{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:46:06Z","timestamp":1790959566344,"version":"4.1.0"},"reference-count":21,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The optimal anticoagulation strategy for obese patients with superficial vein thrombosis (SVT) remains unclear. This study evaluates the impact of obesity on anticoagulation patterns and clinical outcomes in patients with lower limb SVT. Methods: We conducted a prospective observational study including consecutive patients with SVT in a tertiary hospital from 2014 to 2024. Patients with SVT \u2265 5 cm in length and \u22653 cm from the saphenofemoral junction were included. Obese (BMI \u2265 30) and non-obese (BMI &lt; 30) patients were compared. Patients were followed for one year. Outcomes were assessed at 90 and 365 days. The primary outcomes were venous thromboembolism (VTE) recurrence (SVT, deep vein thrombosis [DVT], or pulmonary embolism [PE]). The secondary outcomes were major bleeding and all-cause mortality. Results: Of 136 patients, 58 (42.6%) were obese. Both groups had similar baseline characteristics, except for younger age and higher smoking prevalence in obese patients. Most patients received anticoagulation (91.9%), primarily a prophylactic dose of low molecular weight heparin or a prophylactic dose of fondaparinux. No significant differences were found in VTE recurrence at 90 or 365 days (p = 0.505), and no major bleeding events occurred. Female sex was associated with a higher risk of VTE recurrence (OR 4.33, 95% CI 1.17\u201315.98, p = 0.028), but obesity did not influence outcomes. Conclusions: Obesity was not associated with increased VTE recurrence in patients with lower limb SVT. No major bleeding events were observed. These findings suggest that standard anticoagulation regimens may be appropriate for obese patients with SVT, but further studies are needed to confirm these results.<\/jats:p>","DOI":"10.3390\/jcm14145024","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T10:46:05Z","timestamp":1752662765000},"page":"5024","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Superficial Vein Thrombosis in Obese Patients"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6094-1633","authenticated-orcid":false,"given":"Luc\u00eda","family":"Ordieres-Ortega","sequence":"first","affiliation":[{"name":"Venous Thromboembolism Unit, Internal Medicine Department, General University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5492-7061","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Alonso-Beato","sequence":"additional","affiliation":[{"name":"Venous Thromboembolism Unit, Internal Medicine Department, General University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8234-1615","authenticated-orcid":false,"given":"Tatiana","family":"Pire-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Venous Thromboembolism Unit, Internal Medicine Department, General University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-728X","authenticated-orcid":false,"given":"Sergio","family":"Morag\u00f3n-Ledesma","sequence":"additional","affiliation":[{"name":"Venous Thromboembolism Unit, Internal Medicine Department, General University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-304X","authenticated-orcid":false,"given":"Marina","family":"L\u00f3pez-Rubio","sequence":"additional","affiliation":[{"name":"Venous Thromboembolism Unit, Internal Medicine Department, General University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4445-7697","authenticated-orcid":false,"given":"Marta-Olimpia","family":"Lago-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Venous Thromboembolism Unit, Internal Medicine Department, General University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Antonio","family":"Alvarez-Sala Walther","sequence":"additional","affiliation":[{"name":"Venous Thromboembolism Unit, Internal Medicine Department, General University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1321-6866","authenticated-orcid":false,"given":"Francisco","family":"Galeano-Valle","sequence":"additional","affiliation":[{"name":"Venous Thromboembolism Unit, Internal Medicine Department, General University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-4711","authenticated-orcid":false,"given":"Pablo","family":"Demelo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Venous Thromboembolism Unit, Internal Medicine Department, General University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"ref_1","first-page":"e20180105","article-title":"Guidelines for superficial venous thrombosis","volume":"18","author":"Guillaumon","year":"2019","journal-title":"J. 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Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/14\/5024\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:10:27Z","timestamp":1760033427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/14\/5024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,16]]},"references-count":21,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["jcm14145024"],"URL":"https:\/\/doi.org\/10.3390\/jcm14145024","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,16]]}}}