{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:29:38Z","timestamp":1760059778577,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mayo Clinic Department of Medicine, Division of General Internal Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Patients with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) may report abnormalities in voice and speech; however, no formal research has been conducted in this area. Methods: An online mixed-methods survey was completed by 685 people with ME\/CFS. A total of 302 respondents completed the qualitative component (44.09%). Questions assessed disease experience with ME\/CFS and post-exertional malaise without prompting on specific symptoms. Within the qualitative results, a search of the terms \u201cspeech, voice,\u201d \u201cwords,\u201d and \u201cspeak\u201d was conducted. Results: Excluding neurocognitive associations, colloquial phrases, and \u201cspeech therapy,\u201d there were 38 mentions of the terms in the context of voice or speech changes across 28 unique qualitative survey responses (9.27%). Conclusions: A notable portion of respondents reported voice or speech changes when responding to open-ended qualitative questions about their disease experience. More research is needed regarding the implications of voice and speech anomalies in ME\/CFS pathology and disease monitoring.<\/jats:p>","DOI":"10.3390\/jcm14144847","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T11:58:07Z","timestamp":1751975887000},"page":"4847","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Signal for Voice and Speech Abnormalities in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8337-6219","authenticated-orcid":false,"given":"Stephanie L.","family":"Grach","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-3585","authenticated-orcid":false,"given":"Jaime","family":"Seltzer","sequence":"additional","affiliation":[{"name":"The Myalgic Encephalomyelitis Action Network, Santa Monica, CA 90401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-2077","authenticated-orcid":false,"given":"Diana M.","family":"Orbelo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jvoice.2019.07.022","article-title":"Associations Between Autonomic Nervous System Function, Voice, and Dysphonia: A Systematic Review","volume":"35","author":"Cardoso","year":"2021","journal-title":"J. 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