{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:26:05Z","timestamp":1760059565414,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) represents a severe complication associated with bisphosphonate therapy commonly used in patients with osteoporosis and malignancies. Methods: This retrospective study evaluates the risk factors and clinical outcomes of BRONJ patients treated at the Oral and Maxillofacial Surgery Clinic in Ia\u015fi, Romania, with the goal of optimizing preventive and therapeutic strategies. Data from 72 BRONJ patients treated between January 2013 and December 2023 were analyzed. Results: The majority (83.3%) of patients had underlying malignancies, predominantly breast and prostate cancers. The mandible was most affected, with tooth extraction identified as the primary triggering event. Systemic comorbidities, notably arterial hypertension, diabetes mellitus, and concurrent chemotherapy, were significantly associated with increased BRONJ severity. Surgical intervention was frequently required, with sequestrectomy being the predominant procedure, reflecting advanced disease at the time of diagnosis. Conclusions: The findings underline the critical importance of early identification, preventive dental management, and a collaborative multidisciplinary approach to improve patient prognosis.<\/jats:p>","DOI":"10.3390\/jcm14134445","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T07:42:34Z","timestamp":1750664554000},"page":"4445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bisphosphonate-Related Osteonecrosis of the Jaw: A 10-Year Analysis of Risk Factors and Clinical Outcomes"],"prefix":"10.3390","volume":"14","author":[{"given":"Carmen Gabriela","family":"Stelea","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0091-8765","authenticated-orcid":false,"given":"Emilia","family":"Bologa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otilia","family":"Boi\u0219teanu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra-Lorina","family":"Platon","sequence":"additional","affiliation":[{"name":"Department of Orthodontics and Dentofacial Orthopaedics, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0218erban-Ovidiu","family":"Stelea","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1340-1418","authenticated-orcid":false,"given":"Gabriela Lumini\u021ba","family":"Gele\u021bu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezara Andreea","family":"Onic\u0103","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9772-4966","authenticated-orcid":false,"given":"Daniela","family":"\u0218ulea","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai-Liviu","family":"Ciofu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3978-5103","authenticated-orcid":false,"given":"Victor Vlad","family":"Costan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Dental Medicine, \u201cGrigore T. Popa\u201d, 16 Universitatii Str., 700115 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rugani, P., Walter, C., Kirnbauer, B., Acham, S., Begus-Nahrman, Y., and Jakse, N. (2016). Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma. Dent. J., 4.","DOI":"10.3390\/dj4040032"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.oooo.2018.09.008","article-title":"Medication-related osteonecrosis of the jaw: Definition and best practice for prevention, diagnosis, and treatment","volume":"127","author":"Mendes","year":"2019","journal-title":"Oral Surg. Oral Med. Oral Pathol. 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