{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:27:00Z","timestamp":1760059620102,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ulsan University Industry\u2013University Cooperation Foundation","award":["2024-0454"],"award-info":[{"award-number":["2024-0454"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: The aim of this study was to evaluate whether the use of BioGlue\u00ae increases the risk of postoperative mass formation and subsequent spinal canal invasion after intradural spinal tumor surgery. Methods: After retrospectively reviewing patients who underwent intradural tumor surgery from 2018 to 2023, we evaluated mass formation as detected in postoperative MRI according to the Epidural Spinal Cord Compression (ESCC) grade. Patients were divided into two groups based on the use of BioGlue\u00ae, and we analyzed MRI postoperatively to compare the differences in ESCC grades and the incidence of symptomatic spinal canal invasion between the two groups. Additionally, we performed a logistic regression analysis to identify risk factors associated with mass formation and to explore their relationship with BioGlue\u00ae. Results: This study included a total of 153 patients, 87 in the BioGlue\u00ae and 66 in the non-BioGlue\u00ae groups. In the BioGlue\u00ae group, 18 patients had ESCC grade 2, and 11 had grade 3. Conversely, in the non-BioGlue\u00ae group, only 8 patients had ESCC grade 2, and none had grade 3 (p = 0.001). Among the cases of symptomatic spinal canal invasion, all five cases were identified in the BioGlue\u00ae group (p = 0.001). Both univariate and multivariate analyses showed that BioGlue\u00ae was a significant risk factor for spinal canal invasion (univariate: OR = 3.931, p = 0.005, multivariate: OR = 3.812, p = 0.003). Conclusions: Our findings indicated that BioGlue\u00ae was a significant risk factor for mass formation aggravating spinal canal invasion after intradural tumor surgery.<\/jats:p>","DOI":"10.3390\/jcm14134540","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T03:33:25Z","timestamp":1750995205000},"page":"4540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BioGlue\u00ae Induced Mass Formation Aggravating Spinal Canal Invasion After Intradural Tumor Surgery"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8425-4961","authenticated-orcid":false,"given":"Sun Woo","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6642-5285","authenticated-orcid":false,"given":"Sang Hyub","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Spine Center, The Leon Wiltse Memorial Hospital, Suwon 16499, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Kyung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ryong","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4055-9584","authenticated-orcid":false,"given":"Danbi","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"},{"name":"College of Nursing, Korea University, Seoul 02841, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chongman","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Industrial and Management Engineering, Myongji University, Seoul 03674, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0003-4975(02)03689-5","article-title":"BioGlue Surgical Adhesive\u2014An appraisal of its indications in cardiac surgery","volume":"74","author":"Passage","year":"2002","journal-title":"Ann. 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