{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:39:17Z","timestamp":1787240357289,"version":"build-2736575974"},"reference-count":47,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The hemostatic system in the newborn is a complex entity, characterized by dynamism in its development; therefore, the correct measurement of its potential is challenging. In this narrative review, we analyzed the current knowledge of the \u201cdevelopmental hemostasis\u201d of the newborn; we also studied the performance of routine coagulation tests in its evaluation, with considerations about the establishment of neonatal age-specific normal ranges and about the role of preanalytical variables, in particular, hematocrit (which could represent an important cause of error); we also focused on the increasing importance of viscoelastic coagulation tests, which are becoming increasingly widespread (especially in some settings such as intensive care unit) and are able to quickly provide information about the hemostatic function of the newborn, even if they lack adequate standardization in the neonatal period.<\/jats:p>","DOI":"10.3390\/jcm14145068","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T11:25:17Z","timestamp":1752751517000},"page":"5068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hemostasis Laboratory Diagnostics in Newborns"],"prefix":"10.3390","volume":"14","author":[{"given":"Chiara","family":"Gorio","sequence":"first","affiliation":[{"name":"Pediatric Onco-Hematology Unit, Children\u2019s Hospital, ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8078-8402","authenticated-orcid":false,"given":"Angelo Claudio","family":"Molinari","sequence":"additional","affiliation":[{"name":"Thrombosis and Hemostasis Unit, IRCCS Istituto Giannina Gaslini Children\u2019s Hospital, 16147 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-460X","authenticated-orcid":false,"given":"Tiziano","family":"Martini","sequence":"additional","affiliation":[{"name":"Regional Reference Centre for Inherited Bleeding and Thrombotic Disorders, Transfusion Medicine\u2014Citt\u00e0 della Salute e della Scienza University Hospital, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Center for Hemorrhagic and Thrombotic Diseases, Foundation University Hospital \u201cA. Gemelli\u201d IRCCS, 00136 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Albrici","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hematology Unit, Children\u2019s Hospital, ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Carracchia","sequence":"additional","affiliation":[{"name":"Pediatric Onco-Hematology Unit, Children\u2019s Hospital, ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8508-1636","authenticated-orcid":false,"given":"Antonella","family":"Ierardi","sequence":"additional","affiliation":[{"name":"Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-6384","authenticated-orcid":false,"given":"Marzia","family":"Leotta","sequence":"additional","affiliation":[{"name":"Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Portesi","sequence":"additional","affiliation":[{"name":"Clinical Chemistry Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, 25123 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2395-2691","authenticated-orcid":false,"given":"Monica","family":"Sacco","sequence":"additional","affiliation":[{"name":"Center for Hemorrhagic and Thrombotic Diseases, Foundation University Hospital \u201cA. Gemelli\u201d IRCCS, 00136 Rome, Italy"},{"name":"Department of Transitional Medicine and Surgery, Catholic University of the Sacred Heart, 00153 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Strangio","sequence":"additional","affiliation":[{"name":"Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-4028","authenticated-orcid":false,"given":"Maria Elisa","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-8201","authenticated-orcid":false,"given":"Rita Carlotta","family":"Santoro","sequence":"additional","affiliation":[{"name":"Hemostasis and Thrombosis Unit, Azienda Ospedaliero Universitaria Renato Dulbecco, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Saracco, P., and Rivers, R.P.A. 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