{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:19:04Z","timestamp":1772648344761,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Childhood cancer is considered one of the main causes of mortality and morbidity worldwide. There is strong evidence of the oral toxic effects of oncologic treatments, but their incidence is difficult to determine. The novel therapeutic strategies in Pediatric Oncology have led to increased survival in this population, resulting in an increased incidence of long-term effects, which diminish the patient\u2019s quality of life. Methods: The search for articles started on 5 November 2024 and ended on 5 December 2024. Following the PRISMA Statement, a total of 1266 articles were obtained, from which 13 were selected for review. All articles were considered to be of high quality. The antineoplastic treatments used in them were chemotherapy, radiotherapy, surgery and immune therapy. Results: Most articles were cohorts and case controls. Only one case report was obtained. The results revealed that the most prevalent sequelae in the pediatric population after antineoplastic treatment were enamel alterations, microdontia, dental caries, periodontal disease, gingivitis, hyposalivation, alteration of the oral microbiome, alteration of mandibular bone density and malocclusion. The lesions are different depending on the therapy used. Conclusions: Oncologic treatments in children with cancer cause multiple oral sequelae such as microdontia, dental caries, enamel alterations, salivary gland alterations, mucositis and root resorption. It cannot be concluded which therapy has the most detrimental effect as each has a different mechanism of action in the oral cavity.<\/jats:p>","DOI":"10.3390\/jcm14155479","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:46:55Z","timestamp":1754383615000},"page":"5479","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oral and Dental Sequelae After Oncological Treatment in Children: A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Lidia","family":"Torrecillas-Quiles","sequence":"first","affiliation":[{"name":"Department of Integrated Pediatric Dentistry, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8046-3736","authenticated-orcid":false,"given":"Inmaculada","family":"G\u00f3mez-R\u00edos","sequence":"additional","affiliation":[{"name":"Department of Integrated Pediatric Dentistry, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3544-4045","authenticated-orcid":false,"given":"Irene","family":"Jim\u00e9nez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Oncohematolog\u00eda Pedi\u00e1trica, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9623-1393","authenticated-orcid":false,"given":"Ildefonso","family":"Serrano-Belmonte","sequence":"additional","affiliation":[{"name":"Department of Integrated Prosthodontics, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9113-8416","authenticated-orcid":false,"given":"Antonio Jos\u00e9","family":"Ortiz-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Integrated Pediatric Dentistry, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain"},{"name":"Biomedical Research Institute of Murcia Pascual Parilla-IMIB, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Serna-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Integrated Pediatric Dentistry, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain"},{"name":"Biomedical Research Institute of Murcia Pascual Parilla-IMIB, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.22206\/cysa.2023.v7i2.pp69-76","article-title":"C\u00e1ncer infantil: Lo que debemos saber","volume":"7","author":"Valdez","year":"2023","journal-title":"Cienc. 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