{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:24:25Z","timestamp":1785835465536,"version":"3.56.0"},"reference-count":65,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Servicio de Adicciones (PMD\/UPCCA-Valencia)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objective: Fentanyl plays a pivotal role in the opioid epidemic, defined by four waves of overdose deaths. To analyse fentanyl research trends, examining its links to mental health, pharmaceutical development, healthcare, diseases, and pathophysiology within the broader social and health context of the time. Methods: To understand the evolution of scientific publications on fentanyl and its relationship to the opioid crisis, a search using Web of Science Core Collection and PubMed was conducted. A total of 53,670 documents were retrieved related to opioid scientific production, among which 1423 articles (3%) focused specifically on fentanyl. The 21,546 MeSH terms identified in these documents were analysed by publication year and specific fields: Psychiatry and Psychology, Chemicals and Drugs, Healthcare, Diseases, and Phenomena and Processes. R-statistical\/FactoMineR libraries were used for the correspondence analysis. Results: In the first overdose death wave, research focused on improving therapies and reducing side effects. The second wave emphasised detoxification methods with naltrexone, methadone, and behavioural therapies. The third wave addressed psychological treatments and HIV-syringe-sharing prevention. The fourth wave prioritised less addictive analogues and understanding consumer profiles to combat the epidemic. Conclusions: Fentanyl research has evolved alongside real-world challenges, reinforcing the connection between patients\u2019 needs, healthcare professionals\u2019 roles, illicit users, policymakers, and the research community\u2019s contributions to addressing both therapeutic use and its broader societal impact. These findings highlight the necessity for an interdisciplinary approach to scientific research integrating prevention, treatment, education, legal reform, and social support, emphasising the need for public health policies and collaborative research to mitigate its impact.<\/jats:p>","DOI":"10.3390\/jcm14155187","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:44:45Z","timestamp":1753184685000},"page":"5187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fentanyl Research: Key to Fighting the Opioid Crisis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-5620","authenticated-orcid":false,"given":"Cristina","family":"Rius","sequence":"first","affiliation":[{"name":"UISYS Group, Department of History of Science and Information Science, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"},{"name":"Unit Associated with the Interuniversity Institute for Advanced Research on the Evaluation of Science and the University (INAECU), UC3M-UAM, 28903 Madrid, Spain"},{"name":"Spanish National Centre for Cardiovascular Research (CNIC), 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-386X","authenticated-orcid":false,"given":"Antonio Eleazar","family":"Serrano-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Estudios M\u00e9tricos de Informaci\u00f3n (LEMI), Departamento de Biblioteconom\u00eda y Documentaci\u00f3n, Universidad Carlos III de Madrid, 37008 Madrid, Spain"},{"name":"Instituto Interuniversitario de Investigaci\u00f3n Avanzada sobre Evaluaci\u00f3n de la Ciencia y la Universidad (INAECU), Universidad Carlos III de Madrid, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4697-7832","authenticated-orcid":false,"given":"Rut","family":"Lucas-Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"UISYS Group, Department of History of Science and Information Science, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"},{"name":"Unit Associated with the Interuniversity Institute for Advanced Research on the Evaluation of Science and the University (INAECU), UC3M-UAM, 28903 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), 28029 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Pandiella-Dominique","sequence":"additional","affiliation":[{"name":"Laboratorio de Estudios M\u00e9tricos de Informaci\u00f3n (LEMI), Departamento de Biblioteconom\u00eda y Documentaci\u00f3n, Universidad Carlos III de Madrid, 37008 Madrid, Spain"},{"name":"Instituto Interuniversitario de Investigaci\u00f3n Avanzada sobre Evaluaci\u00f3n de la Ciencia y la Universidad (INAECU), Universidad Carlos III de Madrid, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6860-8069","authenticated-orcid":false,"given":"Carlos","family":"Garc\u00eda-Zorita","sequence":"additional","affiliation":[{"name":"Laboratorio de Estudios M\u00e9tricos de Informaci\u00f3n (LEMI), Departamento de Biblioteconom\u00eda y Documentaci\u00f3n, Universidad Carlos III de Madrid, 37008 Madrid, Spain"},{"name":"Instituto Interuniversitario de Investigaci\u00f3n Avanzada sobre Evaluaci\u00f3n de la Ciencia y la Universidad (INAECU), Universidad Carlos III de Madrid, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Valderrama-Zuri\u00e1n","sequence":"additional","affiliation":[{"name":"UISYS Group, Department of History of Science and Information Science, Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain"},{"name":"Unit Associated with the Interuniversity Institute for Advanced Research on the Evaluation of Science and the University (INAECU), UC3M-UAM, 28903 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"j4792","DOI":"10.1136\/bmj.j4792","article-title":"Overprescribing Is Major Contributor to Opioid Crisis","volume":"359","author":"Makary","year":"2017","journal-title":"BMJ"},{"key":"ref_2","unstructured":"National Institute on Drug Abuse (NIDA) (2024, July 25). 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