{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T22:45:41Z","timestamp":1794350741039,"version":"4.9.0"},"reference-count":39,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Premature ovarian insufficiency (POI) is a leading cause of hypoestrogenism in women under the age of 40 years and is associated with an increased risk of impaired bone health. Early diagnosis and timely hormonal intervention are essential to prevent irreversible bone loss. However, diagnostic delay is not uncommon in clinical practice. Methods: We conducted a retrospective analysis of 168 women diagnosed with POI or early menopause (EM) between 2017 and 2024 at a tertiary gynecological endocrinology unit. Bone mineral density (BMD) and T-score were assessed by dual-energy X-ray absorptiometry (DXA) at the time of diagnosis in 125 patients, of whom 116 had secondary amenorrhea. The interval between the last menstrual period (LMP) and diagnosis was used to assess the impact of diagnostic delay. The patients were further stratified by serum estradiol (E2) levels and body mass index (BMI). Results: At the time of diagnosis, 43.1% of patients had osteopenia, and 10.3% had osteoporosis. A statistically significant negative correlation was observed between time to diagnosis and BMD (r = \u22120.225, p = 0.022), with a similar trend seen for T-score (r = \u22120.211, p = 0.031). In patients with E2 \u2264 5 ng\/L, the association was stronger (BMD: r = \u22120.401, p = 0.026). Lower E2 levels tended to be associated with poorer bone health in women with a BMI &lt; 25 kg\/m2, whereas no such trend was observed in those with a higher BMI. Conclusions: Our findings indicate that diagnostic delay in POI is associated with deterioration in bone health, particularly in lean patients and those with severe hypoestrogenism. These results underscore the importance of early recognition and timely initiation of hormone therapy to preserve bone mass and reduce long-term skeletal complications.<\/jats:p>","DOI":"10.3390\/jcm14124210","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T09:51:24Z","timestamp":1749808284000},"page":"4210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence of Impaired Bone Health in Premature Ovarian Insufficiency and Early Menopause and the Impact of Time to Diagnosis"],"prefix":"10.3390","volume":"14","author":[{"given":"Szilvia","family":"Csehely","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienn","family":"Kun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina","family":"Orb\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0625-3959","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Katona","sequence":"additional","affiliation":[{"name":"Doctoral School of Informatics, University of Debrecen, 4028 Debrecen, Hungary"},{"name":"Department of Data Science and Visualization, Faculty of Informatics, University of Debrecen, 4028 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nika","family":"Orosz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fcnde","family":"Herman","sequence":"additional","affiliation":[{"name":"Assisted Reproduction Centre, Clinical Centre, University of Debrecen, Egyetem T\u00e9r 1., Nagyerdei krt. 98., 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-3935","authenticated-orcid":false,"given":"Zo\u00e1rd Tibor","family":"Krasznai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Deli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2266-2297","authenticated-orcid":false,"given":"Attila","family":"Jakab","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Meczekalski, B., Niwczyk, O., Bala, G., and Szeliga, A. (2023). Managing Early Onset Osteoporosis: The Impact of Premature Ovarian Insufficiency on Bone Health. J. Clin. Med., 12.","DOI":"10.3390\/jcm12124042"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/13697137.2020.1804547","article-title":"Premature ovarian insufficiency: An International Menopause Society White Paper","volume":"23","author":"Panay","year":"2020","journal-title":"Climacteric"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0140-6736(76)92217-0","article-title":"Long-term prevention of postmenopausal osteoporosis by oestrogen. Evidence for an increased bone mass after delayed onset of oestrogen treatment","volume":"1","author":"Lindsay","year":"1976","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/0378-5122(96)01015-8","article-title":"Estrogen and bone metabolism","volume":"23","year":"1996","journal-title":"Maturitas"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.tem.2012.03.008","article-title":"Estrogen and the skeleton","volume":"23","author":"Khosla","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Noirrit-Esclassan, E., Valera, M.-C., Tremollieres, F., Arnal, J.-F., Lenfant, F., Fontaine, C., and Vinel, A. (2021). Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041568"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e230116","DOI":"10.1530\/JOE-23-0116","article-title":"Postmenopausal osteoporosis coexisting with sarcopenia: The role and mechanisms of estrogen","volume":"259","author":"Lu","year":"2023","journal-title":"J. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1001\/jama.1941.02820220007002","article-title":"Postmenopausal Osteoporosis: Its Clinical Features","volume":"116","author":"Albright","year":"1941","journal-title":"J. Am. Med. Assoc."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nelson, L.M. (2023). The truth about 17-beta estradiol: Menopause beyond \u201cold wives\u2019 tales\u201d. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1229804"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101823","DOI":"10.1016\/j.beem.2023.101823","article-title":"Premature ovarian insufficiency, early menopause, and induced menopause","volume":"38","author":"Hamoda","year":"2024","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/13697137.2021.1917539","article-title":"New insights into the diagnosis and management of bone health in premature ovarian insufficiency","volume":"24","author":"Nguyen","year":"2021","journal-title":"Climacteric"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/humrep\/dez259","article-title":"Age at natural menopause and development of chronic conditions and multimorbidity: Results from an Australian prospective cohort","volume":"35","author":"Xu","year":"2020","journal-title":"Hum. Reprod."},{"key":"ref_13","first-page":"283","article-title":"A korai petef\u00e9szek-el\u00e9gtelens\u00e9g id\u0151ben t\u00f6rt\u00e9n\u0151 felismer\u00e9s\u00e9nek jelent\u0151s\u00e9ge","volume":"86","author":"Csehely","year":"2023","journal-title":"Magy. Noorvosok Lapja"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Committee on Gynecologic Practice (2017). Committee Opinion No. 698: Hormone Therapy in Primary Ovarian Insufficiency. Obstet. Gynecol., 129, e134\u2013e141.","DOI":"10.1097\/AOG.0000000000002044"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/gme.0b013e31804c793d","article-title":"Effect of early menopause on bone mineral density and fractures","volume":"14","author":"Gallagher","year":"2007","journal-title":"Menopause"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"The ESHRE Guideline Group on POI, Webber, L., Davies, M., Anderson, R., Bartlett, J., Braat, D., Cartwright, B., Cifkova, R., de Muinck Keizer-Schrama, S., and Hogervorst, E. (2016). ESHRE Guideline: Management of women with premature ovarian insufficiency. Hum. Reprod., 31, 926\u2013937.","DOI":"10.1093\/humrep\/dew027"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ogc.2024.08.004","article-title":"Primary Ovarian Insufficiency, Bone Health, and Other Outcomes in Adolescents","volume":"51","author":"Cipres","year":"2024","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jpeds.2010.06.054","article-title":"Age at onset of puberty predicts bone mass in young adulthood","volume":"158","author":"Gilsanz","year":"2011","journal-title":"J. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1210\/jc.2008-1878","article-title":"Bone Mineral Density in Estrogen-Deficient Young Women","volume":"94","author":"Popat","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/humrep\/deae037","article-title":"Bone health in women with premature ovarian insufficiency\/early menopause: A 23-year longitudinal analysis","volume":"39","author":"Jones","year":"2024","journal-title":"Hum. Reprod."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bachelot, A., Nicolas, C., Gricourt, S., Dulon, J., Leban, M., Golmard, J.L., and Touraine, P. (2016). Poor Compliance to Hormone Therapy and Decreased Bone Mineral Density in Women with Premature Ovarian Insufficiency. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164638"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Faienza, M.F., Ventura, A., Colucci, S., Cavallo, L., Grano, M., and Brunetti, G. (2016). Bone Fragility in Turner Syndrome: Mechanisms and Prevention Strategies. Front. Endocrinol., 7.","DOI":"10.3389\/fendo.2016.00034"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101561","DOI":"10.1016\/j.beem.2021.101561","article-title":"Hormone therapy regimens for managing the menopause and premature ovarian insufficiency","volume":"35","author":"Armeni","year":"2021","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"hoae065","DOI":"10.1093\/hropen\/hoae065","article-title":"Evidence-based guideline: Premature ovarian insufficiency","volume":"2024","author":"Panay","year":"2024","journal-title":"Hum. Reprod. Open"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1365-2265.2010.03868.x","article-title":"Physiological versus standard sex steroid replacement in young women with premature ovarian failure: Effects on bone mass acquisition and turnover","volume":"73","author":"Crofton","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1210\/jc.2015-4063","article-title":"Hormone Replacement Therapy Versus the Combined Oral Contraceptive Pill in Premature Ovarian Failure: A Randomized Controlled Trial of the Effects on Bone Mineral Density","volume":"101","author":"Cartwright","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jocd.2007.12.010","article-title":"Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: The 2007 ISCD Official Positions","volume":"11","author":"Engelke","year":"2008","journal-title":"J. Clin. Densitom."},{"key":"ref_28","first-page":"11","article-title":"Bone mineral density measurements for diagnosis of osteoporosis and the risk assessment","volume":"14","author":"Kushida","year":"2004","journal-title":"Clin. Calcium"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1007\/s00198-012-2030-x","article-title":"Osteoporosis in young adults: Pathophysiology, diagnosis, and management","volume":"23","author":"Ferrari","year":"2012","journal-title":"Osteoporos. Int."},{"key":"ref_30","unstructured":"NICE (2019). Menopause: Diagnosis and Management. NICE Guideline [NG23], National Institute for Health and Care Excellence (NICE)."},{"key":"ref_31","unstructured":"Seabold, S., and Perktold, J. (July, January 28). Statsmodels: Econometric and Statistical Modeling with Python. Proceedings of the 9th Python in Science Conference, Austin, TX, USA."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00198-015-3440-3","article-title":"The National Osteoporosis Foundation\u2019s position statement on peak bone mass development and lifestyle factors: A systematic review and implementation recommendations","volume":"27","author":"Weaver","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1359\/jbmr.071103","article-title":"Longitudinal Changes in BMD and Bone Geometry in a Population-Based Study","volume":"23","author":"Lauretani","year":"2009","journal-title":"J. Bone Miner. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11657-014-0175-2","article-title":"Body mass index is positively associated with bone mineral density in US older adults","volume":"9","author":"Lloyd","year":"2014","journal-title":"Arch. Osteoporos."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.numecd.2021.02.027","article-title":"Effect of body mass index on bone mineral density is age-specific","volume":"31","author":"Cherukuri","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e40129","DOI":"10.1097\/MD.0000000000040129","article-title":"The effect of body mass index on bone density by age distribution in women","volume":"103","author":"Yildirim","year":"2024","journal-title":"Medicine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13018-022-03161-x","article-title":"Association between obesity and bone mineral density in middle-aged adults","volume":"17","author":"Li","year":"2022","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_39","first-page":"720","article-title":"Meeting the Needs of Young Women With Secondary Amenorrhea and Spontaneous Premature Ovarian Failure","volume":"99","author":"Alzubaidi","year":"2002","journal-title":"Obstet. Gynecol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/12\/4210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:51:27Z","timestamp":1760032287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/12\/4210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,13]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["jcm14124210"],"URL":"https:\/\/doi.org\/10.3390\/jcm14124210","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,13]]}}}