{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:01:22Z","timestamp":1782889282243,"version":"3.54.5"},"reference-count":62,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Interstitial lung disease (ILD) is a frequent complication of rheumatoid arthritis (RA), representing the most common extra-articular manifestation (with a prevalence of about 10\u201360%) and the second cause of mortality. Spondyloarthritides (SpAs) are chronic arthritides that share with RA both a similar disease burden and similar therapeutical approaches. The evaluation of ILD is challenging, given the low sensitivity of X-ray and pulmonary function tests, and the radiation exposure linked to repetitive HRCT. Lung ultrasound (LUS) has shown potential in the evaluation of ILD in autoimmune diseases. The purpose of this study is to assess the prevalence of ILD in a cohort of SpA patients (pts) using LUS in comparison with healthy subjects (HSs). The secondary aim is to evaluate potential correlations between ILD and clinical features within the SpA cohort using LUS. Methods: Consecutive SpA out-patients were examined by LUS, applying the definition for pleural line irregularity (PLI) recently provided by the OMERACT taskforce for LUS in systemic sclerosis. Seventy-one intercostal spaces were studied (14 in the anterior chest, 27 lateral and 30 posterior) in all the pts\/HS using an Esaote MyLab25 Gold US machine with a linear 7.5\u201310 MHz probe. A total pleural score was calculated. Each patient answered to Italian-validated PROs on respiratory function (Leicester and Saint-George), global health (SF-36) and dyspnea (mMRC scale). Clinical data on disease duration, disease onset, disease activity (at the moment of the examination) and methotrexate (MTX) or biologics treatment were collected from the medical records. Results: Seventy-three SpA pts (46 psoriatic arthritis -PsA- and 27 ankylosing spondylitis -AS-) and 56 HS were studied. No significant differences were demonstrated between groups (SpA vs. HS and PsA vs. AS) for age, sex, BMI and smoking habits. The total PLI score was significantly higher in SpA pts than in HS (p &lt; 0.001). A positive correlation was found between the total PLI score and the PLI score from anterior, posterior and lateral chest. The posterior region of the chest showed a higher PLI score than the anterior and lateral regions. No statistically significant differences were found between PsA and AS. MTX use was not a risk factor for PLI (no differences were found between SpA MTX+ and SpA MTX- patients). PROs (Leicester, Saint-George and SF-36) were not related to the PLI total score. A significant correlation was found only between the SF36 score and the presence of PLI in the anterior chest. PROs were instead correlated with each other, showing a good concordance for absence\/presence of symptoms. Disease activity, disease duration and age at disease-onset were not related to PLI total score. Smoking habit was found to be predictive of a significantly higher PLI score both in SpA patients and HSs. Conclusions: LUS examination shows a higher amount of PLI in SpA patients with respect to HSs. Smoking habit was the only clinical feature correlated to PLI on LUS examination in our population.<\/jats:p>","DOI":"10.3390\/jcm14165632","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:59:13Z","timestamp":1754906353000},"page":"5632","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Interstitial Lung Disease: Does It Represent a Real Comorbidity in Spondyloarthritis Patients? Results from an Ultrasound Monocentric Pilot Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-4732","authenticated-orcid":false,"given":"Andrea","family":"Delle Sedie","sequence":"first","affiliation":[{"name":"Rheumatology Unit, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Carli","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Varrecchia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Cigolini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-5729","authenticated-orcid":false,"given":"Marco","family":"Di Battista","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Esti","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Fattorini","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Calabresi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, San Donato Hospital, 52100 Arezzo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mosca","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"220210","DOI":"10.1183\/16000617.0210-2022","article-title":"Prevalence, imaging patterns and risk factors of interstitial lung disease in connective tissue disease: A systematic review and meta-analysis","volume":"32","author":"Joy","year":"2023","journal-title":"Eur. Respir. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Manfredi, A., Sambataro, G., Rai, A., Cerri, S., Sambataro, D., Vacchi, C., Cassone, G., Vancheri, C., and Sebastiani, M. (2024). Prevalence of Progressive Fibrosing Interstitial Lung Disease in Patients with Primary Sjogren Syndrome. J. Pers. Med., 14.","DOI":"10.3390\/jpm14070708"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1148\/rg.235035702","article-title":"CT-histologic correlation of the ATS\/ERS 2002 classification of idiopathic interstitial pneumonias","volume":"23","author":"Wittram","year":"2003","journal-title":"Radiographics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s10067-020-05320-z","article-title":"Rheumatoid arthritis-associated interstitial lung disease: An overview of epidemiology, pathogenesis and management","volume":"40","author":"Dai","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10067-006-0286-2","article-title":"Pulmonary involvement in ankylosing spondylitis","volume":"26","author":"Cerqueira","year":"2007","journal-title":"Clin. Rheumatol."},{"key":"ref_6","first-page":"965956","article-title":"Prevalence and Characteristics of Lung Involvement on High Resolution Computed Tomography in Patients with Ankylosing Spondylitis: A Systematic Review","volume":"2012","author":"Dehhaoui","year":"2012","journal-title":"Pulm. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Li, X., Kong, L., Li, F., Chen, C., Xu, R., Wang, H., Peng, S., Zhou, M., Li, B., and Alekseyenko, A.V. (2015). Association between Psoriasis and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0145221"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.mayocpiqo.2018.07.006","article-title":"Interstitial Pneumonia in Psoriasis","volume":"2","author":"Kawamoto","year":"2018","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"ref_9","first-page":"5919304","article-title":"Concomitant Interstitial Lung Disease with Psoriasis","volume":"2019","author":"Ishikawa","year":"2019","journal-title":"Can. Respir. J."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yue, L., Yan, Y., and Zhao, S. (2024). A bidirectional two-sample Mendelian randomization study to evaluate the relationship between psoriasis and interstitial lung diseases. BMC Pulm. Med., 24.","DOI":"10.1186\/s12890-024-03146-y"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s10067-014-2652-9","article-title":"Extra-articular manifestations in psoriatic arthritis patients","volume":"34","author":"Peluso","year":"2015","journal-title":"Clin. Rheumatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11739-020-02451-8","article-title":"Interstitial lung disease associated with psoriatic arthritis: A new disease entity?","volume":"16","author":"Bargagli","year":"2021","journal-title":"Intern. Emerg. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1007\/s00296-024-05685-3","article-title":"Exploring pulmonary involvement in newly diagnosed rheumatoid arthritis, and psoriatic arthritis: A single center study","volume":"44","author":"Winter","year":"2024","journal-title":"Rheumatol. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3899\/jrheum.2024-0252","article-title":"Interstitial lung disease in rheumatoid or psoriatic arthritis patients initiating biologics, and controls-data from five Nordic registries","volume":"51","author":"Provan","year":"2024","journal-title":"J. Rheumatol."},{"key":"ref_15","first-page":"S87","article-title":"Sonographic assessment of interstitial lung disease in patients with rheumatoid arthritis, systemic sclerosis and systemic lupus erythematosus","volume":"33","author":"Kielhauser","year":"2015","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"SI56","DOI":"10.1093\/rheumatology\/keab801","article-title":"Lung ultrasound B-lines in systemic sclerosis: Cut-off values and methodological indications for interstitial lung disease screening","volume":"61","author":"Gargani","year":"2022","journal-title":"Rheumatol. Oxf. Engl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/acr.24499","article-title":"Underdetection of Interstitial Lung Disease in Juvenile Systemic Sclerosis","volume":"74","author":"Foeldvari","year":"2022","journal-title":"Arthritis Care Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.11152\/mu.2014.2066.161.am1so2","article-title":"Comparison of a new, modified lung ultrasonography technique with high-resolution CT in the diagnosis of the alveolo-interstitial syndrome of systemic scleroderma","volume":"16","author":"Mohammadi","year":"2014","journal-title":"Med. Ultrason."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/annrheumdis-2011-201072","article-title":"Lung ultrasound for the screening of interstitial lung disease in very early systemic sclerosis","volume":"72","author":"Barskova","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/rheumatology\/kep263","article-title":"Ultrasound lung comets in systemic sclerosis: A chest sonography hallmark of pulmonary interstitial fibrosis","volume":"48","author":"Gargani","year":"2009","journal-title":"Rheumatol. Oxf. Engl."},{"key":"ref_21","first-page":"199","article-title":"Ultrasound screening for interstitial lung disease in rheumatoid arthritis","volume":"32","author":"Kielhauser","year":"2014","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1007\/s10067-012-2055-8","article-title":"Pulmonary echography in systemic sclerosis","volume":"31","author":"Zechner","year":"2012","journal-title":"Clin. Rheumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/03009742.2015.1011228","article-title":"Ultrasound signs of pulmonary fibrosis in systemic sclerosis as timely indicators for chest computed tomography","volume":"44","author":"Sperandeo","year":"2015","journal-title":"Scand. J. Rheumatol."},{"key":"ref_24","first-page":"S136","article-title":"Pleural irregularity, a new ultrasound sign for the study of interstitial lung disease in systemic sclerosis and antisynthetase syndrome","volume":"33","year":"2015","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_25","first-page":"313","article-title":"Lung Ultrasound B Lines: Etiologies and Evolution with Age","volume":"94","author":"Papa","year":"2017","journal-title":"Respir. Int. Rev. Thorac. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3899\/jrheum.180940","article-title":"Ultrasound in the Assessment of Interstitial Lung Disease in Systemic Sclerosis: A Systematic Literature Review by the OMERACT Ultrasound Group","volume":"47","author":"Gutierrez","year":"2020","journal-title":"J. Rheumatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"152406","DOI":"10.1016\/j.semarthrit.2024.152406","article-title":"Standardization of Interstitial Lung Disease Assessment by Ultrasound: Results from a Delphi Process and Web-reliability exercise by the OMERACT Ultrasound Working Group","volume":"65","author":"Terslev","year":"2024","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3899\/jrheum.120104","article-title":"Ultrasound in the assessment of pulmonary fibrosis in connective tissue disorders: Correlation with high-resolution computed tomography","volume":"39","author":"Tardella","year":"2012","journal-title":"J. Rheumatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"R134","DOI":"10.1186\/ar3446","article-title":"Utility of a simplified ultrasound assessment to assess interstitial pulmonary fibrosis in connective tissue disorders--preliminary results","volume":"13","author":"Gutierrez","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"495","DOI":"10.55563\/clinexprheumatol\/gioptt","article-title":"Lung ultrasound in patients with rheumatoid arthritis: Definition of significant interstitial lung disease","volume":"40","author":"Tardella","year":"2022","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_31","first-page":"379","article-title":"Lung ultrasonography in the evaluation of interstitial lung disease in systemic connective tissue diseases: Criteria and severity of pulmonary fibrosis\u2014Analysis of 52 patients","volume":"37","author":"Buda","year":"2016","journal-title":"Ultraschall Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11739-015-1329-y","article-title":"Lung ultrasound in systemic sclerosis: Correlation with high-resolution computed tomography, pulmonary function tests and clinical variables of disease","volume":"11","author":"Gigante","year":"2016","journal-title":"Intern. Emerg. Med."},{"key":"ref_33","first-page":"S54","article-title":"Ultrasound lung comets in systemic sclerosis: A useful tool to detect lung interstitial fibrosis","volume":"28","author":"Sedie","year":"2010","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/annrheumdis-2018-eular.6790","article-title":"Ultrasound diagnostic and predictive value of interstitial lung disease in systemic sclerosis. Diagnostic and predictive value of ultrasound in the assessment of interstitial lung disease","volume":"77","author":"Gutierrez","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Vicente-Rabaneda, E.F., Bong, D.A., Busquets-P\u00e9rez, N., and M\u00f6ller, I. (2022). Ultrasound evaluation of interstitial lung disease in rheumatoid arthritis and autoimmune diseases. Eur. J. Rheumatol., online ahead of print.","DOI":"10.5152\/eurjrheum.2024.20120"},{"key":"ref_36","first-page":"404","article-title":"Correlation of ultrasound B-lines with high-resolution computed tomography in antisynthetase syndrome","volume":"32","year":"2014","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Buda, N., Masiak, A., and Zdrojewski, Z. (2019). Utility of lung ultrasound in ANCA-associated vasculitis with lung involvement. PLoS ONE., 14.","DOI":"10.1371\/journal.pone.0222189"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Buda, N., Wojteczek, A., Masiak, A., Piskunowicz, M., Batko, W., and Zdrojewski, Z. (2021). Lung Ultrasound in the Screening of Pulmonary Interstitial Involvement Secondary to Systemic Connective Tissue Disease: A Prospective Pilot. Study Involving 180 Patients. J. Clin. Med., 10.","DOI":"10.3390\/jcm10184114"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10067-019-04686-z","article-title":"The predictive role of lung ultrasound in progression of scleroderma interstitial lung disease","volume":"39","author":"Gasperini","year":"2020","journal-title":"Clin. Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.chest.2020.03.075","article-title":"Prognostic Value of Lung Ultrasound B-Lines in Systemic Sclerosis","volume":"158","author":"Gargani","year":"2020","journal-title":"Chest"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e0566","DOI":"10.1097\/MD.0000000000010566","article-title":"Ultrasound B-lines in the evaluation of interstitial lung disease in patients with systemic sclerosis: Cut-off point definition for the presence of significant pulmonary fibrosis","volume":"97","author":"Tardella","year":"2018","journal-title":"Medicine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/RHU.0000000000000860","article-title":"Lung Ultrasound as a Screening Method for Interstitial Lung Disease in Patients With Systemic Sclerosis","volume":"25","author":"Hassan","year":"2019","journal-title":"J. Clin. Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Bruni, C., Mattolini, L., Tofani, L., Gargani, L., Landini, N., Roma, N., Lepri, G., Orlandi, M., Guiducci, S., and Bellando-Randone, S. (2022). Lung Ultrasound B-Lines in the Evaluation of the Extent of Interstitial Lung Disease in Systemic Sclerosis. Diagnostics, 12.","DOI":"10.3390\/diagnostics12071696"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.hrtlng.2022.09.011","article-title":"Screening value of lung ultrasound in connective tissue disease related interstitial lung disease","volume":"57","author":"Huang","year":"2023","journal-title":"Heart Lung"},{"key":"ref_45","first-page":"144","article-title":"Subclinical Interstitial Lung Disease in Patients with Systemic Sclerosis. A Pilot Study on the Role of Ultrasound","volume":"17","author":"Gutierrez","year":"2021","journal-title":"Reumatol. Clin. (Engl. Ed.)"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1093\/rheumatology\/kez571","article-title":"Lung ultrasound B-lines and serum KL-6 correlate with the severity of idiopathic inflammatory myositis-associated interstitial lung disease","volume":"59","author":"Wang","year":"2020","journal-title":"Rheumatology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"173","DOI":"10.7863\/jum.2003.22.2.173","article-title":"Transthoracic sonography of diffuse parenchymal lung disease: The role of comet tail artifacts","volume":"22","author":"Reissig","year":"2003","journal-title":"J. Ultrasound Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/ard.2009.108233","article-title":"The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): Validation and final selection","volume":"68","author":"Rudwaleit","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1002\/art.21972","article-title":"Classification criteria for psoriatic arthritis: Development of new criteria from a large international study","volume":"54","author":"Taylor","year":"2006","journal-title":"Arthritis Rheum."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jphys.2015.05.011","article-title":"The Leicester Cough Questionnaire","volume":"62","author":"Ward","year":"2016","journal-title":"J. Physiother."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0954-6111(06)80166-6","article-title":"The St George\u2019s Respiratory Questionnaire","volume":"85","author":"Jones","year":"1991","journal-title":"Respir Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1378\/chest.93.3.580","article-title":"Evaluation of clinical methods for rating dyspnea","volume":"93","author":"Mahler","year":"1988","journal-title":"Chest"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","article-title":"Intraclass correlations: Uses in assessing rater reliability","volume":"86","author":"Shrout","year":"1979","journal-title":"Psychol. Bull."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"117088","DOI":"10.1016\/j.jep.2023.117088","article-title":"Buyang Huanwu Decoction alleviates blood stasis, platelet activation, and inflammation and regulates the HMGB1\/NF-\u03baB pathway in rats with pulmonary fibrosis","volume":"319","author":"Feng","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"104221","DOI":"10.1016\/j.lpm.2023.104221","article-title":"Imbalance of TH17\/TREG cells in Tunisian patients with systemic sclerosis","volume":"53","author":"Amira","year":"2024","journal-title":"Presse Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Park, S.J., Hahn, H.J., Oh, S.R., and Lee, H.J. (2023). Theophylline Attenuates BLM-Induced Pulmonary Fibrosis by Inhibiting Th17 Differentiation. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021019"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1093\/rheumatology\/keaa577","article-title":"Rheumatoid arthritis related interstitial lung disease-improving outcomes over 25 years: A large multicentre UK study","volume":"60","author":"Kelly","year":"2021","journal-title":"Rheumatology"},{"key":"ref_58","first-page":"504","article-title":"Systematic review of the impact of drugs on diffuse interstitial lung disease associated with rheumatoid arthritis","volume":"17","year":"2021","journal-title":"Reumatol. Clin. (Engl. Ed.)"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/rheumatology\/keac651","article-title":"Methotrexate, leflunomide and tacrolimus use and the progression of rheumatoid arthritis-associated interstitial lung disease","volume":"62","author":"Kim","year":"2023","journal-title":"Rheumatology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"17534666221135314","DOI":"10.1177\/17534666221135314","article-title":"Protective effect of methotrexate on lung function and mortality in rheumatoid arthritis-related interstitial lung disease: A retrospective cohort study","volume":"16","author":"Kim","year":"2022","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00296-020-04773-4","article-title":"Does methotrexate cause progressive fibrotic interstitial lung disease? A systematic review","volume":"41","author":"Dawson","year":"2021","journal-title":"Rheumatol. Int."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1183\/16000617.0050-2015","article-title":"Smoking and interstitial lung diseases","volume":"24","author":"Margaritopoulos","year":"2015","journal-title":"Eur. Respir. Rev."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/16\/5632\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:27:01Z","timestamp":1760034421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/16\/5632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":62,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jcm14165632"],"URL":"https:\/\/doi.org\/10.3390\/jcm14165632","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,9]]}}}