{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:38:17Z","timestamp":1789699097460,"version":"4.0.1"},"reference-count":62,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Orofacial pain (OFP) and headache are common and disabling conditions in people with head and neck cancer (HNC), although their clinical characteristics and underlying pain mechanisms remain poorly studied, leading to worse diagnosis and, thus, management. Therefore, this review aims to synthesize the literature regarding clinical features, pain descriptors, mechanisms, and assessment tools of OFP and\/or headache in adults with HNC. Methods: A scoping review was conducted following the Arksey and O\u2019Malley framework and reported using PRISMA-ScR guidelines. We searched PubMed, Embase, Scopus, and Web of Science. Quantitative and qualitative original studies were included. Data were charted and summarized using narrative synthesis. Results: Of 3647 records initially retrieved, 32 studies met the inclusion criteria. Most studies were observational and heterogeneous in design, population, and pain assessment methods. OFP was highly prevalent, with neuropathic descriptors (e.g., burning, electric shocks, tingling) reported in 13.1% to 64.5% of patients, although heterogeneity in study design and tools used to assess this potential pain mechanism was high. Pain was frequently localized at the tumor site, although pain in other regions beyond the head and neck was also reported. Pain intensity was generally moderate, although varied across studies. OFP and headache in HNC patients were often neuropathic in nature and contributed significantly to disability and reduced quality of life. Most articles lacked mechanistic classifications of pain, although some suggested that central sensitization may be involved in some patients. Conclusions: Orofacial pain and headache are prevalent, under-characterized symptoms in HNC patients. There is an urgent need for standardized assessments using validated tools to improve phenotyping and inform targeted treatment strategies.<\/jats:p>","DOI":"10.3390\/jcm14165722","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:43:01Z","timestamp":1755078181000},"page":"5722","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Scoping Review of Clinical Features and Mechanisms of Orofacial Pain and Headache in Patients with Head and Neck Cancer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9731-9039","authenticated-orcid":false,"given":"Ernesto","family":"Anarte-Lazo","sequence":"first","affiliation":[{"name":"Faculty of Health, UNIE University, 28015 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6235-8353","authenticated-orcid":false,"given":"Carlos","family":"Bernal-Utrera","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"ref_1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimatesof incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","unstructured":"National Institute of Dental and Craniofacial Research (2022, May 18). Oral Health in America. Reviewed May 2022, Available online: https:\/\/www.nidcr.nih.gov\/research\/oralhealthinamerica."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/1097-0347(200102)23:2<113::AID-HED1006>3.0.CO;2-W","article-title":"Health-related quality of life three years after diagnosis of head and neck cancer\u2014A longitudinal study","volume":"23","author":"Hammerlid","year":"2001","journal-title":"Head Neck"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.11607\/ofph.3176","article-title":"Orofacial Pain and Snoring\/Obstructive Sleep Apnea in Individuals with Head and Neck Cancer: A Critical Review","volume":"36","author":"Harris","year":"2022","journal-title":"J. Oral Facial Pain Headache"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.critrevonc.2015.11.010","article-title":"Pain management in head and neck cancer patients undergoing chemo-radiotherapy: Clinical practical recommendations","volume":"99","author":"Mirabile","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.5603\/rpor.100775","article-title":"Radiation-induced skin injury in the head and neck region: Pathogenesis, clinics, prevention, treatment considerations and proposal for management algorithm","volume":"29","author":"Pazdrowski","year":"2024","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1200\/OP.20.00266","article-title":"Restricted Mouth Opening in Head and Neck Cancer: Etiology, Prevention, and Treatment","volume":"16","author":"Abboud","year":"2020","journal-title":"JCO Oncol. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.3332\/ecancer.2024.1821","article-title":"Management of pain in cancer patients\u2014An update","volume":"18","author":"Daud","year":"2024","journal-title":"Ecancermedicalscience"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Greenbaum, T., and Emodi-Perlman, A. (2023). Headache and orofacial pain: A traffic-light prognosis-based management approach for the musculoskeletal practice. Front. Neurol., 14.","DOI":"10.3389\/fneur.2023.1146427"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tripleo.2005.10.041","article-title":"Pain complaint as the first symptom of oral cancer: A descriptive study","volume":"102","author":"Cuffari","year":"2006","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.anorl.2014.07.003","article-title":"Management of somatic pain induced by head-and-neck cancer treatment: Definition and assessment. Guidelines of the French Oto-Rhino-Laryngology- Head and Neck Surgery Society (SFORL)","volume":"131","author":"Binczak","year":"2014","journal-title":"Eur Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: Concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jpain.2014.07.003","article-title":"Survival patterns in squamous cell carcinoma of the head and neck: Pain as an independent prognostic factor for survival","volume":"15","author":"Anderson","year":"2014","journal-title":"J. Pain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/CCO.0000000000000629","article-title":"Epidemiology of head and neck cancers: An update","volume":"32","year":"2020","journal-title":"Curr. Opin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Scheff, N.N., Bhattacharya, A., Dowse, E., Dang, R.X., Dolan, J.C., Wang, S., Kim, H., Albertson, D.G., and Schmidt, B.L. (2018). Neutrophil-Mediated Endogenous Analgesia Contributes to Sex Differences in Oral Cancer Pain. Front. Integr. Neurosci., 12.","DOI":"10.3389\/fnint.2018.00052"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.4103\/sja.SJA_162_17","article-title":"The burden of chronic pain after major head and neck tumor therapy","volume":"11","author":"Terkawi","year":"2017","journal-title":"Saudi J. Anaesth."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1364557032000119616","article-title":"Scoping studies: Towards a methodological framework","volume":"8","author":"Arksey","year":"2005","journal-title":"Int. J. Soc. Res. Methodol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1748-5908-5-69","article-title":"Scoping studies: Advancing the methodology","volume":"5","author":"Levac","year":"2010","journal-title":"Implement. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Yang, Y., Zhang, P., and Li, W. (2017). Comparison of orofacial pain of patients with different stages of precancer and oral cancer. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-00370-x"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/papr.12609","article-title":"Methadone versus Fentanyl in Patients with Radiation-Induced Nociceptive Pain with Head and Neck Cancer: A Randomized Controlled Noninferiority Trial","volume":"18","author":"Haumann","year":"2018","journal-title":"Pain Pract."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"101924","DOI":"10.1016\/j.jormas.2024.101924","article-title":"After 4 years of survival, patients treated for an oral or oropharyngeal cancer have more neurosensorial disorders than chronic pain and a better quality of life","volume":"125","author":"Ouadghiri","year":"2024","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s10266-009-0107-6","article-title":"Pain is associated with an endophytic cancer growth pattern in patients with oral squamous cell carcinoma before treatment","volume":"98","author":"Sato","year":"2010","journal-title":"Odontology"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ye, Y., Cardoso, D.M., Kayahara, G.M., and Bernab\u00e9, D.G. (2023). A pilot study to improve pain phenotyping in head and neck cancer patients. Front. Pain Res., 4.","DOI":"10.3389\/fpain.2023.1146667"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4103\/jhnps.jhnps_15_23","article-title":"Effect of Multicomponent Exercise Program on Temporomandibular Joint Dysfunction in Oral Cancer Survivors","volume":"11","author":"Shinde","year":"2023","journal-title":"J. Head Neck Physicians Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1515\/sjpain-2020-0067","article-title":"Pain management in patients undergoing radiation therapy for head and neck cancer\u2014A descriptive study","volume":"21","author":"Schaller","year":"2020","journal-title":"Scand. J. Pain"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/00016357.2021.1991470","article-title":"The prevalence and symptoms of temporomandibular disorders in head and neck cancer patients","volume":"80","author":"Saghafi","year":"2022","journal-title":"Acta Odontol. Scand."},{"key":"ref_27","first-page":"2891","article-title":"Myofascial pain, widespread pressure hypersensitivity, and hyperalgesia in the face, neck, and shoulder regions, in survivors of head and neck cancer","volume":"28","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_28","first-page":"e1082","article-title":"Dental approach of orofacial pain in head and neck cancer patients","volume":"10","author":"Arantes","year":"2018","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1200\/JCO.18.00896","article-title":"Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial","volume":"37","author":"Jiang","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1758-3284-1-26","article-title":"Neuropathic and nociceptive pain in head and neck cancer patients receiving radiation therapy","volume":"1","author":"Epstein","year":"2009","journal-title":"Head Neck Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0885-3924(99)00070-6","article-title":"Pain and loss of function in head and neck cancer survivors","volume":"18","author":"Chua","year":"1999","journal-title":"J. Pain. Symptom Manag."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3897\/pharmacia.71.e113077","article-title":"Head and neck cancer pain","volume":"71","author":"Sarumpaet","year":"2024","journal-title":"Pharmacia"},{"key":"ref_33","first-page":"699","article-title":"Facial pain, health-related quality of life and trismus-related symptoms up to 5 years post-radiotherapy for head and neck cancer","volume":"31","author":"Aghajanzadeh","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.2147\/JPR.S411285","article-title":"Head and Neck Cancer-Related Pain: A Descriptive Analysis of the Pain Phenotypes","volume":"16","author":"Khawaja","year":"2023","journal-title":"J. Pain. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1002\/hed.27199","article-title":"Neuropathic pain prevalence and risk factors in head and neck cancer survivors","volume":"44","author":"Rojo","year":"2022","journal-title":"Head Neck"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1055\/a-1851-5017","article-title":"Not Simply a Structural Problem: Psychological Determinants of Headache in Patients with Tumors of the Sellar Region","volume":"130","author":"Siegel","year":"2022","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.oooo.2022.07.001","article-title":"Characteristics and prevalence of orofacial pain as an initial symptom of oral and oropharyngeal cancer and its impact on the patient\u2019s functionality and quality of life","volume":"134","author":"Vilarim","year":"2022","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_38","first-page":"334","article-title":"Quality of life, craniomandibular function, and psychosocial factors related to pain and movement in patients with head and neck cancer","volume":"32","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"104612","DOI":"10.1016\/j.jpain.2024.104612","article-title":"Radiation-induced Chronic Pain Plagues Head and Neck Cancer Survivors: A Cross-sectional Analysis From the Cohort in Radiotherapy-related Nervous System Complications","volume":"25","author":"Zuo","year":"2024","journal-title":"J. Pain"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1002\/hed.26859","article-title":"Mechanisms of pain and their manifestations in head and neck cancer: Importance of classifying pain subtypes","volume":"43","author":"Lou","year":"2021","journal-title":"Head Neck"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/odi.13701","article-title":"Prevalence of pain in oral cancer: A retrospective study","volume":"27","author":"Khawaja","year":"2021","journal-title":"Oral Dis."},{"key":"ref_42","first-page":"2010","article-title":"Oral mucositis-related neuropathic pain in head and neck cancer patients receiving radiotherapy or chemo-radiotherapy. A prospective study","volume":"26","author":"Kouri","year":"2021","journal-title":"J. BUON."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.anorl.2020.03.004","article-title":"Neuropathic pain at diagnosis of head and neck squamous cell carcinoma","volume":"137","author":"Salwey","year":"2020","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9675654","DOI":"10.1155\/2019\/9675654","article-title":"Characteristics of Chronic Pain among Head and Neck Cancer Patients Treated with Radiation Therapy: A Retrospective Study","volume":"2019","author":"Kallurkar","year":"2019","journal-title":"Pain. Res. Manag."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1177\/0003489417723034","article-title":"Longitudinal Perioperative Pain Assessment in Head and Neck Cancer Surgery","volume":"126","author":"Buchakjian","year":"2017","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/0194599814521762","article-title":"Craniofacial pain secondary to occult head and neck tumors","volume":"150","author":"Starkman","year":"2014","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"143829","DOI":"10.1100\/2012\/143829","article-title":"Headache as the sole symptom of nasopharyngeal carcinoma and its clinical implications","volume":"2012","author":"Lee","year":"2012","journal-title":"Sci. World J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.pain.2011.02.009","article-title":"Orofacial pain onset predicts transition to head and neck cancer","volume":"152","author":"Lam","year":"2011","journal-title":"Pain"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1177\/014107680309600804","article-title":"Identifying neuropathic pain in patients with head and neck cancer: Use of the Leeds Assessment of Neuropathic Symptoms and Signs Scale","volume":"96","author":"Potter","year":"2003","journal-title":"J. R. Soc. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/1097-0142(19920701)70:1<178::AID-CNCR2820700128>3.0.CO;2-E","article-title":"Types and causes of pain in cancer of the head and neck","volume":"70","author":"Vecht","year":"1992","journal-title":"Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2147\/JPR.S155070","article-title":"Radiation-induced neuropathic pain successfully treated with systemic lidocaine administration","volume":"11","author":"Doo","year":"2018","journal-title":"J. Pain. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1200\/JCO.2013.52.4629","article-title":"Pain in cancer survivors","volume":"32","author":"Glare","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Byrd, H.F., and Kohutek, Z.A. (Oral Dis., 2024). Painful Realities: Navigating the Complexities of Head and Neck Cancer Pain, Oral Dis., Epub ahead of print.","DOI":"10.1111\/odi.15150"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3332\/ecancer.2020.1133","article-title":"Radiation-induced neuropathies in head and neck cancer: Prevention and treatment modalities","volume":"14","author":"Azzam","year":"2020","journal-title":"Ecancermedicalscience"},{"key":"ref_56","first-page":"pnaf051","article-title":"Prevalence and characteristics of persistent pain among head and neck cancer survivors: A systematic review and meta-analysis","volume":"28","year":"2025","journal-title":"Pain Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/AJP.0000000000000838","article-title":"Which Psychological Factors Are Involved in the Onset and\/or Persistence of Musculoskeletal Pain? An Umbrella Review of Systematic Reviews and Meta-Analyses of Prospective Cohort Studies","volume":"36","year":"2020","journal-title":"Clin. J. Pain"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Doan, L.V., Yoon, J., Chun, J., Perez, R., and Wang, J. (2023). Pain associated with breast cancer: Etiologies and therapies. Front. Pain Res., 4.","DOI":"10.3389\/fpain.2023.1182488"},{"key":"ref_59","unstructured":"(2018). Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia., 38, 1\u2013211."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jpain.2017.11.006","article-title":"Dimensionality and Reliability of the Central Sensitization Inventory in a Pooled Multicountry Sample","volume":"19","author":"Neblett","year":"2018","journal-title":"J. Pain."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neucli.2020.11.002","article-title":"Conditioned pain modulation-A comprehensive review","volume":"51","author":"Ramaswamy","year":"2021","journal-title":"Neurophysiol. Clin."},{"key":"ref_62","first-page":"rapm-2025-106553","article-title":"Transnasal spread of bupivacaine into the pterygopalatine fossa following endoscopically assisted cotton swab placement: A cadaveric study","volume":"26","author":"Jerman","year":"2025","journal-title":"Reg. Anesth. Pain Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/16\/5722\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:26:11Z","timestamp":1760034371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/16\/5722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":62,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jcm14165722"],"URL":"https:\/\/doi.org\/10.3390\/jcm14165722","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]}}}