{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:30:34Z","timestamp":1792452634061,"version":"4.5.0"},"reference-count":26,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of P\u00e9cs, Medical School","award":["FK142942"],"award-info":[{"award-number":["FK142942"]}]},{"name":"University of P\u00e9cs, Medical School","award":["FK132834"],"award-info":[{"award-number":["FK132834"]}]},{"name":"University of P\u00e9cs, Medical School","award":["TKP2021-EGA-17"],"award-info":[{"award-number":["TKP2021-EGA-17"]}]},{"name":"National Research, Development, and Innovation Office (NKFIH)","award":["FK142942"],"award-info":[{"award-number":["FK142942"]}]},{"name":"National Research, Development, and Innovation Office (NKFIH)","award":["FK132834"],"award-info":[{"award-number":["FK132834"]}]},{"name":"National Research, Development, and Innovation Office (NKFIH)","award":["TKP2021-EGA-17"],"award-info":[{"award-number":["TKP2021-EGA-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Venous thromboembolism is more prevalent among patients with inflammatory bowel disease (IBD). This study aimed to identify prothrombotic hemorheological alterations in IBD. Methods: We conducted a case\u2013control study with patients with ulcerative colitis, Crohn\u2019s disease, and non-IBD control subjects. We measured hemorheological indicators including plasma viscosity (PV), whole blood viscosity (WBV), erythrocyte aggregation (EA), and erythrocyte deformability (ED). Uni- and multivariate tests were employed for analysis. Results: A total of 53 IBD patients and 77 control subjects were recruited. IBD patients showed significantly higher aggregation index (68.8% (35.3\u201383.5%) vs. 66.9% (35.2\u201383.5%), p = 0.003) and threshold shear rate (120 1\/s (55\u2013325 1\/s) vs. 110 1\/s (55\u2013325 1\/s), p &lt; 0.001), with lower aggregation half-time (1.6 s (0.6\u20137.1 s) vs. 1.8 s (0.6\u20137.1 s), p = 0.004), indicating enhanced EA. However, after adjusting for covariates, including inflammatory markers, IBD no longer predicted EA. There were no significant differences in EA. PV, WBV, and ED between the groups. Fibrinogen, rather than the Crohn\u2019s Disease Activity Index, was the strongest predictor of the outcomes. Conclusions: Our study demonstrates that IBD patients exhibit enhanced EA, predicted mainly by fibrinogen. These results confirm that inflammation plays the cardinal role in the increased tendency for venous thromboembolism in IBD.<\/jats:p>","DOI":"10.3390\/jcm14134436","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T07:42:34Z","timestamp":1750664554000},"page":"4436","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hemorheology in Inflammatory Bowel Disease: A Case\u2013Control Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7035-941X","authenticated-orcid":false,"given":"Zsolt","family":"Szak\u00e1cs","sequence":"first","affiliation":[{"name":"First Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5537-9738","authenticated-orcid":false,"given":"Be\u00e1ta","family":"Csisz\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intesive Therapy, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ty\u00e1s","family":"Nagy","sequence":"additional","affiliation":[{"name":"Saint Raphael Hospital of Zala Castle County, H-8900 Zalaegerszeg, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"T\u0151k\u00e9s-F\u00fczesi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Sarl\u00f3s","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0114-5231","authenticated-orcid":false,"given":"K\u00e1lm\u00e1n","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Szentagothai Research Centre, University of Pecs, H-7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Institute of Pancreatic Diseases, Semmelweis University, H-1083 Budapest, Hungary"},{"name":"Centre for Translational Medicine, Semmelweis University, H-1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4609-487X","authenticated-orcid":false,"given":"Hussain","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-4871","authenticated-orcid":false,"given":"Judit","family":"Bajor","sequence":"additional","affiliation":[{"name":"First Department of Medicine, Medical School, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mayocp.2018.09.013","article-title":"Mechanisms of Disease: Inflammatory Bowel Diseases","volume":"94","author":"Ramos","year":"2019","journal-title":"Mayo Clin. 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