{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:37:07Z","timestamp":1779237427185,"version":"3.51.4"},"reference-count":41,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science (JSPS) KA KENHI","doi-asserted-by":"publisher","award":["22K08033"],"award-info":[{"award-number":["22K08033"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) causes progressive liver fibrosis. Although erythrocyte mean corpuscular volume (MCV) has been shown to have a positive correlation with all-cause mortality, the association between MCV and the development of MASLD has not been fully elucidated. Here, we examined the clinical significance of the association between MCV and MASLD. Methods: A cross-sectional study was carried out in 1009 Japanese individuals (including 186 individuals aged &lt; 60 years and 823 individuals aged \u2265 60 years) with metabolic disorders. The relationships between MCV and noninvasive clinical markers of liver fibrosis, including fibrosis-4 (FIB-4) index, aspartate aminotransferase-to-platelet ratio index (APRI), and non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS), were statistically evaluated. Results: Using multiple and logistic regression analyses in overall subjects, it was found that MCV was positively and independently associated with the values of FIB-4 index, APRI, NFS, and the prevalence of liver fibrosis defined by each index. However, the associations between the MCV value and MASLD indices were found to be positive in subjects aged \u2265 60 years but not in those aged &lt; 60 years. Conclusions: MCV might be a simple and useful biomarker for the development of MASLD in the elderly.<\/jats:p>","DOI":"10.3390\/jcm14134680","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T06:10:26Z","timestamp":1751436626000},"page":"4680","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mean Corpuscular Volume Is Correlated with Liver Fibrosis Defined by Noninvasive Blood Biochemical Indices in Individuals with Metabolic Disorders Aged 60 Years or Older"],"prefix":"10.3390","volume":"14","author":[{"given":"Yousuke","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Tokushima Prefectural Kaifu Hospital, 266 Mugi-cho, Tokushima 775-0006, Japan"},{"name":"Department of Hematology, Endocrinology and Metabolism, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2256-0776","authenticated-orcid":false,"given":"Yutaka","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Medical Science, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Kawata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokushima Prefectural Kaifu Hospital, 266 Mugi-cho, Tokushima 775-0006, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokushima Prefectural Kaifu Hospital, 266 Mugi-cho, Tokushima 775-0006, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minae","family":"Hosoki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokushima Prefectural Kaifu Hospital, 266 Mugi-cho, Tokushima 775-0006, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4418-3865","authenticated-orcid":false,"given":"Taiki","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Tokushima Prefectural Kaifu Hospital, 266 Mugi-cho, Tokushima 775-0006, Japan"},{"name":"Department of Hematology, Endocrinology and Metabolism, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohsuke","family":"Miyataka","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"},{"name":"Department of Diabetes and Metabolism, Tokushima Prefectural Central Hospital, 1-10-3 Kuramoto-cho, Tokushima 770-8539, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seijiro","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Shikoku Medical Center for Children and Adults Hospital, 2-1-1 Senyu-cho, Kagawa 765-8507, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyo","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yamagami","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2244-3403","authenticated-orcid":false,"given":"Toshiki","family":"Otoda","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Medical Science, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Yuasa","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Medical Science, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3997-7471","authenticated-orcid":false,"given":"Takeshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Miki","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine and Cell Therapy, Tokushima University Hospital, 2-50-1 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5465-2758","authenticated-orcid":false,"given":"Shingen","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Medical Science, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0780-0065","authenticated-orcid":false,"given":"Itsuro","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Bioregulatory Sciences, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4624-939X","authenticated-orcid":false,"given":"Munehide","family":"Matsuhisa","sequence":"additional","affiliation":[{"name":"Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8906-0920","authenticated-orcid":false,"given":"Ken-ichi","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Medical Science, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan"},{"name":"Department of Internal Medicine, Anan Medical Center, 6-1 Kawahara Takarada-cho, Anan, Tokushima 774-0045, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S2468-1253(24)00193-6","article-title":"Natural history and progression of metabolic dysfunction-associated steatotic liver disease","volume":"9","author":"Shang","year":"2024","journal-title":"Lancet Gastroenterol. 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