{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:52:45Z","timestamp":1792803165047,"version":"4.5.0"},"reference-count":15,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Acute pancreatitis (AP) is a highly variable inflammatory condition that can lead to severe complications and high mortality, particularly in its severe forms. Early risk stratification is essential; however, the delayed availability of traditional scoring systems often limits its effectiveness. This study aimed to evaluate the clinical utility of systemic inflammation indices as early predictors of severity in patients with acute pancreatitis. Methods: A retrospective, observational study was conducted among patients diagnosed with acute pancreatitis, classified according to the revised Atlanta criteria. Upon admission, systemic inflammation indices were calculated from complete blood count parameters, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI). Severity was assessed using the APACHE II score. Statistical analysis involved Kruskal\u2013Wallis tests, Dunn\u2019s post hoc comparisons, ROC curve analysis, logistic regression for odds ratios (ORs), and Spearman correlations. Results: SII, NLR, MLR, SIRI, and AISI showed statistically significant associations with AP severity (p &lt; 0.05). MLR and SIRI exhibited the highest predictive performance (AUC = 0.74). ORs for severe pancreatitis were: MLR = 19.10, SIRI = 7.50, NLR = 7.33, AISI = 5.12, and SII = 4.10. All four indices also demonstrated moderate positive correlations with APACHE II scores. Conclusions: Systemic inflammation indices are simple, cost-effective, and accessible tools that can aid in the early identification of patients at high risk for severe acute pancreatitis. Their integration into clinical practice may enhance early decision-making and improve patient outcomes.<\/jats:p>","DOI":"10.3390\/jcm14155465","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:46:55Z","timestamp":1754383615000},"page":"5465","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Systemic Inflammation Indices as Early Predictors of Severity in Acute Pancreatitis"],"prefix":"10.3390","volume":"14","author":[{"given":"Jos\u00e9 Francisco","family":"Araiza-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-6724","authenticated-orcid":false,"given":"Brandon","family":"Bautista-Becerril","sequence":"additional","affiliation":[{"name":"Laboratorio de Neumogen\u00f3mica, 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Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0838-5123","authenticated-orcid":false,"given":"Asya","family":"Zubillaga-Mares","sequence":"additional","affiliation":[{"name":"Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d, Mexico City 14080, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0807-7104","authenticated-orcid":false,"given":"Edgar","family":"Abarca-Rojano","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0496-2920","authenticated-orcid":false,"given":"Samuel","family":"Sevilla-Fuentes","sequence":"additional","affiliation":[{"name":"Hospital General de Zona 1 \u201cEmilio Varela Luj\u00e1n\u201d, Zacatecas 98000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis \u00c1ngel","family":"Mendoza-Vargas","sequence":"additional","affiliation":[{"name":"Hospital General de Zona 1 \u201cEmilio Varela Luj\u00e1n\u201d, Zacatecas 98000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4361-821X","authenticated-orcid":false,"given":"Espiridi\u00f3n","family":"Ramos-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertha","family":"Bertha\u00fad-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital General de Zacatecas \u201cLuz Gonz\u00e1lez Cos\u00edo\u201d, Zacatecas 98160, 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Aguilar","sequence":"additional","affiliation":[{"name":"Hospital General de Zona 1 \u201cEmilio Varela Luj\u00e1n\u201d, Zacatecas 98000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1136\/gutjnl-2016-313595","article-title":"Acute pancreatitis: Recent advances through randomised trials","volume":"66","author":"Hallensleben","year":"2017","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/MPA.0b013e3180cac24b","article-title":"Direct medical costs of acute pancreatitis hospitalizations in the United States","volume":"35","author":"Fagenholz","year":"2007","journal-title":"Pancreas"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00423-020-01944-6","article-title":"Severe acute pancreatitis: Surgical indications and 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