{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:23:11Z","timestamp":1791490991989,"version":"4.3.4"},"reference-count":23,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2013NextGenerationEU\u2013MUR funds D.M.","award":["737\/2021"],"award-info":[{"award-number":["737\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objective: Chronic rhinosinusitis with nasal polyps is a chronic inflammatory disease with a significant impact on quality of life and is frequently associated, from a pathogenetic perspective, with type 2 inflammation. The introduction of biologic therapies has marked a turning point in the management of severe forms of the disease, offering a valuable treatment option. However, selecting the most suitable biologic agent for a specific patient remains a clinical challenge. Artificial intelligence, and, in particular, ChatGPT, has recently been proposed as a potential tool to support medical decision-making and guide therapeutic choices. To evaluate the concordance between the therapeutic recommendations provided by ChatGPT and those of a multidisciplinary expert board in selecting the most appropriate biologic therapy for CRSwNP patients, based on the analysis of their phenotype and endotype. Methods: A multicenter observational cohort study was conducted. Clinical data from 286 patients with CRSwNP were analyzed. For each case, the therapeutic choice among Dupilumab, Mepolizumab, and Omalizumab was compared between the board and ChatGPT. Concordance rates and Cohen\u2019s Kappa coefficient were calculated. Results: Overall concordance was 59.2%, with a Cohen\u2019s Kappa coefficient of 0.116. Concordance by drug was 62.8% for Dupilumab, 26.5% for Mepolizumab, and 9.1% for Omalizumab. Patients presented with severe clinical profiles, with an average Nasal Polyp Score of 6.22 and an average SNOT-22 score of 64.5. Conclusions: This study demonstrates that, despite its substantial theoretical potential, ChatGPT is currently not a reliable tool for the autonomous selection of biological therapies in patients with CRSwNP. Further studies are necessary to enhance its reliability and integration into clinical practice.<\/jats:p>","DOI":"10.3390\/jcm14134501","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T05:53:13Z","timestamp":1750917193000},"page":"4501","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["ChatGPT in the Management of Chronic Rhinosinusitis with Nasal Polyps: Promising Support or Digital Illusion? Insights from a Multicenter Observational Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7723-5514","authenticated-orcid":false,"given":"Riccardo","family":"Manzella","sequence":"first","affiliation":[{"name":"Otorhinolaryngology Unit, Biomedicine, Neuroscience and Advanced Diagnostic Department, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3414-6492","authenticated-orcid":false,"given":"Angelo","family":"Immordino","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Biomedicine, Neuroscience and Advanced Diagnostic Department, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-4596","authenticated-orcid":false,"given":"Cosimo","family":"Galletti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, University of Enna \u201cKore\u201d, 94100 Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Giammona Indaco","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Umberto I Hospital, 94100 Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Stilo","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Medical-Surgical Sciences and Advanced Technologies, University of Catania, 95131 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Messina","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Medical-Surgical Sciences and Advanced Technologies, University of Catania, 95131 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Biomedicine, Neuroscience and Advanced Diagnostic Department, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Gargano","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Biomedicine, Neuroscience and Advanced Diagnostic Department, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Frangipane","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Medical-Surgical Sciences and Advanced Technologies, University of Catania, 95131 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Giunta","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Medical-Surgical Sciences and Advanced Technologies, University of Catania, 95131 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Mariut","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Medical-Surgical Sciences and Advanced Technologies, University of Catania, 95131 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-8535","authenticated-orcid":false,"given":"Daniele","family":"Portelli","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Adult and Development Age Human Pathology, University of Messina, 98122 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Zambito","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Umberto I Hospital, 94100 Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Ferrisi","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Adult and Development Age Human Pathology, University of Messina, 98122 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ciodaro","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Adult and Development Age Human Pathology, University of Messina, 98122 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Centineo","sequence":"additional","affiliation":[{"name":"Digital Consultant Freelance, 90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Maira","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Umberto I Hospital, 94100 Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5844-9762","authenticated-orcid":false,"given":"Francesco","family":"Dispenza","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Biomedicine, Neuroscience and Advanced Diagnostic Department, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Gallina","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Biomedicine, Neuroscience and Advanced Diagnostic Department, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"La Mantia","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Medical-Surgical Sciences and Advanced Technologies, University of Catania, 95131 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Galletti","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Adult and Development Age Human Pathology, University of Messina, 98122 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Galletti","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Adult and Development Age Human Pathology, University of Messina, 98122 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Sireci","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Unit, Department of Precision Medicine in Medical, Surgical and Critical Care, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Johnson, D., Goodman, R., Patrinely, J., Stone, C., Zimmerman, E., Donald, R., Chang, S., Berkowitz, S., Finn, A., and Jahangir, E. 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