{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:35:47Z","timestamp":1788914147452,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Mitral regurgitation (MR) is a common valvular heart disease associated with significant morbidity and mortality. For patients at high or prohibitive surgical risk, mitral transcatheter edge-to-edge repair (M-TEER) offers a less invasive alternative to surgery. This review outlines key aspects of patient selection and procedural planning for M-TEER, with a focus on clinical and echocardiographic criteria essential for success. Comprehensive imaging\u2014especially 2D and 3D transesophageal echocardiography\u2014is critical to assess leaflet anatomy, coaptation geometry, and mitral valve area. Selection criteria differ between primary and secondary MR and are guided by trials such as COAPT and MITRA-FR. Optimal outcomes rely on careful screening, anatomical suitability, and multidisciplinary evaluation. With growing experience and advancing technology, M-TEER has become a transformative option for treating severe MR in non-surgical candidates.<\/jats:p>","DOI":"10.3390\/jcm14144902","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T11:26:37Z","timestamp":1752233197000},"page":"4902","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Screening and Procedural Guidance for Mitral Transcatheter Edge-to-Edge Repair (M-TEER)"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-0287","authenticated-orcid":false,"given":"Andromahi","family":"Zygouri","sequence":"first","affiliation":[{"name":"Cardiology Department, Universit\u00e9 of Rennes, CHU Rennes, Inserm, LTSI\u2013UMR 1099, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5478-4610","authenticated-orcid":false,"given":"Prayuth","family":"Rasmeehirun","sequence":"additional","affiliation":[{"name":"Cardiology Department, Universit\u00e9 of Rennes, CHU Rennes, Inserm, LTSI\u2013UMR 1099, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6379-0156","authenticated-orcid":false,"given":"Guillaume","family":"L\u2019Official","sequence":"additional","affiliation":[{"name":"Cardiology Department, Universit\u00e9 of Rennes, CHU Rennes, Inserm, LTSI\u2013UMR 1099, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7356-2379","authenticated-orcid":false,"given":"Konstantinos","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory, European Interbalkan Medical Center, 57001 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-7886","authenticated-orcid":false,"given":"Ignatios","family":"Ikonomidis","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory, 2nd Cardiology Department, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-3389","authenticated-orcid":false,"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[{"name":"Cardiology Department, Universit\u00e9 of Rennes, CHU Rennes, Inserm, LTSI\u2013UMR 1099, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: A population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0195-668X(03)00201-X","article-title":"A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease","volume":"24","author":"Iung","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.jcmg.2022.08.016","article-title":"Atrial Functional Mitral Regurgitation","volume":"15","author":"Flachskampf","year":"2022","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Iliakis, P., Dimitriadis, K., Pyrpyris, N., Beneki, E., Theofilis, P., Tsioufis, P., Kamperidis, V., Aznaouridis, K., Aggeli, K., and Tsioufis, K. (2024). Atrial Functional Mitral Regurgitation: From Diagnosis to Current Interventional Therapies. J. Clin. Med., 13.","DOI":"10.3390\/jcm13175035"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e004984","DOI":"10.1136\/bmjopen-2014-004984","article-title":"Prognostic impact of moderate or severe mitral regurgitation (MR) irrespective of concomitant comorbidities: A retrospective matched cohort study","volume":"4","author":"Prakash","year":"2014","journal-title":"BMJ Open"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(09)60692-9","article-title":"Mitral regurgitation","volume":"373","author":"Akins","year":"2009","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1001\/jamacardio.2017.2976","article-title":"Survival and Cardiovascular Outcomes of Patients with Secondary Mitral Regurgitation: A Systematic Review and Meta-analysis","volume":"2","author":"Sannino","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation: A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1366444","DOI":"10.3389\/fcvm.2024.1366444","article-title":"The added value of three-dimensional transthoracic echocardiography in mitral annular disjunction: A case report","volume":"11","author":"Papadopoulos","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_10","first-page":"376","article-title":"How to measure severity of mitral regurgitation: Valvular heart disease","volume":"94","author":"Grayburn","year":"2008","journal-title":"Postgrad. Med. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1093\/ehjci\/jeab253","article-title":"Multi-modality imaging assessment of native valvular regurgitation: An EACVI and ESC council of valvular heart disease position paper","volume":"23","author":"Lancellotti","year":"2022","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"43","author":"Vahanian","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA Guideline for the Management of Patients with Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMoa041451","article-title":"Quantitative determinants of the outcome of asymptomatic mitral regurgitation","volume":"352","author":"Avierinos","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1016\/j.jacc.2019.02.075","article-title":"A Unifying Concept for the Quantitative Assessment of Secondary Mitral Regurgitation","volume":"73","author":"Bartko","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/CIRCULATIONAHA.116.025260","article-title":"Exercise Dynamics in Secondary Mitral Regurgitation: Pathophysiology and Therapeutic Implications","volume":"135","author":"Bertrand","year":"2017","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"883450","DOI":"10.3389\/fcvm.2022.883450","article-title":"Dynamic Secondary Mitral Regurgitation: Current Evidence and Challenges for the Future","volume":"9","author":"Onishi","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"ezaf029","DOI":"10.1093\/ejcts\/ezaf029","article-title":"Outcomes of patients with mitral annular disjunction undergoing mitral valve repair\u2020","volume":"67","author":"Muneretto","year":"2025","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJMoa1512913","article-title":"Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation","volume":"374","author":"Goldstein","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1056\/NEJMoa2408739","article-title":"Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation","volume":"391","author":"Baldus","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jcin.2022.06.005","article-title":"Transcatheter Edge-to-Edge Repair for Atrial Secondary Mitral Regurgitation","volume":"15","author":"Tanaka","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"von Stein, P., Stolz, L., Haurand Jean, M., Gr\u00f6ger, M., Rudolph, F., Mustafa, D., Jobst, J., Mues Christoph, A., Mahabadi Amir, A., and Hoerbrand Isabel, A. (2025). Transcatheter Edge-to-Edge Repair for Atrial and Ventricular Secondary Mitral Regurgitation. JACC Cardiovasc. Interv., in press.","DOI":"10.1016\/j.jcin.2025.05.031"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter Mitral-Valve Repair in Patients with Heart Failure","volume":"379","author":"Stone","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/j.jacc.2024.08.027","article-title":"Hospitalization of Symptomatic Patients with Heart Failure and Moderate to Severe Functional Mitral Regurgitation Treated with MitraClip: Insights from RESHAPE-HF2","volume":"84","author":"Ponikowski","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation","volume":"379","author":"Obadia","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"jeae333.146","DOI":"10.1093\/ehjci\/jeae333.146","article-title":"Reverse remodeling according to the aetiology after mitral TEER","volume":"26","author":"Marut","year":"2025","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous repair or surgery for mitral regurgitation","volume":"364","author":"Feldman","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcmg.2018.11.006","article-title":"Proportionate and Disproportionate Functional Mitral Regurgitation: A New Conceptual Framework That Reconciles the Results of the MITRA-FR and COAPT Trials","volume":"12","author":"Grayburn","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jcmg.2020.06.032","article-title":"Regurgitant Volume\/Left Ventricular End-Diastolic Volume Ratio: Prognostic Value in Patients with Secondary Mitral Regurgitation","volume":"14","author":"Namazi","year":"2021","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"742224","DOI":"10.3389\/fcvm.2021.742224","article-title":"Disproportionate Mitral Regurgitation Determines Survival in Acute Heart Failure","volume":"8","author":"Berrill","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1056\/NEJMoa2314328","article-title":"Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation","volume":"391","author":"Anker","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jchf.2024.08.001","article-title":"Evaluating Mitral TEER in the Management of Moderate Secondary Mitral Regurgitation Among Heart Failure Patients","volume":"13","author":"Asgar","year":"2025","journal-title":"JACC Heart Fail."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/ehjci\/jet141","article-title":"Integrated reverse left and right ventricular remodelling after MitraClip implantation in functional mitral regurgitation: An echocardiographic study","volume":"15","author":"Giannini","year":"2014","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.echo.2012.07.015","article-title":"Left Cardiac Chambers Reverse Remodeling after Percutaneous Mitral Valve Repair with the MitraClip System","volume":"25","author":"Scandura","year":"2012","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/ehf2.12750","article-title":"MitraClip and left ventricular reverse remodelling: A strain imaging study","volume":"7","author":"Papadopoulos","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2459\/JCM.0000000000000526","article-title":"Global longitudinal strain predicts outcome after MitraClip implantation for secondary mitral regurgitation","volume":"18","author":"Citro","year":"2017","journal-title":"J. Cardiovasc. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.healun.2020.09.005","article-title":"MitraClip in secondary mitral regurgitation as a bridge to heart transplantation: 1-year outcomes from the International MitraBridge Registry","volume":"39","author":"Godino","year":"2020","journal-title":"J. Heart Lung Transpl."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcin.2020.08.037","article-title":"Transcatheter Mitral Valve Repair in Cardiogenic Shock and Mitral Regurgitation: A Patient-Level, Multicenter Analysis","volume":"14","author":"Jung","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4244\/EIJ-D-22-00725","article-title":"Mitral valve transcatheter edge-to-edge repair","volume":"18","author":"Hausleiter","year":"2023","journal-title":"EuroIntervention"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/ehjci\/jeaa062","article-title":"Conceiving MitraClip as a tool: Percutaneous edge-to-edge repair in complex mitral valve anatomies","volume":"21","author":"Gavazzoni","year":"2020","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00392-013-0614-x","article-title":"Percutaneous interventional mitral regurgitation treatment using the Mitra-Clip system","volume":"103","author":"Boekstegers","year":"2014","journal-title":"Clin. Res. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/ejhf.520","article-title":"Mitraclip therapy in patients with functional mitral regurgitation and missing leaflet coaptation: Is it still an exclusion criterion?","volume":"18","author":"Adamo","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/ehjci\/jes310","article-title":"The prevalence and impact of deep clefts in the mitral leaflets in mitral valve prolapse","volume":"14","author":"Ring","year":"2013","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.amjcard.2010.12.048","article-title":"Real-time three-dimensional transesophageal echocardiography for assessment of mitral valve functional anatomy in patients with prolapse-related regurgitation","volume":"107","author":"Arendar","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.jcin.2019.03.023","article-title":"Edge-to-Edge Mitral Valve Repair with Extended Clip Arms: Early Experience from a Multicenter Observational Study","volume":"12","author":"Praz","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"589","DOI":"10.4103\/0971-9784.191548","article-title":"Different transseptal puncture for different procedures: Optimization of left atrial catheterization guided by transesophageal echocardiography","volume":"19","author":"Radinovic","year":"2016","journal-title":"Ann. Card. Anaesth."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"100340","DOI":"10.1016\/j.shj.2024.100340","article-title":"Targeting the Future: Three-Dimensional Imaging for Precise Guidance of the Transseptal Puncture","volume":"9","author":"Harb","year":"2025","journal-title":"Struct. Heart"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jacc.2015.05.049","article-title":"Clinical Trial Design Principles and Endpoint Definitions for Transcatheter Mitral Valve Repair and Replacement: Part 2: Endpoint Definitions: A Consensus Document from the Mitral Valve Academic Research Consortium","volume":"66","author":"Stone","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.echo.2024.01.016","article-title":"Pulmonary Vein Flow Morphology After Transcatheter Mitral Valve Edge-to-Edge Repair as Predictor of Survival","volume":"37","author":"Ali","year":"2024","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.echo.2022.08.010","article-title":"Significance of Spontaneous Echocardiographic Contrast in Transcatheter Edge-to-Edge Repair for Mitral Regurgitation","volume":"36","author":"Sato","year":"2023","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jacc.2013.02.094","article-title":"Percutaneous mitral valve interventions in the real world: Early and 1-year results from the ACCESS-EU, a prospective, multicenter, nonrandomized post-approval study of the MitraClip therapy in Europe","volume":"62","author":"Maisano","year":"2013","journal-title":"J. Am. Coll. 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