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This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0.78 (2.34) mm\/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm\/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm\/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies.<\/jats:p>","DOI":"10.3390\/jcm14134720","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T08:22:07Z","timestamp":1751530927000},"page":"4720","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-5553","authenticated-orcid":false,"given":"Olga","family":"Peypoch","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"},{"name":"Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, IR SANT PAU, 08041 Barcelona, Spain"},{"name":"Department de Cirurgia i Ci\u00e8ncies Morfol\u00f2giques, Universitat Autonoma de Barcelona (UAB), 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Calsina Juscafresa","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Hospital del Mar de Barcelona, 08003 Barcelona, Spain"},{"name":"Department of Medicine and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0525-6635","authenticated-orcid":false,"given":"Ant\u00f3n","family":"Vega-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, IR SANT PAU, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6218-5774","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Lobato-Delgado","sequence":"additional","affiliation":[{"name":"Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, IR SANT PAU, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7820-6509","authenticated-orcid":false,"given":"Joan","family":"Fit\u00e9","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"},{"name":"Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, IR SANT PAU, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Soto","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain"},{"name":"Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, IR SANT PAU, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Nieto","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Hospital del Mar de Barcelona, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1384-4590","authenticated-orcid":false,"given":"Mireia","family":"de la Rosa Estadella","sequence":"additional","affiliation":[{"name":"Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, IR SANT PAU, 08041 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ager","family":"Uribezubia","sequence":"additional","affiliation":[{"name":"Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, IR SANT PAU, 08041 Barcelona, 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Investigaci\u00f3n Sanitaria La Fe, 46026 Valencia, Spain"},{"name":"Servicio de Angiolog\u00eda y Cirug\u00eda Vascular Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Facultad de Medicina, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Clar\u00e0","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, Hospital del Mar de Barcelona, 08003 Barcelona, Spain"},{"name":"Department of Medicine and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERECV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0127-0064","authenticated-orcid":false,"given":"Jaume","family":"Dilm\u00e9","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-379X","authenticated-orcid":false,"given":"Maria","family":"Sabater-Lleal","sequence":"additional","affiliation":[{"name":"Unit of Genomics of Complex Disease, Institut de Recerca Sant Pau, IR SANT PAU, 08041 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), 28209 Madrid, Spain"},{"name":"Cardiology Unit, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine, 171 76 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1358\/dnp.2008.21.3.1203410","article-title":"Basic research studies to understand aneurysm disease","volume":"21","author":"Boddy","year":"2008","journal-title":"Drug News 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