{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T23:59:07Z","timestamp":1774396747936,"version":"3.50.1"},"reference-count":54,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Primary vaginal cancer is a rare gynecological condition. We present a case of complete utero-vaginal prolapse complicated by primary invasive vaginal carcinoma. To our knowledge, only a few similar cases have been reported in our region. Case Report: A 77-year-old woman, gravida two and para two, was admitted for treatment of pelvic organ prolapse. The patient reported an eight-year history of uterine bulging but had not used a pessary. The gynecological examination revealed a complete manually irreducible utero-vaginal prolapse with an ulcerative lesion on the right posterolateral vaginal wall. The histological examination diagnosed an HPV-independent keratinizing squamous cell carcinoma, grade I. Comprehensive imaging showed no evidence of metastasis. The patient underwent radical hysterectomy, bilateral adnexectomy, complete resection of the vaginal mass, and pelvic lymphadenectomy. The histopathological examination confirmed clear surgical margins. According to the International Federation of Gynecology and Obstetrics (FIGO) staging system, the disease was classified as stage I vaginal cancer. Postoperatively, the patient received radiotherapy (45 Gy) and high-dose-rate brachytherapy (14 Gy). Conclusions: The co-occurrence of vaginal cancer and utero-vaginal prolapse is exceedingly rare. Surgical intervention followed by radiotherapy is the most common treatment approach. Given the aggressive nature of the disease, comprehensive follow-up is essential. Further research is needed to determine whether long-term genital prolapse increases the risk of vaginal carcinoma.<\/jats:p>","DOI":"10.3390\/jcm14134622","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T13:06:17Z","timestamp":1751288777000},"page":"4622","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Primary Invasive Vaginal Carcinoma Associated with Complete Utero-Vaginal Prolapse: A Case Report and Literature Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5288-4616","authenticated-orcid":false,"given":"Maciej","family":"Korniluk","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Gynecological Oncology, St. John Paul 2nd Mazovia Regional Hospital in Siedlce, 08-110 Siedlce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weronika","family":"Niemyjska-Dmoch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Gynecological Oncology, St. John Paul 2nd Mazovia Regional Hospital in Siedlce, 08-110 Siedlce, Poland"},{"name":"Department of Obstetrics, Perinatology and Gynecology, Medical University of Warsaw, 02-091 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Gil-Soboci\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Radiotherapy, St. John Paul 2nd Mazovia Regional Hospital in Siedlce, 08-110 Siedlce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Kabat","sequence":"additional","affiliation":[{"name":"Department of Radiology, St. John Paul 2nd Mazovia Regional Hospital in Siedlce, 08-110 Siedlce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubomir","family":"Bodnar","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Radiotherapy, St. John Paul 2nd Mazovia Regional Hospital in Siedlce, 08-110 Siedlce, Poland"},{"name":"Faculty of Medical and Health Sciences, University of Siedlce, 08-110 Siedlce, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz","family":"Szewczyk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Gynecological Oncology, St. John Paul 2nd Mazovia Regional Hospital in Siedlce, 08-110 Siedlce, Poland"},{"name":"1st Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, 02-097 Warsaw, Poland"},{"name":"Department of Obstetrics and Gynecology, St. Sophia Hospital, 01-004 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/(SICI)1097-0142(19980901)83:5<1033::AID-CNCR30>3.0.CO;2-6","article-title":"The National Cancer Data Base report on cancer of the vagina","volume":"83","author":"Creasman","year":"1998","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. 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