro-il-papilloma-virus-hpv-coperture-vaccinali\/."},{"key":"ref_29","unstructured":"(2024, July 01). Ministero Della Salute: Piano Nazionale Prevenzione Vaccinale; PNPV 2017\u20132019, Available online: https:\/\/www.salute.gov.it\/imgs\/C_17_pubblicazioni_2571_allegato.pdf."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6194","DOI":"10.1016\/j.vaccine.2023.08.047","article-title":"Prophylactic HPV vaccines in patients with HPV-associated diseases and cancer","volume":"41","author":"Reuschenbach","year":"2023","journal-title":"Vaccine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1016\/j.vaccine.2023.07.031","article-title":"Quadrivalent HPV vaccine effectiveness against anogenital warts: A registry-based study of 2,2 million individuals","volume":"41","author":"Orumaa","year":"2023","journal-title":"Vaccine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1177\/0956462420920142","article-title":"Could the human papillomavirus vaccine prevent recurrence of ano-genital warts? A systematic review and meta-analysis","volume":"31","year":"2020","journal-title":"Int. J. STD AIDS"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"T874","DOI":"10.1016\/j.ad.2022.08.014","article-title":"Changes in the Prevalence of Human Papillomavirus Genotypes in Genital Warts Since the Introduction of Prophylactic Vaccines","volume":"113","year":"2022","journal-title":"Actas Dermosifiliogr."},{"key":"ref_34","unstructured":"Ministero Della Salute- Direzione Generale Della Prevenzione Sanitaria Ufficio 5\u2014Prevenzione Delle Malattie Trasmissibili e Profilassi Internazionale (2025, April 15). Commento Tecnico Alle Coperture Vaccinali al 31.12.2022 per HPV. Available online: https:\/\/www.quotidianosanita.it\/allegati\/allegato1714990555.pdf."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1080\/14760584.2022.2129615","article-title":"Real-world impact and effectiveness of the quadrivalent HPV vaccine: An updated systematic literature review","volume":"21","author":"Wang","year":"2022","journal-title":"Expert. Rev. Vaccines"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3962\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:46:24Z","timestamp":1760031984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/11\/3962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,4]]},"references-count":35,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["jcm14113962"],"URL":"https:\/\/doi.org\/10.3390\/jcm14113962","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,4]]}}}