{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:58:26Z","timestamp":1783486706080,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Patients with primary angle-closure disease (PACD), those with no history of acute angle-closure glaucoma or laser iridotomy, rarely present with prominent corneal endothelial cell density (CECD) loss. To identify factors associated with decreased CECD in PACD, anterior segment parameters were compared in patients with PACD and normal CECD and patients with PACD and decreased CECD, using anterior segment optical coherence tomography (AS-OCT). Patients and Methods: Ten patients with PACD and CECD of less than 1500\/mm2 without a history of cataract surgery, acute angle-closure glaucoma, or prior laser glaucoma procedures were identified at the Kyorin Eye Center from January 2018 to July 2023. Patients with an obvious corneal guttata or apparent corneal edema were also excluded. Seventeen patients with PACD and normal CECD (normal CECD group) were used as the control. Simultaneous biometry of all anterior segment structures, including the cornea, anterior chamber, and iris, were assessed using a swept-source AS-OCT system. Results: Corneal curvature radius was significantly larger in the decreased CECD group compared with the corneal refractive power in the normal CECD group (p = 0.022, Mann\u2013Whitney test). However, no significant differences were detected in other anterior segment morphology parameters. Multiple regression analysis with CECD as the dependent variable revealed that a large corneal curvature radius was a significant explanatory variable associated with corneal endothelial loss. Conclusions: Flattened corneal curvature may be a risk factor for corneal endothelial loss in patients with PACD.<\/jats:p>","DOI":"10.3390\/jcm14155364","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T16:16:10Z","timestamp":1753805770000},"page":"5364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Morphological Features in Eyes with Prominent Corneal Endothelial Cell Loss Associated with Primary Angle-Closure Disease"],"prefix":"10.3390","volume":"14","author":[{"given":"Yumi","family":"Kusumi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine, Mitaka 181-8611, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0414-4439","authenticated-orcid":false,"given":"Masashi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine, Mitaka 181-8611, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine, Mitaka 181-8611, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-9599","authenticated-orcid":false,"given":"Masakazu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kyorin University School of Medicine, Mitaka 181-8611, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/eye.1990.53","article-title":"The corneal endothelium","volume":"4","author":"Tuft","year":"1990","journal-title":"Eye"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"108495","DOI":"10.1016\/j.exer.2021.108495","article-title":"Diseases of the corneal endothelium","volume":"205","author":"Jeang","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jtos.2024.08.003","article-title":"Evolution of therapeutic strategy based on oxidant-antioxidant balance for Fuchs endothelial corneal dystrophy","volume":"34","author":"Wu","year":"2024","journal-title":"Ocul. Surf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.survophthal.2017.11.002","article-title":"Glaucoma-associated corneal endothelial cell damage: A review","volume":"63","author":"Janson","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0161-6420(82)34744-2","article-title":"Corneal endothelial changes in primary acute angle-closure glaucoma","volume":"89","author":"Bigar","year":"1982","journal-title":"Ophthalmology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/IJG.0b013e3181fc800a","article-title":"Corneal status in primary angle-closure glaucoma with a history of acute attack","volume":"21","author":"Chen","year":"2012","journal-title":"J. Glaucoma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1442-9071.2012.02885.x","article-title":"Management algorithms for primary angle closure disease","volume":"41","author":"Thomas","year":"2013","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ophtha.2015.10.049","article-title":"Primary Angle Closure. Preferred Practice Pattern\u00ae guidelines","volume":"123","author":"Prum","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ajo.2021.06.033","article-title":"Evaluation of the Diagnostic Performance of Swept-Source Anterior Segment Optical Coherence Tomography in Primary Angle Closure Disease","volume":"233","author":"Ma","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1046\/j.1442-9071.2003.00710.x","article-title":"Corneal endothelial status in the subtypes of primary angle closure glaucoma","volume":"31","author":"Sihota","year":"2003","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1007\/s00417-023-06109-x","article-title":"Factors associated with severe corneal endothelial damage following acute primary angle closure in Chinese subjects","volume":"261","author":"Li","year":"2023","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ajo.2006.01.070","article-title":"Inferior corneal decompensation following laser peripheral iridotomy in the superior iris","volume":"142","author":"Lim","year":"2006","journal-title":"Am. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1136\/bjo.2007.120261","article-title":"Argon laser iridotomy-induced bullous keratopathy a growing problem in Japan","volume":"91","author":"Ang","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/ICO.0b013e31802c9e19","article-title":"National survey on bullous keratopathy in Japan","volume":"26","author":"Shimazaki","year":"2007","journal-title":"Cornea"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1136\/bjo.2008.142786","article-title":"Argon laser iridotomy-induced bullous keratopathy","volume":"93","author":"Narayanaswamy","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/aos.12367","article-title":"Laser iridotomy and the corneal endothelium: A systemic review","volume":"92","author":"Wang","year":"2014","journal-title":"Acta Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s10384-018-0569-6","article-title":"Effect of laser peripheral iridotomy using argon and neodymium-YAG lasers on corneal endothelial cell density: 7-year longitudinal evaluation","volume":"62","author":"Ono","year":"2018","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/bjophthalmol-2020-315811","article-title":"Long-term effect of YAG laser iridotomy on corneal endothelium in primary angle closure suspects: A 72-month randomised controlled study","volume":"105","author":"Liao","year":"2021","journal-title":"Br. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/IJG.0000000000000669","article-title":"Evaluation of angle closure as a risk factor for reduced corneal endothelial cell density","volume":"26","author":"Varadaraj","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_20","first-page":"525","article-title":"Characteristics of the corneal endothelium across the primary angle closure disease spectrum","volume":"59","author":"Verma","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.2147\/OPTH.S309005","article-title":"Association between anterior chamber angle and corneal endothelial cell density in chronic angle closure","volume":"15","author":"Soebijantoro","year":"2021","journal-title":"Clin. Ophthalmol."},{"key":"ref_22","first-page":"292","article-title":"Preoperative, intraoperative and postoperative complications of small incision cataract surgery for cataract and primary angle-closure diseases","volume":"34","author":"Sakai","year":"2017","journal-title":"J. Eye"},{"key":"ref_23","first-page":"81","article-title":"Grading for corneal endothelial damage","volume":"18","author":"Kinoshita","year":"2014","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00417-014-2636-0","article-title":"Sectoral variations of iridocorneal angle width and iris volume in Chinese Singaporeans: A swept-source optical coherence tomography study","volume":"252","author":"Tun","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_25","first-page":"279","article-title":"An epidemiological study on the prevalence of the narrow chamber angle in Japanese","volume":"95","author":"Okabe","year":"1991","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jcjo.2020.12.010","article-title":"Clinical characteristics, rates of blindness, and geographic features of PACD in China","volume":"56","author":"Zhang","year":"2021","journal-title":"Can. J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Petrela, R.B., Chhetri, C.D., Najafi, A., Zhang, Z., Rinkoski, T.A., Wieben, E.D., Fautsch, M.P., Chakraborty, S., Millen, A.E., and Patel, S.P. (2025). Associations between measures of oestrogen exposure and severity of Fuchs endothelial corneal dystrophy. BMJ Open Ophthalmol., 10.","DOI":"10.1136\/bmjophth-2024-001884"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kumar, V., Deshpande, N., Parekh, M., Wong, R., Ashraf, S., Zahid, M., Hui, H., Miall, A., Kimpton, S., and Price, M.O. (2024). Estrogen genotoxicity causes preferential development of Fuchs endothelial corneal dystrophy in females. Redox Biol., 69.","DOI":"10.1016\/j.redox.2023.102986"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1073\/pnas.1912546116","article-title":"Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected","volume":"117","author":"Liu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/15\/5364\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:18:19Z","timestamp":1760033899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/15\/5364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":29,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jcm14155364"],"URL":"https:\/\/doi.org\/10.3390\/jcm14155364","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,29]]}}}