{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:24:25Z","timestamp":1788189865134,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Nowadays, intravascular lithotripsy (IVL) has emerged as a novel technique for treatment of vascular calcifications, first in coronary and then in peripheral arteries. In the current literature there is little evidence that describes IVL as an effective and safe solution in treating severe aortic and aorto-iliac calcifications. The aim of this study is to report current available data about the use of IVL in treating aortic and aorto-iliac calcified lesions and its application in facilitating other endovascular procedures. Methods: the present review was conducted and reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) Guidelines. Preliminary searches were conducted on MEDLINE and Pubmed from January 2015 to February 2025. Studies were divided into 3 main categories depending on the location of calcifications and the type of treatment: IVL in visceral and infrarenal obstructive disease (group 1), IVL in aorto-iliac obstructive disease (group 2), IVL used to facilitate other endovascular procedures. Main primary outcomes in the perioperative period were technical and clinical successes and perioperative complications. Primary outcomes at 30 days and mid-term (2 years) were overall survival, limb salvage rate, primary patency, primary assisted patency, secondary patency, and residual stenosis. Results: Sixteen studies were identified for a total of 1674 patients. Technical and clinical successes were 100%, with low rates of perioperative complications. Dissection rate reaches up to 16.1% in some studies, without any differences compared to plain old balloon angioplasty (POBA) alone (22.8%; p = 0.47). At 30 days, limb salvage and survival rates were 100%. At 2 years, primary patency, assisted primary patency, and secondary patency were 95%, 98%, and 100%, respectively, with no difference compared to IVL + stenting. Conclusions: IVL has emerged as a novel approach to treat severe calcified lesions in visceral and aorto-iliac atherosclerotic disease and to facilitate other endovascular procedures. This technique seems to offer satisfactory early and mid-term outcomes in terms of primary, primary assisted patency, and secondary patency with low complication rates.<\/jats:p>","DOI":"10.3390\/jcm14155493","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:46:55Z","timestamp":1754383615000},"page":"5493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intravascular Lithotripsy in the Aorta and Iliac Vessels: A Literature Review of the Past Decade"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8779-9120","authenticated-orcid":false,"given":"Nicola","family":"Troisi","sequence":"first","affiliation":[{"name":"Vascular Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Cisanello Hospital, Via Roma 67, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1363-489X","authenticated-orcid":false,"given":"Giulia","family":"Bertagna","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Cisanello Hospital, Via Roma 67, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Pierozzi","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Cisanello Hospital, Via Roma 67, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Artini","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Cisanello Hospital, Via Roma 67, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Berchiolli","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Cisanello Hospital, Via Roma 67, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/CRD.0000000000000502","article-title":"Coronary Intravascular Lithotripsy","volume":"32","author":"Sreenivasan","year":"2024","journal-title":"Cardiol. Rev."},{"key":"ref_2","first-page":"710","article-title":"Efficacy of intravascular lithotripsy (IVL) in coronary stenosis with severe calcification: A multicenter systematic review and meta-analysis","volume":"103","author":"Sagris","year":"2024","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/CRD.0000000000000483","article-title":"Intravascular Lithotripsy in Peripheral Artery Disease","volume":"32","author":"Malik","year":"2024","journal-title":"Cardiol. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jcin.2021.04.010","article-title":"Disrupt PAD III Investigators. Intravascular Lithotripsy for Peripheral Artery Calcification: 30-Day Outcomes From the Randomized Disrupt PAD III Trial","volume":"14","author":"Tepe","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.jcin.2021.03.036","article-title":"Principles of Intravascular Lithotripsy for Calcific Plaque Modification","volume":"14","author":"Kereiakes","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_6","first-page":"959","article-title":"Efficacy and safety of intravascular lithotripsy for the treatment of peripheral arterial disease: An individual patient-level pooled data analysis","volume":"95","author":"Madhavan","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Pitoulias, A.G., Taneva, G.T., Avranas, K., Abu Bakr, N., Pitoulias, G.A., and Donas, K.P. (2024). Use of Rotational Atherectomy-Assisted Balloon Angioplasty in the Treatment of Isolated Below-the-Knee Atherosclerotic Lesions in Patients with Chronic Limb-Threatening Ischemia. J. Clin. Med., 13.","DOI":"10.3390\/jcm13051346"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"406","DOI":"10.23736\/S0021-9509.22.12535-8","article-title":"Intravascular lithotripsy: A powerful tool to treat peripheral artery calcifications","volume":"64","author":"Vedani","year":"2023","journal-title":"J. Cardiovasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101709","DOI":"10.1016\/j.jvscit.2024.101709","article-title":"Novel approach to treating calcified infrarenal aortic stenosis using intravascular lithotripsy without stenting","volume":"11","author":"Allievi","year":"2024","journal-title":"J. Vasc. Surg. Cases Innov. Tech."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101106","DOI":"10.1016\/j.jvscit.2023.101106","article-title":"Intravascular lithotripsy angioplasty for treatment of atherosclerotic coral-reef occlusion of the infrarenal aorta and its bifurcation","volume":"9","author":"Piazza","year":"2023","journal-title":"J. Vasc. Surg. Cases Innov. Tech."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102536","DOI":"10.1016\/j.jaccas.2024.102536","article-title":"IVUS-Guided Intravascular Lithotripsy of the Juxtarenal and Visceral Coral Reef Aorta","volume":"29","author":"Elger","year":"2024","journal-title":"JACC Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"ytab102","DOI":"10.1093\/ehjcr\/ytab102","article-title":"Novel use of intravascular lithotripsy for coral reef aorta: A case report","volume":"5","author":"Chag","year":"2021","journal-title":"Eur. Heart J.-Case Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"101507","DOI":"10.1016\/j.jvscit.2024.101507","article-title":"Kissing intravascular lithotripsy in iliac in-stent restenosis related to underexpanded stents","volume":"10","author":"Troisi","year":"2024","journal-title":"J. Vasc. Surg. Cases Innov. Tech."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jcin.2019.09.055","article-title":"First Report of Peripheral Balloon-Expandable Stent Underexpansion Treated by Intravascular Lithotripsy","volume":"13","author":"Honton","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Konstantinou, N., Tsilimparis, N., and Stavroulakis, K. (J. Endovasc. Ther, 2024). Intravascular Lithotripsy and Aortic Bare-Metal Stenting: A Low-Profile Solution for the Treatment of Heavily Calcified Aorto-Iliac Disease, J. Endovasc. Ther, online ahead of print.","DOI":"10.1177\/15266028241270650"},{"key":"ref_16","first-page":"e66874","article-title":"Covered Endovascular Reconstruction of Aortic Bifurcation Facilitated by Intravascular Lithotripsy With Shockwave Balloon: A Case Report","volume":"16","author":"Misuraca","year":"2024","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/17085381241244570","article-title":"Selective assisted intravascular lithotripsy for complex aorto-iliac calcific lesions","volume":"33","author":"Zenunaj","year":"2025","journal-title":"Vascular"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ Br. Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia","volume":"58","author":"Conte","year":"2019","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_20","first-page":"E76","article-title":"Safety and efficacy of lithoplasty in treating severely calcified iliac artery disease: A single center experience","volume":"16","author":"Radaideh","year":"2019","journal-title":"Vasc. Dis. Manag."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Fazzini, S., Turriziani, V., Lomazzi, C., Forcella, E., Grazioli, L., Allievi, S., Mastrorilli, D., Settembrini, A.M., Martelli, E., and Trimarchi, S. (J. Vasc. Surg, 2025). Mid-term outcomes of Shockwave intravascular lithotripsy in the IVLIAC Registry for the treatment of calcified iliac occlusive disease, J. Vasc. Surg, online ahead of print.","DOI":"10.1016\/j.jvs.2025.04.025"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Fazzini, S., Pennetta, F.F., Torsello, G., Turriziani, V., Vona, S., Ascoli Marchetti, A., Ippoliti, A., Austermann, M., and Bosiers, M.J. (J. Endovasc. Ther, 2024). Intravascular Iliac Artery Lithotripsy to Facilitate Aortic Endograft Delivery: Midterm Results of a Dual-Center Experience, J. Endovasc. Ther, online ahead of print.","DOI":"10.1177\/15266028241241246"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1024\/0301-1526\/a001133","article-title":"Intravascular lithotripsy in peripheral lesions with severe calcification and its use in TAVI procedure\u2014A meta-analysis","volume":"53","author":"Sagris","year":"2024","journal-title":"Vasa"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1016\/j.jcin.2019.03.013","article-title":"Kissing Intravascular Lithotripsy Facilitated Endovascular Repair of a Complex Saccular Abdominal Aortic Aneurysm with Narrowed Distal Aorta: A First-in-Human Report","volume":"12","author":"Khalid","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejvsvf.2024.09.005","article-title":"Integrating Intravascular Lithotripsy to Overcome Severe Aorto-Iliac Atherosclerosis in Standard Endovascular Aortic Repair: A Case Report","volume":"62","author":"Mastropaolo","year":"2024","journal-title":"EJVES Vasc. Forum."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"324","DOI":"10.23736\/S0021-9509.24.13098-4","article-title":"Open surgery of common femoral artery occlusive disease: A contemporary review","volume":"65","author":"Troisi","year":"2024","journal-title":"J. Cardiovasc. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3400\/avd.cr.16-00133","article-title":"Severe Obstructive Calcification of the Descending Aorta: A Case Report of \u201cCoral Reef Aorta\u201d","volume":"10","author":"Ishigaki","year":"2017","journal-title":"Ann. Vasc. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Florek, K., Bartoszewska, E., Biega\u0142a, S., Klimek, O., Malcharczyk, B., and K\u00fcbler, P. (2023). Rotational Atherectomy, Orbital Atherectomy, and Intravascular Lithotripsy Comparison for Calcified Coronary Lesions. J. Clin. Med., 12.","DOI":"10.3390\/jcm12237246"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/15\/5493\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:23:06Z","timestamp":1760034186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/15\/5493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,4]]},"references-count":28,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jcm14155493"],"URL":"https:\/\/doi.org\/10.3390\/jcm14155493","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,4]]}}}