{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T22:41:01Z","timestamp":1793572861465,"version":"4.5.0"},"reference-count":36,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Acute kidney injury (AKI) frequently occurs following major liver resection, adversely affecting both short- and long-term outcomes. This study aimed to determine the incidence of AKI post-hepatectomy and identify relevant pre- and intraoperative risk factors. Our secondary objectives were to develop a predictive score for postoperative AKI and assess the associations between AKI, chronic kidney disease (CKD), and 1-year mortality. Methods: This was a retrospective study in a cancer referral center in Marseille, France, from 2018 to 2022. Results: Among 169 patients, 55 (32.5%) experienced AKI. Multivariate analysis revealed several independent risk factors for postoperative AKI, including age, body mass index, the use of angiotensin-converting enzyme inhibitors\/angiotensin receptor blockers, time to liver resection, intraoperative shock, and bile duct reconstruction. Neoadjuvant chemotherapy was protective. The AKIMEBO score was developed, with a threshold of \u226515.6, demonstrating a sensitivity of 89.5%, specificity of 76.4%, positive predictive value of 61.8%, and negative predictive value of 94.4%. AKI was associated with increased postoperative morbidity and one-year mortality following major hepatectomy. Conclusion: AKI is a common complication post-hepatectomy. Factors such as time to liver resection and intraoperative shock management present potential clinical intervention points. The AKIMEBO score can provide a valuable tool for postoperative risk stratification.<\/jats:p>","DOI":"10.3390\/jcm14155452","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:46:55Z","timestamp":1754383615000},"page":"5452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Incidence and Predictive Factors of Acute Kidney Injury After Major Hepatectomy: Implications for Patient Management in Era of Enhanced Recovery After Surgery (ERAS) Protocols"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1215-9744","authenticated-orcid":false,"given":"Henri","family":"Mingaud","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Manuel","family":"de Guibert","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5481-2926","authenticated-orcid":false,"given":"Jonathan","family":"Garnier","sequence":"additional","affiliation":[{"name":"Department of Surgery, Paoli-Calmettes Institute, 13273 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Chow-Chine","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Bisbal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgita","family":"Alisauskaite","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Sannini","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-758X","authenticated-orcid":false,"given":"Marc","family":"L\u00e9one","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, H\u00f4pital Nord, 13015 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Tezier","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Tourret","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Cambon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Ewald","sequence":"additional","affiliation":[{"name":"Department of Surgery, Paoli-Calmettes Institute, 13273 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Pouliquen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lam","family":"Nguyen Duong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Paoli-Calmettes Institute, 13273 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Ettori","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Turrini","sequence":"additional","affiliation":[{"name":"Department of Surgery, Paoli-Calmettes Institute, 13273 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Faucher","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1711-463X","authenticated-orcid":false,"given":"Djamel","family":"Mokart","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Paoli-Calmettes Institute, 232 Bd Sainte Marguerite, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/bjs.11236","article-title":"Mortality after Liver Surgery in Germany","volume":"106","author":"Filmann","year":"2019","journal-title":"Br. 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