{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:33:50Z","timestamp":1760060030221,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: High-risk percutaneous coronary interventions (HR-PCIs) often require mechanical circulatory support (MCS) to maintain hemodynamic stability. Intra-aortic balloon pump (IABP) and percutaneous left ventricular assist device (PLVAD) are two commonly used MCS devices that differ in their mechanisms. We aimed to evaluate and compare the clinical outcomes associated with IABP and PLVAD use in HR-PCIs without cardiogenic shock. Methods: We conducted a search of PubMed, Scopus, Cochrane, Mendeley, Web of Science, and Embase to identify relevant randomized controlled trials and cohort studies, and we included 13 studies for the systematic review and meta-analysis. The primary goal was to define the difference in early mortality (in-hospital and 30-day mortality), major bleeding, and major adverse cardiovascular event (MACE) components (cardiogenic shock, acute kidney injury (AKI), and stroke\/TIA) in IABP and PLVAD. We used a random-effects model with the Mantel\u2013Haenszel statistical method to estimate odds ratios (ORs) and 95% confidence intervals. Results: Among 1 trial and 12 cohort studies (35,554 patients; 30,351 IABP and 5203 PLVAD), HR-PCI with IABP was associated with a higher risk of early mortality (OR = 1.53, 95% CI [1.21, 1.94]) and cardiogenic shock (OR = 2.56, 95% CI [1.98, 3.33]) when compared to PLVAD. No significant differences were found in the rates of arrhythmia, major bleeding, AKI, stroke\/TIA, or hospital length of stay. Conclusions: In high-risk PCIs, PLVAD use is associated with lower early mortality and cardiogenic shock risk compared to IABP, with no significant differences in other major outcomes.<\/jats:p>","DOI":"10.3390\/jcm14155430","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:46:55Z","timestamp":1754383615000},"page":"5430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Outcomes of Intra-Aortic Balloon Pump Versus Percutaneous Left Ventricular Assist Device in High-Risk Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0777-6542","authenticated-orcid":false,"given":"Dhiran","family":"Sivasubramanian","sequence":"first","affiliation":[{"name":"Department of Cardiology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virushnee","family":"Senthilkumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Mayo Clinic Hospital, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3967-4507","authenticated-orcid":false,"given":"Nithish","family":"Nanda Palanisamy","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Coimbatore Medical College, Coimbatore 641018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashi","family":"Bilgaiyan","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Pune 411018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6960-7822","authenticated-orcid":false,"given":"Smrti","family":"Aravind","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Coimbatore Medical College, Coimbatore 641018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sri Drishaal","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4270-8802","authenticated-orcid":false,"given":"Aishwarya","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Coimbatore Medical College, Coimbatore 641018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8207-8762","authenticated-orcid":false,"given":"Sathwik","family":"Sanil","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sri Ramakrishna Hospital, Coimbatore 641018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthick","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Christian Medical College, Vellore 632004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharssini","family":"Kamaladasan","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Coimbatore Medical College, Coimbatore 641018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hashwin","family":"Pilathodan","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Coimbatore Medical College, Coimbatore 641018, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiruba","family":"Shankar","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Christian Medical College, Vellore 632004, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e003405","DOI":"10.1161\/CIRCINTERVENTIONS.115.003405","article-title":"High-Risk Percutaneous Coronary Interventions in Modern Day Clinical Practice: Current Concepts and Challenges","volume":"8","author":"Bass","year":"2015","journal-title":"Circ. 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