{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:07:37Z","timestamp":1777777657560,"version":"3.51.4"},"reference-count":18,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Larval debridement therapy is used to cleanse necrotic tissue wounds and\/or decontaminate wounds that are not amenable to standard therapies. Methods: A patient was diagnosed with septic shock and multiple organ failure caused by Streptococcus pyogenes after thyroidectomy (the patient had experienced contact with a child with scarlet fever six days before admission to the hospital). As a result of systemic infection, numerous necrotic skin lesions appeared, which involved the surgical site, chest and scalp. A tracheocutaneous fistula was confirmed. Due to the ineffectiveness of typical therapy and the patient\u2019s severe clinical condition, she qualified for unconventional therapy (larval debridement therapy). Results: Larval wound debridement therapy and negative-pressure wound therapy were used for the tracheocutaneous fistula; this is the first case of this alternative therapy being described in the English-language literature. In this case, based on an analysis of the health benefits for the patient and the uncertain prognosis, larval therapy was used for a postoperative wound after strumectomy with the presence of a tracheocutaneous fistula, and negative-pressure wound therapy ultimately led to complete wound healing. Conclusions: Sepsis caused by Streptococcus pyogenes can be fulminant and often leads to complications or death, especially if it develops in the perioperative period. Larval therapy can be effectively used in cases of fistulas, such as tracheocutaneous fistulas, to prepare the wound bed for the next stage of healing using negative-pressure therapy, which ultimately leads to complete wound healing.<\/jats:p>","DOI":"10.3390\/jcm14165634","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:59:13Z","timestamp":1754906353000},"page":"5634","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Larval Debridement Therapy and Negative-Pressure Wound Therapy for an Infected Wound After Thyroidectomy\u2014A Case Report"],"prefix":"10.3390","volume":"14","author":[{"given":"Jolanta","family":"Dynarska","sequence":"first","affiliation":[{"name":"Medical Center Jolanta Dynarska, 70-953 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edyta","family":"Zagrodnik","sequence":"additional","affiliation":[{"name":"Clinical Department of Anesthesiology and Intensive Care for Adults and Children, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Kisielska","sequence":"additional","affiliation":[{"name":"Medical Center Jolanta Dynarska, 70-953 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1935-5285","authenticated-orcid":false,"given":"Anna","family":"Jurczak","sequence":"additional","affiliation":[{"name":"Department of Specialized Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6595-8250","authenticated-orcid":false,"given":"Tomasz","family":"Macha\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylwia","family":"Wieder-Huszla","sequence":"additional","affiliation":[{"name":"Department of Specialized Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.60075\/lr.v20i3.43","article-title":"Statement of the Polish Wound Management Association on larval therapyin wound management","volume":"20","author":"Dynarska","year":"2023","journal-title":"Leczenie Ran"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-12-381387-9.00002-6","article-title":"Chapter 2\u2014The Physiology of Wound Healing by the Medicinal Maggot, Lucilia sericata","volume":"39","author":"Nigam","year":"2010","journal-title":"Adv. Insect Physiol."},{"key":"ref_3","first-page":"1","article-title":"Wybrane metody leczenia ran przewlek\u0142ych","volume":"1","author":"Szewczyk","year":"2019","journal-title":"Piel\u0119gniarstwo Chir. I Angiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"Sup9a","DOI":"10.12968\/jowc.2021.30.Sup9a.VII","article-title":"Health professionals\u2019 perceptions of maggot debridement therapy","volume":"30","author":"Pajarillo","year":"2021","journal-title":"J. Wound Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.15374\/LR2018017","article-title":"Zastosowanie larw Lucilla sericata w oczyszczaniu ran. Opis trzech przypadk\u00f3w","volume":"15","author":"Karnas","year":"2018","journal-title":"Leczenie Ran"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15374\/FZ2019002","article-title":"Zasady post\u0119powania miejscowego i og\u00f3lnego w ranach\/owrzodzeniach przewlek\u0142ych obj\u0119tych procesem infekcji","volume":"10","author":"Bartoszewicz","year":"2019","journal-title":"Forum Zaka\u017ce\u0144"},{"key":"ref_7","first-page":"79","article-title":"Zastosowanie terapii podci\u015bnieniowej w medycynie w medycynie","volume":"16","author":"Popow","year":"2019","journal-title":"Leczenie Ran"},{"key":"ref_8","first-page":"1","article-title":"Negative pressure wound therapy in surgical practice: An Institutional experience from a tertiary centre of North India","volume":"94","author":"Gupta","year":"2023","journal-title":"Pol. Przegl. Chir."},{"key":"ref_9","unstructured":"\u015aciska\u0142a, K., Niedzielska, I., Buli\u0144ski, M., B\u0105k, M., and Niedzielski, D. (2025, June 17). Rola Terapii Podci\u015bnieniowej w Gojeniu Ran u Pacjent\u00f3w Oddzia\u0142u Chirurgii Szcz\u0119kowo-Twarzowej. Stomatologia News.pl 2019; dost\u0119p. Available online: https:\/\/stomatologianews.pl\/rola-terapii-podcisnieniowej-gojeniu-ran-pacjentow-oddzialu-chirurgii-szczekowo-twarzowej-etap-wstepny\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"Sup4a","DOI":"10.12968\/jowc.2024.33.Sup4a.lxxxv","article-title":"Use of biosurgery for the treatment of foot ulcers infected with therapy-resistant bacteria: A case report","volume":"33","author":"Romeyke","year":"2024","journal-title":"J. Wound Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/01.ASW.0000695776.26946.68","article-title":"Advantages of Maggot Debridement Therapy for Chronic Wounds: A Bibliographic Review","volume":"33","author":"Sherman","year":"2020","journal-title":"Adv. Ski. Wound Care"},{"key":"ref_12","first-page":"e230693","article-title":"Maggots: Antimicrobial Stewards and Life Savers","volume":"3","author":"Trottier","year":"2024","journal-title":"Ann. Intern. Med. Clin. Cases"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Bazali\u0144ski, D., Sie\u0144czak, K., Pytlak, K., Przybek-Mita, J., Pelczar, K., Leppert, W., and Wi\u0119ch, P. (2024). Pain Assessment in Patients Undergoing Maggot Debridement Therapy in the Process of Local Treatment of Chronic Wounds. J. Clin. Med., 13.","DOI":"10.3390\/jcm13030884"},{"key":"ref_14","unstructured":"Chilimoniuk, Z., Borkowska, A., Dobosz, M., Cha\u0142upnik, A., and Sobstyl, A. (2020). Przegl\u0105d dost\u0119pnych terapii w leczeniu zespo\u0142u stopy cukrzycowej. Post\u0119py w Diagnostyce Medycznej, Monografia Naukowa."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"23094990211067302","DOI":"10.1177\/23094990211067302","article-title":"Clinical outcome of Maggot Debridement Therapy followed by Negative Pressure Wound Therapy for chronic hand wound with Multi-Drug Resistant Organism infection: Two cases and review of the literature","volume":"29","author":"Phang","year":"2021","journal-title":"J. Orthop. Surg."},{"key":"ref_16","first-page":"8","article-title":"Maggot Debridement Therapy vs. Negative Pressure Wound Therapy and Their Effectiveness on Tissue Healing on Older Adults","volume":"2024","author":"Funes","year":"2024","journal-title":"Soar. J. Undergrad. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e290","DOI":"10.1097\/SLA.0000000000004960","article-title":"NPWT resource use compared with conventional wound treatment in subcutaneous abdominal wounds with healing impairment after surgery: SAWHI randomized clinical trial results","volume":"275","author":"Seidel","year":"2022","journal-title":"Ann. Surg."},{"key":"ref_18","first-page":"27","article-title":"Zastosowanie podci\u015bnieniowej metody leczenia ran (NPWT) w hospicjum domowym w hospicjum domowym","volume":"1","author":"Tomaszewski","year":"2015","journal-title":"Psychoonkologia"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/16\/5634\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:27:07Z","timestamp":1760034427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/16\/5634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":18,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jcm14165634"],"URL":"https:\/\/doi.org\/10.3390\/jcm14165634","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,9]]}}}