{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:54:12Z","timestamp":1785790452100,"version":"3.56.0"},"reference-count":42,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and Objectives: Polycystic ovary syndrome (PCOS) is associated with an elevated risk of impaired mental health and psychiatric disorders, such as depression and anxiety. Physical factors like weight and hirsutism, as well as psychological factors, such as self-esteem and coping strategies, are all known to have an influence on mental health status. Aim: To assess psychological symptoms in women with and without PCOS, by use of the well-established, validated self-report questionnaire: Symptom Checklist-90-Revised (SCL-90); to determine the reliability of the SCL-90 for assessment of PCOS patients. Design: Prospective case-control study. Methods: Psychological symptoms were assessed using the German version of the SCL-90 in 31 PCOS women and 31 healthy controls. To test the impact of various parameters on numerical outcome parameters, correlation analyses were conducted. Results: PCOS women revealed significantly increased SCL-90 scores in seven out of the nine subscales (hostility subscale, anxiety subscale, depression subscale, paranoid ideation subscale, psychoticism subscale, somatization subscale, interpersonal sensitivity subscale, obsessive compulsive subscale), as well as in all three global indices (p &lt; 0.05). SCL-90 scores were significantly positively correlated with perceived total stress and perceived helplessness and significantly negatively correlated with perceived self-efficacy (p &lt; 0.05). Conclusions: PCOS women experienced higher levels of psychological symptoms including depressive and anxiety symptoms. Higher perceived stress, higher perceived helplessness and lower self-efficacy were associated with more psychological symptoms. Hence, there is a need to support PCOS women with their emotional regulation and coping strategies.<\/jats:p>","DOI":"10.3390\/jcm14145103","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T11:12:34Z","timestamp":1752837154000},"page":"5103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mental Health as Assessed by the Symptom Checklist 90 (SCL-90) Scores in Women with and Without Polycystic Ovary Syndrome"],"prefix":"10.3390","volume":"14","author":[{"given":"Marie-Louise","family":"Marschalek","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Division of Gynecologic Endocrinology and Reproductive Medicine of the Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1772-6695","authenticated-orcid":false,"given":"Rodrig","family":"Marculescu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Institute of Immunology, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schneeberger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Division of Gynecologic Endocrinology and Reproductive Medicine of the Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-1101","authenticated-orcid":false,"given":"Julian","family":"Marschalek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Division of Gynecologic Endocrinology and Reproductive Medicine of the Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0012-9029","authenticated-orcid":false,"given":"Marlene","family":"Hager","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Division of Gynecologic Endocrinology and Reproductive Medicine of the Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-2620","authenticated-orcid":false,"given":"Robert","family":"Krysiak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyk\u00f3w 18, 40-752 Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-5262","authenticated-orcid":false,"given":"Johannes","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Clinical Division of Gynecologic Endocrinology and Reproductive Medicine of the Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1093\/humrep\/dew218","article-title":"The prevalence and phenotypic features of polycystic ovary syndrome: A systematic review and meta-analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/humupd\/dms029","article-title":"Emotional distress is a common risk in women with polycystic ovary syndrome: A systematic review and meta-analysis of 28 studies","volume":"18","author":"Boivin","year":"2012","journal-title":"Hum. Reprod. Update"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1093\/humrep\/dep031","article-title":"Prevalence and implications of anxiety in polycystic ovary syndrome: Results of an internet-based survey in Germany","volume":"24","author":"Benson","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00737-020-01043-x","article-title":"The mental health of women with polycystic ovary syndrome: A systematic review and meta-analysis","volume":"24","author":"Yin","year":"2021","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhang, J., Zheng, X., Lu, W., Guo, J., Chen, F., and Liu, C. (2024). Depression, anxiety and self-esteem in adolescent girls with polycystic ovary syndrome: A systematic review and meta-analysis. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1399580"},{"key":"ref_6","first-page":"e70352","article-title":"Fertility Stress, Psychological Resilience, and Depressive Symptoms in Women with Polycystic Ovary Syndrome","volume":"16","author":"Zhang","year":"2024","journal-title":"Cureus"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/humrep\/deae016","article-title":"Anxiety, depression, and body image among infertile women with and without polycystic ovary syndrome","volume":"39","author":"Jannink","year":"2024","journal-title":"Hum. Reprod."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tabassum, F., Jyoti, C., Sinha, H.H., Dhar, K., and Akhtar, M.S. (2021). Impact of polycystic ovary syndrome on quality of life of women in correlation to age, basal metabolic index, education and marriage. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0247486"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1530\/eje.1.02024","article-title":"Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome","volume":"153","author":"Hahn","year":"2005","journal-title":"Eur. J. Endocrinol. Eur. Fed. Endocr. Soc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1017\/S0033291718002076","article-title":"Depression, anxiety and perceived stress in women with and without PCOS: A community-based study","volume":"49","author":"Damone","year":"2019","journal-title":"Psychol. Med."},{"key":"ref_11","unstructured":"(2025, July 10). Available online: https:\/\/www.monash.edu\/__data\/assets\/pdf_file\/0003\/3379521\/Evidence-Based-Guidelines-2023.pdf."},{"key":"ref_12","first-page":"604","article-title":"Delayed Diagnosis and a Lack of Information Associated with Dissatisfaction in Women with Polycystic Ovary Syndrome","volume":"102","author":"Teede","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1192\/bjp.128.3.280","article-title":"The SCL-90 and the MMPI: A step in the validation of a new self-report scale","volume":"128","author":"Derogatis","year":"1976","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Gomez, R., Stavropoulos, V., Zarate, D., and Palikara, O. (2021). Symptom Checklist-90-Revised: A structural examination in relation to family functioning. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0247902"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/humrep\/dei409","article-title":"Determinants of emotional distress in women with polycystic ovary syndrome","volume":"21","author":"Elsenbruch","year":"2006","journal-title":"Hum. Reprod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/0167482X.2017.1311319","article-title":"Psychological distress, anger and quality of life in polycystic ovary syndrome: Associations with biochemical, phenotypical andsocio-demographic factors","volume":"39","author":"Borghi","year":"2018","journal-title":"J. Psychosom. Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s11596-017-1799-4","article-title":"Mental health status assessment in polycystic ovarian syndrome infertility patients: A pilot study","volume":"37","author":"Li","year":"2017","journal-title":"Curr. Med Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s12020-018-1692-3","article-title":"Psychiatric disorders in women with polycystic ovary syndrome: A systematic review and meta-analysis","volume":"62","author":"Brutocao","year":"2018","journal-title":"Endocrine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0895-4356(98)00108-5","article-title":"The equivalence of SF-36 summary health scores estimated using standard and country-specific algorithms in 10 countries: Results from the IQOLA Project. International Quality of Life Assessment","volume":"51","author":"Ware","year":"1998","journal-title":"J. Clin. Epidemiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group (2004). Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum. Reprod., 19, 41\u201347.","DOI":"10.1093\/humrep\/deh098"},{"key":"ref_21","first-page":"185","article-title":"The Symptom Check-List-90-R (SCL-90-R): A German validation study","volume":"9","author":"Schmitz","year":"2000","journal-title":"Qual. Life Res. Int. J. Qual. Life Asp. Treat. Care Rehabil."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1093\/humrep\/den227","article-title":"Psychological implications of infertility in women with polycystic ovary syndrome","volume":"23","author":"Tan","year":"2008","journal-title":"Hum. Reprod."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1210\/jcem-21-11-1440","article-title":"Clinical assessment of body hair growth in women","volume":"21","author":"Ferriman","year":"1961","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1046\/j.1365-4362.1997.00099.x","article-title":"A comparison of current acne grading systems and proposal of a novel system","volume":"36","author":"Doshi","year":"1997","journal-title":"Int. J. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hager, M., Ott, J., Marschalek, J., Marschalek, M.L., Kinsky, C., Marculescu, R., and Dewailly, D. (2022). Basal and dynamic relationships between serum anti-Mullerian hormone and gonadotropins in patients with functional hypothalamic amenorrhea, with or without polycystic ovarian morphology. Reprod. Biol. Endocrinol., 20.","DOI":"10.1186\/s12958-022-00961-y"},{"key":"ref_27","unstructured":"(2012). Medical Laboratories. Requirements for Quality and Competence (Standard No. ISO 15189). Available online: https:\/\/www.bmwet.gv.at\/dam\/jcr:609dec19-693e-4302-b826-9d3b1ba44970\/Leitfaden."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Marschalek, M.L., Marculescu, R., Schneeberger, C., Marschalek, J., Dewailly, D., and Ott, J. (2023). A case-control study about markers of stress in normal-\/overweight women with polycystic ovary syndrome and in controls. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1173422"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3050487","DOI":"10.1155\/2020\/3050487","article-title":"Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study","volume":"2020","author":"Guo","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/humrep\/del069","article-title":"Metformin treatment of polycystic ovary syndrome improves health-related quality-of-life, emotional distress and sexuality","volume":"21","author":"Hahn","year":"2006","journal-title":"Hum. Reprod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1080\/09513590.2021.1942452","article-title":"The prevalence of anxiety and depression of different severity in women with polycystic ovary syndrome: A meta-analysis","volume":"37","author":"Wang","year":"2021","journal-title":"Gynecol. Endocrinol. Off. J. Int. Soc. Gynecol. Endocrinol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e944746","DOI":"10.12659\/MSM.944746","article-title":"Type D Personality, Stress Levels, and Coping Strategies in Women with Androgenetic Alopecia and Polycystic Ovary Syndrome","volume":"30","author":"Dybciak","year":"2024","journal-title":"Med. Sci. Monit."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Fairfax, A., Brehaut, J., Colman, I., Sikora, L., Kazakova, A., Chakraborty, P., Potter, B.K., and Canadian Inherited Metabolic Diseases Research Network (2019). A systematic review of the association between coping strategies and quality of life among caregivers of children with chronic illness and\/or disability. BMC Pediatr., 19.","DOI":"10.1186\/s12887-019-1587-3"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1530\/EC-17-0053","article-title":"Understanding and supporting women with polycystic ovary syndrome: A qualitative study in an ethnically diverse UK sample","volume":"6","author":"Hadjiconstantinou","year":"2017","journal-title":"Endocr. Connect."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/jehp.jehp_1008_20","article-title":"The status of relationship between coping strategies and quality of life in women with polycystic ovary syndrome","volume":"10","author":"Morshedi","year":"2021","journal-title":"J. Educ. Health Promot."},{"key":"ref_37","first-page":"203","article-title":"Stress, Depression, Sexual Function, and Alexithymia in Infertile Females with and without Polycystic Ovary Syndrome: A Case-Control Study","volume":"13","author":"Basirat","year":"2019","journal-title":"Int. J. Fertil. Steril."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Dybciak, P., Humeniuk, E., Raczkiewicz, D., Krakowiak, J., Wdowiak, A., and Bojar, I. (2022). Anxiety and Depression in Women with Polycystic Ovary Syndrome. Medicina, 58.","DOI":"10.3390\/medicina58070942"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00404-019-05391-7","article-title":"Differences between infertile women with and without PCOS in terms of anxiety, coping styles, personality traits, and social adjustment: A case-control study","volume":"301","author":"Basirat","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Romanazzo, S., Rometsch, C., Marangoni, A., Guiducci, S., and Cosci, F. (2024). Psychological features of systemic sclerosis: Results from an observational study. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1473587"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/08039488.2020.1715475","article-title":"Clinical evaluation of psychiatric and behavioral disorders in adolescents with epilepsy: A cross-sectional study","volume":"74","author":"Kuzman","year":"2020","journal-title":"Nord. J. Psychiatry"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Vigano, C.A., Beltrami, M.M., Bosi, M.F., Zanello, R., Valtorta, M., and Maconi, G. (2018). Alexithymia and Psychopathology in Patients Suffering From Inflammatory Bowel Disease: Arising Differences and Correlations to Tailoring Therapeutic Strategies. Front. Psychiatry, 9.","DOI":"10.3389\/fpsyt.2018.00324"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/14\/5103\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:11:47Z","timestamp":1760033507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/14\/5103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":42,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["jcm14145103"],"URL":"https:\/\/doi.org\/10.3390\/jcm14145103","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,18]]}}}