{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:48:39Z","timestamp":1788922119325,"version":"build-2803163510"},"reference-count":87,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Osteoarthritis (OA) of the hip and knee is a common age-related degenerative disease characterized by joint pain, stiffness, and gait disturbances. This study investigated the influence of genetic polymorphisms in the OPRM1 (rs1799971) and COMT (rs4633, rs4680, rs4818, and rs6269) genes on the postoperative analgesic requirements in 195 diabetic and non-diabetic patients undergoing total hip or knee arthroplasty. Methods: The prospective study included all patients who were admitted between January and September 2020 and agreed to participate. Postoperative pain management was assessed based on acetaminophen, ketoprofen, and morphine consumption on the first and second postoperative day. Results: Multilevel regression analyses revealed a significant three-way interaction between diabetes, type of analgesic, and OPRM1rs1799971 polymorphism, indicating different analgesic dosing patterns in diabetic and non-diabetic patients. Two-way interactions between diabetes and COMT polymorphisms rs4633, rs4680, and rs6269 further influenced the analgesic requirements. No significant associations were found for COMT rs4818. The results show that diabetes and genetic factors significantly influence opioid requirements and pain perception. Conclusions: Given the complexity of pain management in diabetic patients, personalized analgesic strategies tailored to genetic and metabolic profiles could be useful in postoperative pain management and reducing opioid consumption.<\/jats:p>","DOI":"10.3390\/jcm14134634","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T13:06:17Z","timestamp":1751288777000},"page":"4634","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Do Diabetes and Genetic Polymorphisms in the COMT and OPRM1 Genes Modulate the Postoperative Opioid Demand and Pain Perception in Osteoarthritis Patients After Total Knee and Hip Arthroplasty?"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2822-858X","authenticated-orcid":false,"given":"Alina","family":"Jurewicz","sequence":"first","affiliation":[{"name":"Department of Specialistic Nursing, Pomeranian Medical University, \u017bo\u0142nierska 48, 71-210 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-1095","authenticated-orcid":false,"given":"Agata","family":"Gasiorowska","sequence":"additional","affiliation":[{"name":"Faculty of Psychology in Wroclaw, SWPS University, Ostrowskiego 30b, 54-238 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1747-5929","authenticated-orcid":false,"given":"Katarzyna","family":"Le\u017anicka","sequence":"additional","affiliation":[{"name":"Faculty of Physical Culture, Gdansk University of Physical Education and Sport, ul. K.G\u00f3rskiego 1, 80-336 Gdansk, Poland"},{"name":"Institute of Physical Culture Sciences, University of Szczecin, Al. Piast\u00f3w 40b, 70-453 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-2411","authenticated-orcid":false,"given":"Agnieszka","family":"Maciejewska-Skrendo","sequence":"additional","affiliation":[{"name":"Faculty of Physical Culture, Gdansk University of Physical Education and Sport, ul. K.G\u00f3rskiego 1, 80-336 Gdansk, Poland"},{"name":"Institute of Physical Culture Sciences, University of Szczecin, Al. Piast\u00f3w 40b, 70-453 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6326-2217","authenticated-orcid":false,"given":"Maciej","family":"Pawlak","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry, Poznan University of Physical Education, 61-871 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Machoy-Mokrzy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, al. Powstanc\u00f3w Wlkp.72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4773-0970","authenticated-orcid":false,"given":"Andrzej","family":"Bohatyrewicz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Traumatology and Musculoskeletal Oncology, Pomeranian Medical University, Unii Lubelskiej 1, 71-252 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-5077","authenticated-orcid":false,"given":"Maciej","family":"Tarnowski","sequence":"additional","affiliation":[{"name":"Institute of Physical Culture Sciences, University of Szczecin, Al. Piast\u00f3w 40b, 70-453 Szczecin, Poland"},{"name":"Department of Physiology in Health Sciences, Pomeranian Medical University, al. Powstanc\u00f3w Wlkp.72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: A Lancet Commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1056\/NEJMcp1903768","article-title":"Osteoarthritis of the Knee","volume":"384","author":"Sharma","year":"2021","journal-title":"N. Engl. J. 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