{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:36:09Z","timestamp":1760060169398,"version":"build-2065373602"},"reference-count":43,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Pneumatic dilation (PD) is a widely used treatment modality in the management of achalasia. It is particularly relevant in regions where many centers lack access to advanced therapeutic modalities. Therefore, we aimed to assess the effectiveness and safety of PD in our local region. Methods: This study retrospectively analyzed patients with achalasia that underwent PD from 1\/2013 to 12\/2019. The diagnosis of achalasia was established on the grounds of clinical symptoms, radiological and endoscopic findings, and esophageal manometry. Data on patient\u2019s clinical characteristics, dilation technique and postprocedural follow-up were collected and statistically analyzed. Procedure effectiveness was defined as the postprocedural Eckardt score \u2264 3. Results: PD significantly reduced frequency of dysphagia, regurgitation, and retrosternal pain (p &lt; 0.001). Body-weight increased significantly one month and one year after the procedure (p &lt; 0.001). The procedural success rate was 100%. No severe complications were reported. Conclusions: PD is an effective and safe treatment modality in the management of achalasia. The study limitations include a single center design with the small number of participants, not all of whom underwent manometry, gender disproportion, absence of non-responders, and a short follow-up.<\/jats:p>","DOI":"10.3390\/jcm14155448","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:46:55Z","timestamp":1754383615000},"page":"5448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of Patients with Achalasia Following Pneumatic Dilation Treatment: A Single Center Experience"],"prefix":"10.3390","volume":"14","author":[{"given":"Viktorija","family":"Sablji\u0107","sequence":"first","affiliation":[{"name":"Institute of Emergency Medicine of \u0160ibenik-Knin County, Narodnog Preporoda 1, 22000 \u0160ibenik, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorotea","family":"Bo\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Split, Spin\u010di\u0107eva 1, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damir","family":"Ali\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Split, Spin\u010di\u0107eva 1, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5970-707X","authenticated-orcid":false,"given":"\u017darko","family":"Ardali\u0107","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Split, Spin\u010di\u0107eva 1, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3777-7350","authenticated-orcid":false,"given":"Ivna","family":"Oli\u0107","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Split, Spin\u010di\u0107eva 1, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damir","family":"Bonacin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Split, Spin\u010di\u0107eva 1, 21000 Split, Croatia"},{"name":"School of Medicine, University of Split, \u0160oltanska 2A, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"\u017daja","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University Hospital Split, Spin\u010di\u0107eva 1, 21000 Split, Croatia"},{"name":"Department of Health Studies, University of Split, Ru\u0111era Bo\u0161kovi\u0107a 35, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1001\/jama.2015.2996","article-title":"Achalasia: A systematic review","volume":"313","author":"Pandolfino","year":"2015","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1442-2050.2011.01207.x","article-title":"The Kagoshima consensus on esophageal achalasia","volume":"25","author":"Triadafilopoulos","year":"2012","journal-title":"Dis. Esophagus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1136\/gut.27.8.986","article-title":"Balloon dilation in achalasia: A new dilator","volume":"27","author":"Cox","year":"1986","journal-title":"Gut"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1053\/j.gastro.2008.07.022","article-title":"Achalasia: A new clinically relevant classification by high-resolution manometry","volume":"135","author":"Pandolfino","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1365-2036.2006.03079.x","article-title":"Review article: The management of achalasia\u2014A comparison of different treatment modalities","volume":"24","author":"Lake","year":"2006","journal-title":"Aliment. Pharm. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5763","DOI":"10.3748\/wjg.v12.i36.5763","article-title":"Non-surgical treatment of esophageal achalasia","volume":"12","author":"Annese","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1007\/s10620-008-0637-8","article-title":"Meta-analysis of randomized and controlled treatment trials for achalasia","volume":"54","author":"Wang","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00455-007-9115-2","article-title":"Pneumatic balloon dilation therapy is as effective as esophagomyotomy for achalasia","volume":"23","author":"Emami","year":"2008","journal-title":"Dysphagia"},{"key":"ref_9","first-page":"301","article-title":"Treatment of achalasia in the era of high-resolution manometry","volume":"28","author":"Torresan","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cgh.2009.09.020","article-title":"Long-term outcome of pneumatic dilation in the treatment of achalasia","volume":"8","author":"Hulselmans","year":"2010","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cgh.2011.10.032","article-title":"Conservative management of esophageal perforations during pneumatic dilation for idiopathic esophageal achalasia","volume":"10","author":"Vanuytsel","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1055\/s-0029-1244080","article-title":"Peroral endoscopic myotomy (POEM) for esophageal achalasia","volume":"42","author":"Inoue","year":"2010","journal-title":"Endoscopy"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"E195","DOI":"10.1055\/s-0034-1391668","article-title":"Peroral endoscopic myotomy (POEM) vs. laparoscopic Heller myotomy (LHM) for the treatment of Type III achalasia in 75 patients: A multicenter comparative study","volume":"3","author":"Kumbhari","year":"2015","journal-title":"Endosc. Int. Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1055\/a-1160-5549","article-title":"Endoscopic management of gastrointestinal motility disorders\u2013Part 1: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"52","author":"Weusten","year":"2020","journal-title":"Endoscopy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e13287","DOI":"10.1111\/nmo.13287","article-title":"Evaluating the reliability and construct validity of the Eckardt symptom score as a measure of achalasia severity","volume":"30","author":"Taft","year":"2018","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/0016-5085(92)91428-7","article-title":"Predictors of outcome in patients with achalasia treated by pneumatic dilation","volume":"103","author":"Eckardt","year":"1992","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/1751-2980.12922","article-title":"Sex differences in symptoms, high-resolution manometry values and efficacy of peroral endoscopic myotomy in Chinese patients with achalasia","volume":"21","author":"Xu","year":"2020","journal-title":"J. Dig. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1540\/jsmr.59.14","article-title":"Clinical characteristics and manometric findings of esophageal achalasia-a systematic review regarding differences among three subtypes","volume":"59","author":"Katsumata","year":"2023","journal-title":"J. Smooth Muscle Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e13932","DOI":"10.1111\/nmo.13932","article-title":"Achalasia subtypes can be identified with functional luminal imaging probe (FLIP) panometry using a supervised machine learning process","volume":"33","author":"Carlson","year":"2021","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/1319-3767.126317","article-title":"Efficacy of pneumatic dilation in Saudi achalasia patients","volume":"20","author":"Aljebreen","year":"2014","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1572-0241.2005.40093.x","article-title":"Long-term outcome of pneumatic dilation in the treatment of achalasia","volume":"100","author":"Karamanolis","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"doy046","DOI":"10.1093\/dote\/doy046","article-title":"Weight loss in achalasia is determined by its phenotype","volume":"31","author":"Patel","year":"2018","journal-title":"Dis. Esophagus"},{"key":"ref_23","first-page":"doy105","article-title":"Pneumatic dilation versus laparoscopic Heller\u2019s myotomy in the treatment of achalasia: Systematic review and meta-analysis based on randomized controlled trials","volume":"32","author":"Bernardo","year":"2019","journal-title":"Dis. Esophagus"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/j.1365-2036.2011.04816.x","article-title":"Review article: An analysis of the efficacy, perforation rates and methods used in pneumatic dilation for achalasia","volume":"34","author":"Katzka","year":"2011","journal-title":"Alim Pharm. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/gut.50.6.765","article-title":"Timed barium oesophagram: Better predictor of long term success after pneumatic dilation in achalasia than symptom assessment","volume":"50","author":"Vaezi","year":"2002","journal-title":"Gut"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1136\/gut.12.4.268","article-title":"Treatment of achalasia with pneumatic dilations","volume":"12","author":"Vantrappen","year":"1971","journal-title":"Gut"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.21037\/aoe.2020.04.02","article-title":"Pneumatic balloon dilation for achalasia\u2014How and why I do it","volume":"3","author":"Bright","year":"2020","journal-title":"Ann. Esophagus"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.gastrohep.2013.05.009","article-title":"Dilataci\u00f3n neum\u00e1tica en el tratamiento de pacientes con acalasia","volume":"36","year":"2013","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_29","first-page":"15","article-title":"Traitement de l\u2019achalasie par dilation pneumatique: Exp\u00e9rience locale sur une s\u00e9rie de 41 cas","volume":"55","author":"Honein","year":"2007","journal-title":"J. M\u00e9d. Liban."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e13548","DOI":"10.1111\/nmo.13548","article-title":"Efficacy and safety of pneumatic dilation in achalasia: A systematic review and meta-analysis","volume":"31","author":"Prins","year":"2019","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1572-0241.2006.00385.x","article-title":"Repeated pneumatic dilations as long-term maintenance therapy for esophageal achalasia","volume":"101","author":"Zerbib","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1442-2050.2008.00874.x","article-title":"Endoscopic pneumatic balloon dilation in primary achalasia: Predictive factors, complications, and long-term follow-up","volume":"22","author":"Tuset","year":"2009","journal-title":"Dis. Esophagus"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e29441","DOI":"10.1097\/MD.0000000000029441","article-title":"The comparisons of different therapeutic modalities for idiopathic achalasia: A systematic review and network meta-analysis","volume":"101","author":"Shiu","year":"2022","journal-title":"Medicine"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5152\/tjg.2023.22178","article-title":"Pneumatic dilation in geriatric achalasia patients","volume":"34","author":"Tenlik","year":"2023","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_35","first-page":"508","article-title":"Outcome of sequential dilation in achalasia cardia patients: A prospective cohort study","volume":"19","author":"Misra","year":"2022","journal-title":"Esophagus Off. J. Jpn. Esophageal Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"862","DOI":"10.34172\/aim.2021.129","article-title":"Safety and efficacy of graded gradual pneumatic balloon dilation in idiopathic achalasia patients: A 24-year single-center experience","volume":"24","author":"Fazlollahi","year":"2021","journal-title":"Arch. Iran. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/jama.2019.8859","article-title":"Effect of peroral endoscopic myotomy vs. pneumatic dilation on symptom severity and treatment outcomes among treatment-naive patients with achalasia: A randomized clinical trial","volume":"322","author":"Ponds","year":"2019","journal-title":"J. Am. Med. Assoc."},{"key":"ref_38","first-page":"28","article-title":"Graded pneumatic dilation in subtype I and II achalasia: Long-term experience in a single center","volume":"35","author":"Torresan","year":"2022","journal-title":"Ann. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/gut.39.1.9","article-title":"Risk factors of oesophageal perforation during pneumatic dilation for achalasia","volume":"39","author":"Borotto","year":"1996","journal-title":"Gut"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF01296777","article-title":"Pneumatic dilation or esophagomyotomy treatment for idiopathic achalasia: Clinical outcomes and cost analysis","volume":"38","author":"Parkman","year":"1993","journal-title":"Dig. Dis. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1111\/j.1572-0241.2002.05771.x","article-title":"Long term results of pneumatic dilation in achalasia followed for more than 5 years","volume":"97","author":"West","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S2468-1253(22)00300-4","article-title":"Peroral endoscopic myotomy versus pneumatic dilation in treatment-naive patients with achalasia: 5-year follow-up of a randomised controlled trial","volume":"7","author":"Kuipers","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.gie.2023.01.004","article-title":"Short-term outcomes after peroral endoscopic myotomy, Heller myotomy, and pneumatic dilation in patients with achalasia: A nationwide analysis","volume":"97","author":"Haseeb","year":"2023","journal-title":"Gastrointest. Endosc."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/15\/5448\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:21:54Z","timestamp":1760034114000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/15\/5448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,2]]},"references-count":43,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jcm14155448"],"URL":"https:\/\/doi.org\/10.3390\/jcm14155448","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,8,2]]}}}