{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:34:26Z","timestamp":1760060066603,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bolu Abant \u0130zzet Baysal University Scientific Research Projects (BAP)","award":["2021.08.32.1503"],"award-info":[{"award-number":["2021.08.32.1503"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Agents responsible for the initiation of autoimmune responses are still under investigation. The aim of this study was to determine Nogo-A and NfL levels in CSF samples from newly diagnosed multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD) and pseudotumour cerebri (PTC) patients positive for HHV6-A IgG autoantibody. Methods: Initial CSF samples from 42 patients were analysed by ELISA. Independent samples t tests, Mann\u2013Whitney U tests, crosstabulation with Fisher\u2019s exact tests and Pearson\/Spearman correlation analyses were used for group comparisons. Results: Anti-HHV6A IgG positivity was highest in MS, followed by NMOSD and then PTC (6.7%), but no significant difference in positivity was found among the groups (p = 0.367). No significant difference was found among the groups for NfL or Nogo-A levels (p = 0.373, p = 0.975, respectively). Anti-HHV6A negative MS cases had lower Nogo-A levels than positive cases (p = 0.046). In addition, anti-HHV6A negative PTC cases had lower Nogo-A levels than positive cases (p = 0.015). Anti-HHV6A positive MS patients had lower Nogo-A levels than the PTC positive group and this difference was very close to significant (p = 0.063). Conclusions: Anti-HHV6A positivity was found mainly in the MS group. Anti-HHV6A was found to be associated with Nogo-A levels, especially in the MS and PTC groups. Anti-HHV6A autoantibodies might play a role in the pathophysiology of MS.<\/jats:p>","DOI":"10.3390\/jcm14155497","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:46:55Z","timestamp":1754383615000},"page":"5497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nogo-A and NfL Levels in CSF from Newly Diagnosed Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder Patients Positive for Anti-HHV6-A IgG Autoantibody"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-4485","authenticated-orcid":false,"given":"\u015eeyda","family":"Karab\u00f6rk","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, Bolu Abant \u0130zzet Baysal University, G\u00f6lk\u00f6y Campus Bolu, Bolu 14030, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bihter G\u00f6k\u00e7e","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Neuroscience, Graduate School of Health Sciences Institute, Bolu Abant \u0130zzet Baysal University, Bolu 14030, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7983-4483","authenticated-orcid":false,"given":"Firdevs","family":"Ulu\u00e7","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Neuroscience, Graduate School of Health Sciences Institute, Bolu Abant \u0130zzet Baysal University, Bolu 14030, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8616-832X","authenticated-orcid":false,"given":"\u015eule","family":"Ayd\u0131n T\u00fcrko\u011flu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Bolu Abant \u0130zzet Baysal University, Bolu 14030, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Bolu Abant \u0130zzet Baysal University, Bolu 14030, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/ana.21748","article-title":"Preferential recruitment of interferon-\u03b3-expressing T H 17 cells in multiple sclerosis","volume":"66","author":"Kebir","year":"2009","journal-title":"Ann. 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