{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:23:29Z","timestamp":1776378209290,"version":"3.51.2"},"reference-count":45,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Non-small-cell lung cancer (NSCLC) is a widespread and aggressive form of cancer, and in cases of its occurrence, accurate diagnosis and precise staging play a crucial role in determining treatment and estimating prognosis. Flexible bronchoscopy (FB) is a minimally invasive method used to assess the local and regional extent of the disease. FB facilitates the identification of endobronchial lesions and the collection of biopsy samples for histopathological diagnosis. It also enables the evaluation of regional lymph node involvement via advanced techniques such as endobronchial ultrasound with fine-needle aspiration (EBUS-TBNA). This method has high sensitivity and specificity, reducing the need for more invasive interventions like mediastinoscopy. The integration of endobronchial ultrasound (EBUS) has revolutionized NSCLC staging by providing detailed images and guiding biopsies of suspicious lymph nodes. Additionally, FB is valuable in staging the extent of primary tumor growth, providing critical information about the invasion of adjacent structures. In conclusion, FB, supported by advanced technologies, is important for the staging of NSCLC, improving medical practice and patient prognosis.<\/jats:p>","DOI":"10.3390\/jcm14165773","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T10:33:42Z","timestamp":1755254022000},"page":"5773","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Flexible Bronchoscopy and Non-Small-Cell Lung Cancer Staging: A Narrative Review of Modern Techniques for Optimized Clinical Decision-Making"],"prefix":"10.3390","volume":"14","author":[{"given":"Simona-Maria","family":"Ro\u0219u","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy, 200349 Craiova, Romania"},{"name":"Department of Pneumology, \u201cMarius Nasta\u201d Institute for Pneumology, 050159 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denisa Maria","family":"Mitroi","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9976-2256","authenticated-orcid":false,"given":"Oana Maria","family":"Catan\u0103","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-6969","authenticated-orcid":false,"given":"Viorel","family":"Biciu\u0219c\u0103","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorina Ionelia","family":"Stan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9240-922X","authenticated-orcid":false,"given":"Beatrice","family":"Mahler","sequence":"additional","affiliation":[{"name":"Department of Pneumology, \u201cMarius Nasta\u201d Institute for Pneumology, 050159 Bucharest, Romania"},{"name":"Department of Pneumology Faculty of Medicine, University of Medicine and Pharmacy Carol Davila of Bucharest, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana-Andreea","family":"Parliteanu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, \u201cTitu Maiorescu\u201d University, 040051 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4039-0811","authenticated-orcid":false,"given":"Adina Andreea","family":"Mirea","sequence":"additional","affiliation":[{"name":"Department of Oral-Dental Prevention, University of Medicine and Pharmacy, 200349 Craiova, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8409-5904","authenticated-orcid":false,"given":"Mara Amalia","family":"B\u0103lteanu","sequence":"additional","affiliation":[{"name":"Department of Pneumology, \u201cMarius Nasta\u201d Institute for Pneumology, 050159 Bucharest, Romania"},{"name":"Department of Pneumology, Faculty of Medicine, \u201cTitu Maiorescu\u201d University, 040051 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"ref_1","first-page":"33588","article-title":"Cancer statistics for the year 2020: An overview","volume":"5","author":"Ferlay","year":"2021","journal-title":"Int. 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