{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T23:10:51Z","timestamp":1776553851892,"version":"3.51.2"},"reference-count":20,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Although ectopic pregnancy has been extensively studied in terms of epidemiology, associated risk factors, diagnostic approaches, and treatment modalities, the data regarding its impact on the development of adverse outcomes in subsequent pregnancy remain scarce and conflicting. We aim to evaluate the adverse perinatal outcomes of women with a history of ectopic pregnancy Methods: We used the Medline (1966\u20132024), Scopus (2004\u20132024), Clinicaltrials.gov (2008\u20132024), EMBASE (1980\u20132024), Cochrane Central Register of Controlled Trials CENTRAL (1999\u20132024), and Google Scholar (2004\u20132024) databases in our primary search. All studies that evaluated the impact of prior of ectopic pregnancy on the perinatal outcomes of the subsequent pregnancy and reported rates of adverse perinatal outcomes were considered eligible for inclusion. Twelve peer-reviewed papers were considered for inclusion in our study. We enrolled a total of 2,162,731 women. Of those, 23,823 (1.1%) had a history of prior ectopic pregnancy. A total of 4 out of 12 studies provided the necessary data to be included in the metanalysis. Results: Women with a history of treated ectopic pregnancy, either medically or surgically, demonstrated increased risk of developing placental abruption, hypertensive disorders of pregnancy, and preterm birth. History of ectopic pregnancy was also positively associated with low birth weight, subsequent ectopic pregnancy, and increased risk of a subsequent emergency cesarean section. Conclusions: The meta-analysis reveals evidence that ectopic pregnancy is positively associated with adverse perinatal outcomes in subsequent pregnancy. Our findings should be considered preliminary and serve as a basis for future research as the retrieved data are scarce and cannot be deemed sufficient.<\/jats:p>","DOI":"10.3390\/jcm14124112","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T12:53:16Z","timestamp":1749559996000},"page":"4112","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Ectopic Pregnancy on the Outcomes of the Subsequent Pregnancy: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0160-7755","authenticated-orcid":false,"given":"Dimitrios","family":"Papageorgiou","sequence":"first","affiliation":[{"name":"Department of Gynecology, Athens Naval and Veterans Hospital, 11521 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioakeim","family":"Sapantzoglou","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8754-3048","authenticated-orcid":false,"given":"Eleftherios","family":"Zachariou","sequence":"additional","affiliation":[{"name":"1st Gynecology Department, Metropolitan General Hospital, 15562 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2106-5922","authenticated-orcid":false,"given":"Panagiotis","family":"Antsaklis","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-211X","authenticated-orcid":false,"given":"Georgios","family":"Daskalakis","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-1633","authenticated-orcid":false,"given":"Vasilios","family":"Pergialiotis","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.fertnstert.2019.03.019","article-title":"Ectopic pregnancy and outcomes of future intrauterine pregnancy","volume":"112","author":"Chouinard","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1023\/A:1021106032198","article-title":"Surveillance in a time of changing health care practices: Estimating ectopic pregnancy incidence in the United States","volume":"6","author":"Zane","year":"2002","journal-title":"Matern. Child Health J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10995-019-02842-0","article-title":"Trends in ectopic pregnancy diagnoses in United States emergency departments, 2006\u20132013","volume":"24","author":"Mann","year":"2020","journal-title":"Matern. Child Health J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/humrep\/des375","article-title":"Long-term reproductive outcomes in women whose first pregnancy is ectopic: A national controlled follow-up study","volume":"28","author":"Egerup","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/aogs.12377","article-title":"Improving reproductive long-term prognosis for women with a first ectopic pregnancy. A national controlled follow-up study","volume":"93","author":"Egerup","year":"2014","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1093\/humrep\/17.12.3224","article-title":"Sites of ectopic pregnancy: A 10-year population-based study of 1800 cases","volume":"17","author":"Bouyer","year":"2002","journal-title":"Hum. Reprod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jogc.2021.01.002","article-title":"Guideline No. 414: Management of pregnancy of unknown location and tubal and nontubal ectopic pregnancies","volume":"43","author":"Page","year":"2021","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists\u2019 Committee on Practice Bulletins\u2014Gynecology (2018). ACOG Practice Bulletin No. 193: Tubal ectopic pregnancy. Obstet. Gynecol., 131, e91\u2013e103.","DOI":"10.1097\/AOG.0000000000002560"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_10","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Pereson, J., Welch, V., Losos, M., and Tugwell, P. (2025, May 26). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Available online: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.reprotox.2008.11.055","article-title":"The safety of conception occurring shortly after methotrexate treatment of an ectopic pregnancy","volume":"27","author":"Svirsky","year":"2009","journal-title":"Reprod. Toxicol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Bhattacharya, S., McLernon, D.J., Lee, A.J., and Bhattacharya, S. (2012). Reproductive outcomes following ectopic pregnancy: Register-based retrospective cohort study. PLoS Med., 9.","DOI":"10.1371\/journal.pmed.1001243"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11845-016-1419-5","article-title":"The impact of expectant management, systemic methotrexate and surgery on subsequent pregnancy outcomes in tubal ectopic pregnancy","volume":"186","author":"Demirdag","year":"2017","journal-title":"Ir. J. Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ejogrb.2017.02.018","article-title":"Subsequent pregnancy outcome of tubal ectopic pregnancies treated by methotrexate and salpingectomy","volume":"212","author":"Park","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1080\/14767058.2018.1437411","article-title":"Outcomes in subsequent pregnancies after wedge resection for interstitial ectopic pregnancy: A retrospective cohort study","volume":"32","author":"Allsworth","year":"2019","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00404-021-05991-2","article-title":"Ectopic pregnancy: Perinatal outcomes of future gestations and long-term neurological morbidity of the offspring","volume":"304","author":"Roitman","year":"2021","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Ye, H., Du, T., Huang, J., Lin, J., Tang, S., Zhao, M., and Kuang, Y. (2022). Effect of previous wedge resection for interstitial pregnancy on pregnancy and neonatal outcomes following frozen-thawed embryo transfer (FET) cycles of IVF\/ICSI: A retrospective study. Reprod. Biol. Endocrinol., 20.","DOI":"10.1186\/s12958-022-00896-4"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Jin, X., Liu, M., Zhang, P., Zheng, L., and Qi, F. (2023). Subsequent fertility after cesarean scar pregnancy: A retrospective analysis. BMC Pregnancy Childbirth, 23.","DOI":"10.1186\/s12884-023-05584-8"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/aogs.12239","article-title":"Interstitial pregnancy management and subsequent pregnancy outcome","volume":"92","author":"Sagiv","year":"2013","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_20","first-page":"31","article-title":"Comparison of the pregnancy outcomes between the medical and surgical treatments in tubal ectopic pregnancy","volume":"16","author":"Yousefnezhad","year":"2018","journal-title":"Int. J. Reprod. Biomed."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/12\/4112\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:49:37Z","timestamp":1760032177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/12\/4112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":20,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["jcm14124112"],"URL":"https:\/\/doi.org\/10.3390\/jcm14124112","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]}}}