{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:06:25Z","timestamp":1782453985366,"version":"3.54.5"},"reference-count":22,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Primary focal hyperhidrosis, characterized by excessive sweating primarily affecting the hands and axillae, can significantly impact quality of life. Bilateral thoracic sympathectomy is the gold standard treatment, providing permanent resolution of palmar hyperhidrosis. Most studies evaluating outcomes and patient satisfaction after sympathectomy focus on short- to medium-term follow-up, typically up to 5 years. This study aimed to assess anxiety, satisfaction, and sweat redistribution 20 years after bilateral endoscopic thoracic sympathectomy. Methods: Between January 2002 and December 2003, 106 patients with primary hyperhidrosis underwent bilateral endoscopic thoracic sympathectomy targeting ganglia T2\u2013T3 at our center. The patients were contacted via telephone in 2023 and asked to complete the same survey they had filled out preoperatively and 12 months postoperatively. The survey evaluated sweat redistribution, anxiety, hyperhidrosis-related symptoms, and satisfaction. Anxiety, satisfaction, and perceived sweating were rated using a 5-point visual analog scale (VAS) ranging from 0 (unsatisfied\/no symptoms) to 4 (very satisfied\/severe symptoms). Results: Of the 106 eligible patients, 24 (22.6%) completed the survey. Most reported persistent anhidrosis (palmar or palmar\u2013axillary) 20 years post-surgery. The survey results remained consistent with those at the 1-year follow-up. Significant sweat redistribution to the abdomen and back was observed. Patient satisfaction remained high, with no significant differences between the 1-year and 20-year assessments. Anxiety significantly decreased compared to preoperative levels (p &lt; 0.001). Conclusions: Bilateral endoscopic thoracic sympathectomy is an effective long-term treatment for reducing excessive sweating. Patient satisfaction remains high over time, despite the persistence of compensatory sweating.<\/jats:p>","DOI":"10.3390\/jcm14144831","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:31:57Z","timestamp":1751959917000},"page":"4831","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["20-Year Efficacy of Endoscopic Thoracic Sympathectomy for Primary Hyperhidrosis: A Cohort Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-9917","authenticated-orcid":false,"given":"Anna","family":"Ure\u00f1a","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Clinic of Barcelona, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer-IDIBAPS, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Grando","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Clinic of Barcelona, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluisa","family":"Rodriguez-Gussinyer","sequence":"additional","affiliation":[{"name":"Facultat de Medicina, Universitat de Barcelona, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-2052","authenticated-orcid":false,"given":"Ivan","family":"Mac\u00eda","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitari de Bellvitge, Universitat de Barcelona, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5718-8900","authenticated-orcid":false,"given":"Francisco","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitari de Bellvitge, Universitat de Barcelona, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7159-1862","authenticated-orcid":false,"given":"Nestor Iv\u00e1n","family":"Quiroga","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Clinic of Barcelona, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8632-830X","authenticated-orcid":false,"given":"Camilo","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Universitari de Bellvitge, Universitat de Barcelona, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9258-0287","authenticated-orcid":false,"given":"Xavier","family":"Michavilla","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Clinic of Barcelona, Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5557-9812","authenticated-orcid":false,"given":"Ricard","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Hospital Clinic of Barcelona, Universitat de Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer-IDIBAPS, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0025-7753(03)73906-2","article-title":"Hiperhidrosis primaria: Estudio prospectivo de 338 pacientes","volume":"121","author":"Ramos","year":"2003","journal-title":"Med. 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