{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:12:54Z","timestamp":1776719574546,"version":"3.51.2"},"reference-count":25,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Laboratorios Liomont"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: The aim of the present study was to evaluate the efficacy and safety of etoricoxib\u2013tramadol 120 mg\/100 mg (Eto-Tr) in acute moderate-to-severe pain. Methods: Eto-Tr once a day (n = 29) or naproxen 220 mg + tramadol 50 mg (Nap-Tr) every 12 h (n = 28) were administered after a third molar extraction for three days. Pain intensity difference at 4 h (PID4) was determined as the primary outcome. In addition, total pain relief (TOTPAR), trismus control, and adverse events were addressed. Results: The population PID4 score was 0 mm (Nap-Tr IQR 13 mm; Eto-Tr IQR 35 mm; p = 0.182). No differences for PID scores were observed (1 h to 72 h). TOTPAR increased gradually from 35.71% (Nap-Tr) and 39.39% (Eto-Tr) at 4 h to 67.86% (Nap-Tr) and 58.62% (Eto-Tr) at 72 h. Sustained pain relief over time and clinically meaningful trismus reduction was also observed (Nap-Tr: 4 mm [IQR 28.10] vs. Eto-Tr: 9.8 mm [IQR 12.3], p = 0.175). Common adverse events were notified [Nap-Tr (n = 5, 19%); Eto-Tr (n = 8, 27%)]. Conclusions: The once-daily administration of Eto-Tr 120 mg\/100 mg showed similar efficacy and safety to conventional treatment in moderate-to-severe acute pain. The once-daily regimen together with a multimodal analgesia represents a suitable patient-centered alternative for pain management.<\/jats:p>","DOI":"10.3390\/jcm14124327","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T11:53:14Z","timestamp":1750161194000},"page":"4327","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of a Fixed-Dose Combination of Etoricoxib\u2013Tramadol Biphasic Tablet in Moderate-to-Severe Acute Pain: A Randomized, Double-Blind, Parallel-Group, Active-Controlled Trial"],"prefix":"10.3390","volume":"14","author":[{"given":"Tania A.","family":"Sibaja","sequence":"first","affiliation":[{"name":"Oaxaca Site Management Organization S.C., Humboldt 302, Colonia Centro, Oaxaca 68000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe A.","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Centro Oncol\u00f3gico Potosino, La Mora 139, Fraccionamiento del Parque, San Luis Potos\u00ed 78294, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazmin I.","family":"D\u00e1vila","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Aplicadas a la Neurociencia A.C., Pasteur 205, Colonia Zona Centro, Durango 34000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick M.","family":"Salinas","sequence":"additional","affiliation":[{"name":"Independent Researcher, Nicol\u00e1s Bravo Sur 712-A, Colonia Universidad, Toluca 50130, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Venegas","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Ozonoterapia RGH A.C., 31 Poniente 2523, Colonia Benito Ju\u00e1rez, Puebla 72410, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dany","family":"Batista","sequence":"additional","affiliation":[{"name":"Pharmometrica S.A de C.V., Avenida de Las Granjas 972, Azcapotzalco, Ciudad de M\u00e9xico 02230, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0946-5421","authenticated-orcid":false,"given":"Livan","family":"Delgado-Roche","sequence":"additional","affiliation":[{"name":"Laboratorios Liomont, S.A. de C.V., Adolfo L\u00f3pez Mateos 68, Colonia Cuajimalpa, Cuajimalpa de Morelos, Ciudad de M\u00e9xico 05000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104329","DOI":"10.1016\/j.drudis.2025.104329","article-title":"Molecule-rich solutions for achieving novel non-opioid analgesics","volume":"30","author":"Liu","year":"2025","journal-title":"Drug. 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