{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:20:41Z","timestamp":1792516841632,"version":"4.5.0"},"reference-count":64,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Non-invasive ventilation (NIV) is a cornerstone in the management of acute and chronic respiratory failure, offering critical support without the risks of intubation. However, successful weaning from NIV remains a complex, high-stakes process. Poorly timed or improperly executed weaning significantly increases morbidity and mortality, yet current clinical practice often relies on subjective judgment rather than evidence-based protocols. This manuscript reviews the current landscape of NIV weaning, emphasizing structured approaches, objective monitoring, and predictors of weaning success or failure. It examines guideline-based indications, monitoring strategies, and various weaning techniques\u2014gradual and abrupt\u2014with evidence of their efficacy across different patient populations. Predictive tools such as the Rapid Shallow Breathing Index, Lung Ultrasound Score, Diaphragm Thickening Fraction, ROX index, and HACOR score are analyzed for their diagnostic value. Additionally, this review underscores the importance of care setting\u2014ICU, step-down unit, or general ward\u2014and how it influences outcomes. Finally, it highlights critical gaps in research, especially around weaning in non-ICU environments. By consolidating current evidence and identifying predictors and pitfalls, this article aims to support clinicians in making safe, timely, and patient-specific NIV weaning decisions. In the current literature, there are gaps regarding patient selection and lack of universal protocolization for initiation and de-escalation of NIV as the data has been scattered. This review aims to consolidate the relevant information to be utilized by clinicians throughout multiple levels of care in all hospital systems.<\/jats:p>","DOI":"10.3390\/jcm14145033","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T12:55:00Z","timestamp":1752670500000},"page":"5033","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Non-Invasive Ventilation: When, Where, How to Start, and How to Stop"],"prefix":"10.3390","volume":"14","author":[{"given":"Mary","family":"Zimnoch","sequence":"first","affiliation":[{"name":"Department of Pulmonary & Critical Care Medicine, Northwell Lenox Hill Hospital, New York, NY 10075, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Eldeiry","sequence":"additional","affiliation":[{"name":"Department of Pulmonary & Critical Care Medicine, Northwell Lenox Hill Hospital, New York, NY 10075, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwabunmi","family":"Aruleba","sequence":"additional","affiliation":[{"name":"Department of Pulmonary & Critical Care Medicine, Northwell Lenox Hill Hospital, New York, NY 10075, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Pulmonary & Critical Care Medicine, Northwell Lenox Hill Hospital, New York, NY 10075, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Avaricio","sequence":"additional","affiliation":[{"name":"Department of Pulmonary & Critical Care Medicine, Northwell Northern Westchester Hospital, New York, NY 10549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Pulmonary & Critical Care Medicine, Northwell Northern Westchester Hospital, New York, NY 10549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Mina","sequence":"additional","affiliation":[{"name":"Department of Pulmonary & Critical Care Medicine, Northwell Northern Westchester Hospital, New York, NY 10549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-2050","authenticated-orcid":false,"given":"Antonio","family":"Esquinas","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Hospital Meseguer, NIV-ICM, Instituto Murciano de Investigaci\u00f3n Biosanitaria, 30008 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"ref_1","first-page":"PA3061","article-title":"Non-invasive ventilation simulation session outcomes in healthcare professionals","volume":"48","author":"Stewart","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.hrtlng.2016.04.006","article-title":"The effect of reintubation on ventilator-associated pneumonia and mortality among mechanically ventilated patients with intubation: A systematic review and meta-analysis","volume":"45","author":"Gao","year":"2016","journal-title":"Heart Lung"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chihara, Y., Egawa, H., Oga, T., Tsuboi, T., Handa, T., Yagi, S., Iida, T., Yoshizawa, A., Yamamoto, K., and Mishima, M. (2013). Predictive Factors for Reintubation following Noninvasive Ventilation in Patients with Respiratory Complications after Living Donor Liver Transplantation. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081417"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1056\/NEJMoa032736","article-title":"Noninvasive Positive-Pressure Ventilation for Respiratory Failure after Extubation","volume":"350","author":"Esteban","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1161\/CIR.0000000000001163","article-title":"Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement from the American Heart Association and Neurocritical Care Society","volume":"149","author":"Hirsch","year":"2024","journal-title":"Circulation"},{"key":"ref_6","first-page":"3","article-title":"Parameters predicting non-invasive ventilation failure in COVID-19 patients","volume":"11","author":"Nerpii","year":"2024","journal-title":"Mold. J. Health Sci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Karagiannidis, C., Hentschker, C., Westhoff, M., Weber-Carstens, S., Janssens, U., Kluge, S., Pfeifer, M., Spies, C., Welte, T., and Rossaint, R. (2022). Observational study of changes in utilization and outcomes in mechanical ventilation in COVID-19. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0262315"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.chest.2016.10.036","article-title":"Liberation from mechanical ventilation in critically ill adults: An official American College of Chest Physicians\/American Thoracic Society clinical practice guideline: Inspiratory pressure augmentation during spontaneous breathing trials, protocols minimizing sedation, and noninvasive ventilation immediately after extubation","volume":"151","author":"Ouellette","year":"2017","journal-title":"Chest"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jiph.2022.02.004","article-title":"Noninvasive ventilation improves the outcome in patients with pneumonia-associated respiratory failure: Systematic review and meta-analysis","volume":"15","author":"Ruzsics","year":"2022","journal-title":"J. Infect. Public Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00134-015-4087-4","article-title":"Changing use of noninvasive ventilation in critically ill patients: Trends over 15 years in francophone countries","volume":"42","author":"Demoule","year":"2016","journal-title":"Intensive Care Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/jamainternmed.2020.5640","article-title":"Trends in Noninvasive and Invasive Mechanical Ventilation Among Medicare Beneficiaries at the End of Life","volume":"181","author":"Sullivan","year":"2021","journal-title":"JAMA Intern. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/crj.13678","article-title":"Home noninvasive ventilation use in patients hospitalized with COPD","volume":"17","author":"Fortis","year":"2023","journal-title":"Clin. Respir. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0140-6736(09)60496-7","article-title":"Non-invasive ventilation in acute respiratory failure","volume":"374","author":"Nava","year":"2009","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2400396","DOI":"10.1183\/13993003.00396-2024","article-title":"Clinical review of non-invasive ventilation","volume":"64","author":"Criner","year":"2024","journal-title":"Eur. Respir. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1602426","DOI":"10.1183\/13993003.02426-2016","article-title":"Official ERS\/ATS clinical practice guidelines: Noninvasive ventilation for acute respiratory failure","volume":"50","author":"Rochwerg","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/jama.2015.12402","article-title":"Effect of noninvasive ventilation vs oxygen therapy on mortality among immunocompromised patients with acute respiratory failure: A randomized clinical trial","volume":"314","author":"Lemiale","year":"2015","journal-title":"JAMA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S2213-2600(16)30093-5","article-title":"Effect of non-invasive oxygenation strategies in immunocompromised patients with severe acute respiratory failure: A post-hoc analysis of a randomized trial","volume":"4","author":"Frat","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/ALN.0b013e3181c5e5f2","article-title":"Postoperative noninvasive ventilation","volume":"112","author":"Jaber","year":"2010","journal-title":"Anesthesiology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1164\/ajrccm.164.7.2101089","article-title":"Noninvasive ventilation reduces mortality in acute respiratory failure following lung resection","volume":"164","author":"Auriany","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jama.2016.2706","article-title":"Effect of noninvasive ventilation on tracheal reintubation among patients with hypoxemic respiratory failure following abdominal surgery: A randomized clinical trial","volume":"315","author":"Jaber","year":"2016","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1378\/chest.97.4.943","article-title":"Treatment of multiple rib fractures randomized controlled trial comparing ventilatory with nonventilatory management","volume":"97","author":"Bolliger","year":"1990","journal-title":"Chest"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/emj.2004.019786","article-title":"A comparative study of continuous positive airway pressure (CPAP) and intermittent positive pressure ventilation (IPPV) in patients with flail chest","volume":"22","author":"Gunduz","year":"2005","journal-title":"Emerg. Med. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1164\/rccm.200505-718OC","article-title":"Early noninvasive ventilation averts extubation failure in patients at risk: A randomized trial","volume":"173","author":"Ferrer","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1097\/01.CCM.0000186416.44752.72","article-title":"Noninvasive ventilation to prevent respiratory failure after extubation in high-risk patients","volume":"33","author":"Nava","year":"2005","journal-title":"Crit. Care Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"c7237","DOI":"10.1136\/bmj.c7237","article-title":"Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis","volume":"342","author":"Blackwood","year":"2011","journal-title":"BMJ"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1183\/09031936.00010206","article-title":"Weaning from mechanical ventilation","volume":"29","author":"Boles","year":"2007","journal-title":"Eur. Respir. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/eurheartj\/ehx580","article-title":"Indications and practical approach to non-invasive ventilation in acute heart failure","volume":"39","author":"Masip","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/bja\/aet070","article-title":"Complications of non-invasive ventilation techniques: A comprehensive qualitative review of randomized trials","volume":"110","author":"Carron","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pulmoe.2022.07.010","article-title":"How do I wean a patient with acute hypercapnic respiratory failure from noninvasive ventilation?","volume":"29","author":"Ugurlua","year":"2023","journal-title":"Pulmonology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1164\/rccm.201610-2076ST","article-title":"Official executive summary of an American Thoracic Society\/American College of Chest Physicians clinical practice guideline: Liberation from mechanical ventilation in critically ill adults","volume":"195","author":"Schmidt","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Yi, L.J., Tian, X., Chen, M., Ding, Q., Chen, Z., Wu, Y., Liu, D., Zhang, S., Xu, X., and Huang, W. (2021). Comparative efficacy and safety of four different spontaneous breathing trials for weaning from mechanical ventilation: A systematic review and network meta-analysis. Front. Med., 8.","DOI":"10.3389\/fmed.2021.731196"},{"key":"ref_32","first-page":"3478968","article-title":"Noninvasive ventilation weaning in acute hypercapnic respiratory failure due to COPD exacerbation: A real-life observational study","volume":"2019","author":"Faverio","year":"2019","journal-title":"Can. Respir. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1097\/TA.0b013e318249a0d5","article-title":"Protocol-directed versus physician-directed weaning from noninvasive ventilation: The impact on chronic obstructive pulmonary disease patients","volume":"72","author":"Duan","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1002\/ppul.24890","article-title":"Weaning from Noninvasive Ventilation and High Flow Nasal Cannula in Bronchiolitis: A Survey of Practice","volume":"55","author":"Suzanne","year":"2020","journal-title":"Pediatr. Pulmonol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJMra2204556","article-title":"Noninvasive Respiratory Support for Adults with Acute Respiratory Failure","volume":"387","author":"Munshi","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/resp.12080","article-title":"A pilot randomized study comparing two methods of non-invasive ventilation withdrawal after acute respiratory failure in chronic obstructive pulmonary disease","volume":"18","author":"Lun","year":"2013","journal-title":"Respirology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1601448","DOI":"10.1183\/13993003.01448-2016","article-title":"Discontinuing noninvasive ventilation in severe chronic obstructive pulmonary disease exacerbations: A randomized controlled trial","volume":"50","author":"Sellares","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"170101","DOI":"10.1183\/16000617.0101-2017","article-title":"How Should We Monitor Patients with Acute Respiratory Failure Treated with Noninvasive Ventilation?","volume":"27","author":"Ergan","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bja.2024.11.023","article-title":"Early noninvasive ventilation in general wards for acute respiratory failure: An international, multicenter, open-label, randomized trial","volume":"134","author":"Monti","year":"2025","journal-title":"Br. J. Anaesth."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00408-021-00469-z","article-title":"Predictors of Successful Weaning from Noninvasive Ventilation in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Single-Center Retrospective Cohort Study","volume":"199","author":"Yu","year":"2021","journal-title":"Lung"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kheir, M., Dong, V., Roselli, V., and Mina, B. (2023). The role of ultrasound in predicting non-invasive ventilation outcomes: A systematic review. Front. Med., 31.","DOI":"10.3389\/fmed.2023.1233518"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Li, S., Chen, Z., and Yan, W. (2021). Application of bedside ultrasound in predicting the outcome of weaning from mechanical ventilation in elderly patients. BMC Pulm. Med., 21.","DOI":"10.1186\/s12890-021-01605-4"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.4187\/respcare.11544","article-title":"Using the ROX Index to Predict Treatment Outcome for High-Flow Nasal Cannula and\/or Noninvasive Ventilation in Patients with COPD Exacerbations","volume":"69","author":"Schaeffer","year":"2024","journal-title":"Respir. Care"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jcrc.2020.08.008","article-title":"Validity of a clinical scale in predicting the failure of non-invasive ventilation in hypoxemic patients","volume":"60","author":"Carrillo","year":"2020","journal-title":"J. Crit. Care"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13613-019-0585-9","article-title":"Early prediction of noninvasive ventilation failure in COPD patients: Derivation, internal validation, and external validation of a simple risk score","volume":"9","author":"Duan","year":"2019","journal-title":"Ann. Intensive Care"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"900","DOI":"10.5005\/jp-journals-10071-24280","article-title":"Utility of the One-time HACOR Score as a Predictor of Weaning Failure from Mechanical Ventilation: A Prospective Observational Study","volume":"26","author":"Chaudhuri","year":"2022","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1513\/AnnalsATS.202109-1059ED","article-title":"Defining Failure of Noninvasive Ventilation for Acute Respiratory Distress Syndrome: Have We Succeeded?","volume":"19","author":"Ferreyro","year":"2022","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"180029","DOI":"10.1183\/16000617.0029-2018","article-title":"Noninvasive ventilation in acute respiratory failure: Which recipe for success","volume":"27","author":"Scala","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nishikimi, M., Nishida, K., Shindo, Y., Taito, S., Kashiwagi, K., Otani, T., Hagiwara, E., Naito, H., Takeda, R., and Nishimura, M. (2021). Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0251030"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Corr\u00eaa, T.D., Sanches, P.R., de Morais, L.C., Silva, E., Vieira, S.R., Ornellas, D.S., Silva, U.V., Figueiredo, R.C., Moreira, L.F., and Amaral, J.B. (2015). Performance of noninvasive ventilation in acute respiratory failure in critically ill patients: A prospective, observational, cohort study. BMC Pulm. Med., 15.","DOI":"10.1186\/s12890-015-0139-3"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1007\/s00134-001-1114-4","article-title":"Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: A multi-center study","volume":"27","author":"Antonelli","year":"2001","journal-title":"Intensive Care Med."},{"key":"ref_52","first-page":"9914081","article-title":"Noninvasive Ventilation in Treatment of Respiratory Failure-Related COVID-19 Infection: Review of Literature","volume":"2022","author":"Mina","year":"2022","journal-title":"Can. Respir. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jcrc.2014.09.021","article-title":"The role of noninvasive positive pressure ventilation in community-acquired pneumonia","volume":"30","author":"Murad","year":"2015","journal-title":"J. Crit. Care"},{"key":"ref_54","first-page":"e9","article-title":"Predictors of failure of noninvasive ventilation in patients with severe community-acquired pneumonia","volume":"540","author":"Carron","year":"2010","journal-title":"J. Crit. Care"},{"key":"ref_55","first-page":"e79","article-title":"Clinical Prediction Score for Successful Weaning from Noninvasive Positive Pressure Ventilation (NIPPV) in Emergency Department; a Retrospective Cohort Study","volume":"10","author":"Triganjananun","year":"2022","journal-title":"Arch. Acad. Emerg. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1097\/00003246-199608000-00010","article-title":"Critical illness polyneuropathy: Clinical findings and outcomes of a frequent cause of neuromuscular weaning failure","volume":"24","author":"Hund","year":"1996","journal-title":"Crit. Care Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.chest.2023.03.011","article-title":"Respiratory Management of Patients with Neuromuscular Weakness: An American College of Chest Physicians Clinical Practice Guideline and Expert Panel Report","volume":"164","author":"Khan","year":"2023","journal-title":"Chest"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"E112","DOI":"10.1503\/cmaj.130974","article-title":"Noninvasive ventilation as a weaning strategy for mechanical ventilation in adults with respiratory failure: A Cochrane systematic review","volume":"186","author":"Burns","year":"2014","journal-title":"CMAJ"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1136\/thoraxjnl-2021-216993","article-title":"Non-invasive ventilation versus invasive weaning in critically ill adults: A systematic review and meta-analysis","volume":"77","author":"Burns","year":"2022","journal-title":"Thorax"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"813","DOI":"10.21037\/jtd.2016.03.21","article-title":"Noninvasive and invasive positive pressure ventilation for acute respiratory failure in critically ill patients: A comparative cohort study","volume":"8","author":"Meeder","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Vignon, P. (2023). Cardiopulmonary interactions during ventilator weaning. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1275100"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/CCM.0000000000005865","article-title":"Predictors of noninvasive ventilation failure in the post-extubation period: A systematic review and meta-analysis","volume":"51","author":"Hryciw","year":"2023","journal-title":"Crit. Care Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.4187\/respcare.07661","article-title":"Incidence, predictors, and outcomes of failure of noninvasive ventilation in acute heart failure hospitalization","volume":"65","author":"Metkus","year":"2020","journal-title":"Respir. Care"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jhin.2015.06.016","article-title":"Nosocomial pneumonia in non-invasive ventilation patients: Incidence characteristics outcomes","volume":"91","author":"Zhang","year":"2015","journal-title":"J. Hosp. 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