{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:34:41Z","timestamp":1760060081317,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Lymphomatoid papulosis (LyP) is a primary cutaneous CD30-positive T-cell lymphoproliferative disorder presenting with self-healing erythematous papulonodular lesions that may ulcerate and scar. Treatment varies by lesion extent, location, and severity. Case Report: We describe a 57-year-old man with acral LyP successfully treated with chlormethine gel (CG). The patient experienced impaired second finger mobility for over 3 months due to an ulcerated nodular mass. After 3 months of CG treatment, complete remission, symptom resolution, and full joint recovery were achieved. Six months post-treatment, the patient remained in remission. Conclusions: This case underscores the effectiveness of CG in achieving sustained remission in acral LyP, suggesting its potential as a treatment option for this rare condition.<\/jats:p>","DOI":"10.3390\/jcm14155338","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T08:00:41Z","timestamp":1753776041000},"page":"5338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical Chlormethine Gel in the Treatment of Lymphomatoid Papulosis: A Case Report and Literature Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Miriam","family":"Teoli","sequence":"first","affiliation":[{"name":"Porphyria and Rare Diseases Unit, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2025-0982","authenticated-orcid":false,"given":"Martina","family":"Caviglia","sequence":"additional","affiliation":[{"name":"Dermatologic Unit, Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, La Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Rega","sequence":"additional","affiliation":[{"name":"Dermatologic Unit, Department of Clinical Internal, Anesthesiologic and Cardiovascular Sciences, La Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Porphyria and Rare Diseases Unit, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5772-4937","authenticated-orcid":false,"given":"Marco","family":"Ardig\u00f2","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Humanitas Research Hospital-IRCCS, 20089 Rozzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Desmond","family":"Mandel","sequence":"additional","affiliation":[{"name":"Porphyria and Rare Diseases Unit, San Gallicano Dermatological Institute-IRCCS, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13030\/qt4xt046c9","DOI":"10.5070\/D32412042443","article-title":"Lymphomatoid papulosis","volume":"24","author":"Wiznia","year":"2018","journal-title":"Dermatol. Online J."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Nowicka, D., Mertowska, P., Mertowski, S., Hymos, A., Forma, A., Michalski, A., Morawska, I., Hrynkiewicz, R., Nied\u017awiedzka-Rystwej, P., and Grywalska, E. (2022). Etiopathogenesis, diagnosis, and treatment strategies for lymphomatoid papulosis with particular emphasis on the role of the immune system. Cells, 11.","DOI":"10.3390\/cells11223697"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Fricke, T., Kempf, W., Sch\u00f6n, M.P., and Mitteldorf, C. (2025). Histologic and immunohistochemical patterns in lymphomatoid papulosis: A systematic review of published cases. Dermatopathology, 12.","DOI":"10.3390\/dermatopathology12010006"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5070\/D35DS430MG","article-title":"Lymphomatoid papulosis localized to the face","volume":"12","author":"Dalle","year":"2006","journal-title":"Dermatol. Online J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jaad.2009.02.025","article-title":"Acral lymphomatoid papulosis","volume":"62","author":"Yancovitz","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jaad.2009.01.034","article-title":"Localized lymphomatoid papulosis","volume":"62","author":"Hsu","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/jdv.15931","article-title":"Lymphomatoid papulosis: An update and review","volume":"34","author":"Walsh","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1182\/blood.V95.12.3653","article-title":"Primary and secondary cutaneous CD30+ lymphoproliferative disorders: A report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment","volume":"95","author":"Bekkenk","year":"2000","journal-title":"Blood"},{"key":"ref_9","first-page":"199","article-title":"Lymphomatoid papulosis","volume":"18","author":"Wagner","year":"2020","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1111\/bjd.13920","article-title":"Recommendations for treatment of lymphomatoid papulosis with methotrexate: A report from the Dutch Cutaneous Lymphoma Group","volume":"173","author":"Bruijn","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1182\/blood-2011-05-351346","article-title":"EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: Lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma","volume":"118","author":"Kempf","year":"2011","journal-title":"Blood"},{"key":"ref_12","first-page":"137","article-title":"First-line treatment in lymphomatoid papulosis: A retrospective multicentre study","volume":"43","author":"Servitje","year":"2017","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s13555-021-00539-3","article-title":"Chlormethine Gel for the Treatment of Skin Lesions in All Stages of Mycosis Fungoides Cutaneous T-Cell Lymphoma: A Narrative Review and International Experience","volume":"11","author":"Geskin","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e15683","DOI":"10.1111\/dth.15683","article-title":"Topical chlormethine gel in the treatment of mycosis fungoides: A single-center real-life experience and systematic review of the literature","volume":"35","author":"Laghi","year":"2022","journal-title":"Dermatol. Ther."},{"key":"ref_15","first-page":"826","article-title":"Successful treatment of lymphomatoid papulosis with chlormethine gel","volume":"22","author":"Dege","year":"2024","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.3760\/cma.j.issn.0366-6999.20131271","article-title":"Regional lymphomatoid papulosis successfully controlled by interferon alpha-2b and nitrogen mustard solution","volume":"126","author":"Shang","year":"2013","journal-title":"Chin. Med. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/1346-8138.15276","article-title":"Nitrogen mustard gel-induced inflammation triggers lymphomatoid papulosis in patients with mycosis fungoides","volume":"47","author":"Trager","year":"2020","journal-title":"J. Dermatol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/15\/5338\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:17:42Z","timestamp":1760033862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/15\/5338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":17,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jcm14155338"],"URL":"https:\/\/doi.org\/10.3390\/jcm14155338","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,7,29]]}}}