{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:32:49Z","timestamp":1762929169260,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Transcatheter mitral valve edge-to-edge repair (M-TEER) reduces mitral regurgitation (MR) severity and improves symptoms, but early post-procedural assessment of left atrial pressure (LAP) remains challenging. Objectives: Investigating the impact of M-TEER on diastolic parameters and derived cutoff values to estimate post-procedural LAP. Methods: This retrospective study (n = 240) analyzed the effects of M-TEER on diastolic parameters. Cutoff values for predicting normal LAP were identified using classification tree analysis and validated with current methods for assessing LAP. Results: M-TEER increased E\/e\u2032 ratio in both normal and abnormal left ventricular ejection fraction (LVEF) groups. In normal LVEF, E wave velocity \u2264 85 cm\/s at 30 days correlated with normal LAP (98% specificity, 90% positive predictive value). In abnormal LVEF, E\/e\u2032 \u2264 14 or E wave velocity \u2264 95 cm\/s correlated with normal LAP (98%\/90% specificity, 91%\/83% positive predictive value). The validation of the proposed cutoff values with existing non-invasive methods showed 96% accuracy for normal LAP (24\/25) and 90% for elevated LAP (27\/30). Conclusions: M-TEER significantly alters diastolic parameters. Derived cutoff values based on easily obtainable diastolic measures show promise in estimating post-procedural LAP, but need further validation for clinical use.<\/jats:p>","DOI":"10.3390\/jcm14124308","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T07:04:52Z","timestamp":1750143892000},"page":"4308","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Estimating Left Atrial Pressure Using Diastolic Cutoff Values After Transcatheter Mitral Valve Edge-to-Edge Repair"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3863-4493","authenticated-orcid":false,"given":"Yoav","family":"Niv Granot","sequence":"first","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-6016","authenticated-orcid":false,"given":"Giulia","family":"Passaniti","sequence":"additional","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1888-0793","authenticated-orcid":false,"given":"Samin","family":"Sharma","sequence":"additional","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annapoorna","family":"Kini","sequence":"additional","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-4541","authenticated-orcid":false,"given":"Daniel","family":"Karlsberg","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine, NYU Langone Health, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahil","family":"Khera","sequence":"additional","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert H. L.","family":"Tang","sequence":"additional","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"},{"name":"Department of Cardiovascular Surgery, Mount Sinai Health System, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stamatios","family":"Lerakis","sequence":"additional","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy M.","family":"Safi","sequence":"additional","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J. 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