{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T03:48:59Z","timestamp":1779162539973,"version":"3.51.4"},"reference-count":78,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Previous proteomic studies provided valuable information about cataracts, but unclarified issues, such as sex and ethnicity-associated differences, remain. This study aimed to provide additional data on cataract-related proteins regarding age, sex, and cataract type. Methods: Twenty-six female and seven male Turkish cataract patients were screened for visual acuity and dysfunctional lens index. A nano-LC-MS\/MS system and Progenesis QI software v3.0 were used for protein identification and quantification. The remaining data were evaluated with SPSS Version 29.0 software. Results: Proteins that showed age-associated changes were mainly involved in cytoskeletal organization. A glyoxalase enzyme, caveolin 1, and HS90B were lower, and RAB8B and ATP6V1B1 were higher in lenses in women. Proteins with lower levels in cataractous lenses than in transparent lenses included filensin and phakinin, concurrent with previous publications, and LCTL, GDI, HSPB1, and EIF4A2, not reported before. Corticonuclear cataracts constituted the only group showing depletions in putatively protective proteins, while the cortical type was the least influenced. ANXA1 and DNHD1 positively, and TCPD, SEC14L2, and PRPS1 proteins negatively correlated with visual acuity. Conclusions: This study revealed cataract-related proteins concurrent with earlier studies and new ones hitherto unreported. Despite the low number of patients investigated, the results merit further research, as these new proteins are highly likely to be involved in cataractogenesis.<\/jats:p>","DOI":"10.3390\/jcm14134737","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T05:54:52Z","timestamp":1751608492000},"page":"4737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lens Proteomics Provide Novel Clues for Cataractogenesis: Original Investigation and a Broad Literature Survey"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-9798","authenticated-orcid":false,"given":"Banu","family":"Cosar","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Ophthalmology, Acibadem Mehmet Ali Ayd\u0131nlar University, Istanbul 34398, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Sehvar","family":"Nefesoglu","sequence":"additional","affiliation":[{"name":"Avrupa Vocational School, Kocaeli Health and Technology University, Kocaeli 41001, T\u00fcrkiye"},{"name":"Ophthalmology Clinic, Atasehir Florence Nightingale Hospital, Istanbul 34750, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meric A.","family":"Altinoz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biochemistry, Acibadem Mehmet Ali Ayd\u0131nlar University, Istanbul 34638, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"Akgun","sequence":"additional","affiliation":[{"name":"Ac\u0131badem LabMed Clinical Laboratories, Istanbul 34752, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul","family":"Sahin","sequence":"additional","affiliation":[{"name":"Ac\u0131badem LabMed Clinical Laboratories, Istanbul 34752, T\u00fcrkiye"},{"name":"Department of Biochemistry, Bahcesir University, Istanbul 34349, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-7351","authenticated-orcid":false,"given":"Ahmet","family":"Baykal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biochemistry, Acibadem Mehmet Ali Ayd\u0131nlar University, Istanbul 34638, T\u00fcrkiye"},{"name":"Ac\u0131badem LabMed Clinical Laboratories, Istanbul 34752, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-7613","authenticated-orcid":false,"given":"Mustafa","family":"Serteser","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Biochemistry, Acibadem Mehmet Ali Ayd\u0131nlar University, Istanbul 34638, T\u00fcrkiye"},{"name":"Ac\u0131badem LabMed Clinical Laboratories, Istanbul 34752, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s41433-020-0806-3","article-title":"Global and regional prevalence of age-related cataract: A comprehensive systematic review and meta-analysis","volume":"34","author":"Hashemi","year":"2020","journal-title":"Eye"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/j.jcrs.0000000000001329","article-title":"Prevalence of cortical cataracts by sex, race, and ethnicity in a Colorado cohort","volume":"50","author":"Patnaik","year":"2024","journal-title":"J. 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