{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:32:17Z","timestamp":1760059937546,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Intramural pregnancy (IMP) is a rare type of ectopic pregnancy where the embryo implants within the uterine myometrium. This condition carries a high risk of massive hemorrhage, uterine rupture, and potentially life-threatening complications. Methods: We present a case of a 35-year-old patient who underwent in vitro fertilization (IVF) and was diagnosed with an IMP located in the back-isthmian portion of the uterus by ultrasound scan. Results: We performed a conservative treatment approach based on the gestational sac location and the patient\u2019s stable clinical condition and desire for future fertility. We first administered mifepristone 600 mg, followed by intracavitary methotrexate under ultrasound guidance. Although originally planned, a uterine artery embolization was not performed due to the evidence of bilateral anastomoses between the uterine and ovarian arteries. Progressive reabsorption of pregnancy was observed over the course of 8 months. Conclusions: Non-surgical management can be considered for IMP, thus allowing fertility preservation.<\/jats:p>","DOI":"10.3390\/jcm14145146","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T09:33:53Z","timestamp":1753090433000},"page":"5146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ectopic Intramural Isthmic Pregnancy: Case Report"],"prefix":"10.3390","volume":"14","author":[{"given":"Eloisa Maria","family":"Mariani","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6413-3845","authenticated-orcid":false,"given":"Diletta","family":"Guglielmi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy"},{"name":"Specialization School in Obstetrics and Gynecology, University of Milano-Bicocca, 20100 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Camponovo","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy"},{"name":"Specialization School in Obstetrics and Gynecology, University of Milano-Bicocca, 20100 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Gambino","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy"},{"name":"Specialization School in Obstetrics and Gynecology, University of Milano-Bicocca, 20100 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7532-3267","authenticated-orcid":false,"given":"Alessandra","family":"Inzoli","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy"},{"name":"Specialization School in Obstetrics and Gynecology, University of Milano-Bicocca, 20100 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Leni","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Passoni","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, 20900 Monza, Italy"},{"name":"School of Medicine and Surgery, University of Milano-Bicocca, 20100 Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s00404-019-05379-3","article-title":"Intramural ectopic pregnancy following pelvic adhesion: Case report and literature review","volume":"300","author":"Zhang","year":"2019","journal-title":"Arch. 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