{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:34:41Z","timestamp":1760060081660,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder frequently associated with metabolic and inflammatory disturbances. Due to its antioxidant and anti-inflammatory properties, pomegranate juice has been proposed as a potential adjunctive therapy in managing PCOS. To evaluate the effects of pomegranate juice on hormonal, inflammatory, and lipid parameters and body mass index (BMI) in women with PCOS. Methods: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted following PRISMA guidelines. Comprehensive searches were performed in electronic databases including Medline, Scopus, Web of Science, Cochrane CENTRAL, and Embase from inception to July 2025, using keywords and MeSH terms related to \u201cpolycystic ovary syndrome\u201d and \u201cpomegranate juice\u201d without language restrictions. The primary outcomes were changes in serum testosterone, luteinizing hormone (LH), high-sensitivity C-reactive protein (hs-CRP), lipid profile parameters (HDL, LDL, triglycerides, and total cholesterol), and body mass index (BMI). Results: Four RCTs published between 2020 and 2023, encompassing 128 women with PCOS, were included. The meta-analysis revealed significant reductions in testosterone (MD: \u22120.05; 95% CI: \u22120.07 to \u22120.03; p &lt; 0.0001; I2 = 0%, two studies, 85 participants) and hs-CRP (SMD: \u22120.85; 95% CI: \u22121.35 to \u22120.35; p = 0.0009; I2 = 20%, two studies, 85 participants), along with increases in HDL (MD: 6.21; 95% CI: 2.43 to 10.00; p = 0.001; I2 = 0%, two studies, 85 participants) and reductions in triglycerides (MD: \u221223.30; 95% CI: \u221245.19 to \u22121.42; p = 0.04; I2 = 0%, two studies, 85 participants). No significant changes were observed in LH, LDL, total cholesterol, or BMI. Conclusions: Pomegranate juice demonstrates promising effects as an adjunctive intervention in women with PCOS, improving androgen levels, inflammatory markers, and certain lipid parameters. Further long-term studies are needed to confirm these findings.<\/jats:p>","DOI":"10.3390\/jcm14155458","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:46:55Z","timestamp":1754383615000},"page":"5458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Pomegranate Juice on Androgen Levels, Inflammation and Lipid Profile in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"14","author":[{"given":"Vit\u00f3ria","family":"Silveira","sequence":"first","affiliation":[{"name":"School of Medicine, Universidade do Extremo Sul Catarinense (UNESC), Crici\u00fama 88806-000, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Braz","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidade do Extremo Sul Catarinense (UNESC), Crici\u00fama 88806-000, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-075X","authenticated-orcid":false,"given":"Antonio Jose","family":"Grande","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidade Estadual de Mato Grosso do Sul (UEMS), Campo Grande 79804-970, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1175-5583","authenticated-orcid":false,"given":"Tamy","family":"Colonetti","sequence":"additional","affiliation":[{"name":"Translational Biomedicine Laboratory, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Crici\u00fama 88806-000, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8883-287X","authenticated-orcid":false,"given":"Maria Laura","family":"Rodrigues Uggioni","sequence":"additional","affiliation":[{"name":"Translational Biomedicine Laboratory, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Crici\u00fama 88806-000, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"da Silveira Prestes","sequence":"additional","affiliation":[{"name":"Translational Biomedicine Laboratory, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Crici\u00fama 88806-000, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-5548","authenticated-orcid":false,"given":"Leonardo","family":"Roever","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Brazilian Evidence-Based Health Network, Uberl\u00e2ndia 38400-384, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdemira","family":"Santina Dagostin","sequence":"additional","affiliation":[{"name":"Translational Biomedicine Laboratory, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Crici\u00fama 88806-000, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6124-2538","authenticated-orcid":false,"given":"Maria In\u00eas","family":"da Rosa","sequence":"additional","affiliation":[{"name":"Translational Biomedicine Laboratory, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense (UNESC), Crici\u00fama 88806-000, SC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1210\/clinem\/dgad463","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"108","author":"Teede","year":"2023","journal-title":"J. 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