{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:37:55Z","timestamp":1760060275633,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Victor Babes, University of Medicine and Pharmacy, Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Chronic low-grade inflammation drives cardiometabolic risk; functional SNPs may influence individual cytokine and hematologic phenotypes. We investigated genotype-specific relationships between circulating immuno-inflammatory biomarkers and routine blood indices in apparently healthy adults. Methods: In this cross-sectional study, 155 fasting volunteers (26\u201372 years) were genotyped for IL1RN rs1149222 and TNF-proximal rs2071645. Serum IL-1\u03b2, TNF-\u03b1, oxidized LDL (oxLDL) and C-reactive protein (CRP) were quantified by ELISA, and complete blood counts were recorded simultaneously. Genotype effects were tested with ANOVA\/Kruskal\u2013Wallis; Spearman correlations and age-, sex-, BMI-adjusted linear models explored genotype-stratified associations. Results: Among 155 adults, IL1RN rs1149222 significantly affected IL-1\u03b2 (TT &gt; TG \u2248 GG; ANOVA p = 0.042) and oxLDL (overall p = 0.036), with the clearest difference between heterozygotes and major-allele homozygotes. The same variant produced a modest fall in erythrocyte count and hemoglobin restricted to heterozygotes (RBC p = 0.036; Hb p = 0.041). TNF-proximal rs2071645 strongly raised TNF-\u03b1 (GG &gt; GA &gt; AA; p &lt; 0.0001) and led to a moderate oxLDL increase, driven by GA versus AA carriers (pairwise p = 0.013), while leaving red-cell indices and CRP unchanged. Baseline leukocyte counts, differentials and derived ratios showed no genotype dependence, and multivariable models revealed no epistatic interaction between the two loci. Conclusions: IL1RN rs1149222 and TNF-related rs2071645 generate two independent inflammatory signatures\u2014an IL-1\u03b2-oxidative axis linked to mild erythropoietic suppression and a TNF-lipid axis without hematologic shift. Integrating targeted genotyping with inexpensive hematologic ratios may refine early risk stratification and guide tailored preventive strategies in ostensibly healthy populations.<\/jats:p>","DOI":"10.3390\/jcm14165792","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T14:24:28Z","timestamp":1755267868000},"page":"5792","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlations Between Immuno-Inflammatory Biomarkers and Hematologic Indices Stratified by Immunologic SNP Genotypes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6793-5361","authenticated-orcid":false,"given":"Simona-Alina","family":"Abu-Awwad","sequence":"first","affiliation":[{"name":"Scientific Research Department, \u201cPius Brinzeu\u201d Emergency Clinical County Hospital, Bld Liviu Rebreanu, No. 156, 300723 Timisoara, Romania"},{"name":"Department XII, Discipline of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"},{"name":"Scientific Research Department, Orthopedics Medical Center- Private Hospital, Aries Street No. 7, 300579 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6185-0960","authenticated-orcid":false,"given":"Ahmed","family":"Abu-Awwad","sequence":"additional","affiliation":[{"name":"Scientific Research Department, \u201cPius Brinzeu\u201d Emergency Clinical County Hospital, Bld Liviu Rebreanu, No. 156, 300723 Timisoara, Romania"},{"name":"Scientific Research Department, Orthopedics Medical Center- Private Hospital, Aries Street No. 7, 300579 Timisoara, Romania"},{"name":"Department XV\u2014Discipline of Orthopedics\u2014Traumatology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"},{"name":"Research Center University Professor Doctor Teodor Sora, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona Sorina","family":"Farcas","sequence":"additional","affiliation":[{"name":"Discipline of Genetics, Department of Microscopic Morphology, Genomic Medicine Centre \u201cVictor Babes\u201d, University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Annemari","family":"Popa","sequence":"additional","affiliation":[{"name":"Discipline of Genetics, Department of Microscopic Morphology, Genomic Medicine Centre \u201cVictor Babes\u201d, University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Tutac","sequence":"additional","affiliation":[{"name":"Toxicology and Molecular Biology Department, \u201cPius Brinzeu\u201d Clinical Emergency County Hospital, 300723 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iuliana Maria","family":"Zaharia","sequence":"additional","affiliation":[{"name":"Dr Victor Babe\u0219 Clinical Hospital for Infectious Diseases and Pneumophthisiology, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Alexandrina","family":"Goina","sequence":"additional","affiliation":[{"name":"Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Mihailescu","sequence":"additional","affiliation":[{"name":"Discipline of Genetics, Department of Microscopic Morphology, Genomic Medicine Centre \u201cVictor Babes\u201d, University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-4234","authenticated-orcid":false,"given":"Nicoleta","family":"Andreescu","sequence":"additional","affiliation":[{"name":"Discipline of Genetics, Department of Microscopic Morphology, Genomic Medicine Centre \u201cVictor Babes\u201d, University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e70020","DOI":"10.1111\/eci.70020","article-title":"Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment","volume":"55","author":"Arnold","year":"2025","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Xiang, Y., Zhang, M., Jiang, D., Su, Q., and Shi, J. (2023). The role of inflammation in autoimmune disease: A therapeutic target. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1267091"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Plows, J.F., Stanley, J.L., Baker, P.N., Reynolds, C.M., and Vickers, M.H. (2018). The Pathophysiology of Gestational Diabetes Mellitus. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113342"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Torres-Torres, J., Espino-Y-Sosa, S., Martinez-Portilla, R., Borboa-Olivares, H., Estrada-Gutierrez, G., Acevedo-Gallegos, S., Ruiz-Ramirez, E., Velasco-Espin, M., Cerda-Flores, P., and Ramirez-Gonzalez, A. (2024). A Narrative Review on the Pathophysiology of Preeclampsia. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147569"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cytogfr.2024.07.007","article-title":"Inflammatory mechanisms of preterm labor and emerging anti-inflammatory interventions","volume":"78","author":"Habelrih","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Bhol, N.K., Bhanjadeo, M.M., Singh, A.K., Dash, U.C., Ojha, R.R., Majhi, S., Duttaroy, A.K., and Jena, A.B. (2024). The interplay between cytokines, inflammation, and antioxidants: Mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds. Biomed. Pharmacother., 178.","DOI":"10.1016\/j.biopha.2024.117177"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Mosalmanzadeh, N., and Pence, B.D. (2024). Oxidized Low-Density Lipoprotein and Its Role in Immunometabolism. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252111386"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1530\/VB-22-0009","article-title":"OxLDL induces the release of IL-1\u03b2 from primed human endothelial and smooth muscle cells via different caspase -1-dependent mechanisms","volume":"4","author":"Almansouri","year":"2022","journal-title":"Vasc. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Oh, K., Yuk, M., Yang, S., Youn, J., Dong, Q., Wang, Z., and Song, N. (2025). A genome-wide association study of high-sensitivity C-reactive protein in a large Korean population highlights its genetic relationship with cholesterol metabolism. Sci. Rep., 15.","DOI":"10.1038\/s41598-024-84466-1"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Konieczny, M.J., Omarov, M., Zhang, L., Malik, R., Richardson, T.G., Baumeister, S.E., Bernhagen, J., Dichgans, M., and Georgakis, M.K. (2025). The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases. Commun. Biol., 8.","DOI":"10.1038\/s42003-025-07453-w"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41590-023-01588-w","article-title":"Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets","volume":"24","author":"Zhao","year":"2023","journal-title":"Nat. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wang, S., Liang, T., and Zhang, C. (2025). The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-90995-0"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/jmedsci.jmedsci_110_23","article-title":"Polymorphism of Toll-like Receptor 4 Is Correlated with an Increased Risk of Mortality of Hemodialysis Patients: A Retrospective Cohort Study in Taiwanese","volume":"44","author":"Lee","year":"2024","journal-title":"J. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Cariello, M., Peres, C., Zerlotin, R., Porru, E., Sabb\u00e0, C., Roda, A., and Moschetta, A. (2017). Long-term Administration of Nuclear Bile Acid Receptor FXR Agonist Prevents Spontaneous Hepatocarcinogenesis in Abcb4\u2212\/\u2212 Mice. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-11549-7"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4254\/wjh.v8.i8.401","article-title":"Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4(-\/-) mouse model","volume":"8","author":"Reiter","year":"2016","journal-title":"World J. Hepatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/tjem.tjem_198_23","article-title":"Unraveling the clinical significance and prognostic value of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation response index, and delta neutrophil index: An extensive literature review","volume":"24","author":"Islam","year":"2024","journal-title":"Turk. J. Emerg. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Buonacera, A., Stancanelli, B., Colaci, M., and Malatino, L. (2022). Neutrophil to Lymphocyte Ratio: An Emerging Marker of the Relationships between the Immune System and Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23073636"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Aslan Sirakaya, H., Sipahioglu, H., Cetinkaya, A., and Aydin, K. (2025). Relationship Between Inflammatory Markers (IL-6, Neutrophil-Lymphocyte Ratio, and C-Reactive Protein-Albumin Ratio) and Diabetic Ketoacidosis Severity: Correlation with Clinical Outcomes. Medicina, 61.","DOI":"10.3390\/medicina61020321"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s43162-024-00284-x","article-title":"Monocyte lymphocyte ratio, IL 6, and their association with increased carotid intima-media thickness as simple predictive markers for nephropathy in Egyptian diabetic patients","volume":"36","author":"Ibrahim","year":"2024","journal-title":"Egypt. J. Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"101640","DOI":"10.1016\/j.jacadv.2025.101640","article-title":"Chronic Inflammatory-Related Disease and Cardiovascular Disease in MESA","volume":"4","author":"Manning","year":"2025","journal-title":"JACC Adv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"24272","DOI":"10.1074\/jbc.273.37.24272","article-title":"Secretory interleukin-1 receptor antagonist gene expression requires both a PU.1 and a novel composite NF-kappaB\/PU.1\/GA-binding protein binding site","volume":"273","author":"Smith","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.4049\/jimmunol.1002402","article-title":"The IL1RN promoter rs4251961 correlates with IL-1 receptor antagonist concentrations in human infection and is differentially regulated by GATA-1","volume":"186","author":"Carrol","year":"2011","journal-title":"J. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s13075-024-03436-0","article-title":"Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls","volume":"26","author":"Gaal","year":"2024","journal-title":"Arthritis Res. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbrc.2012.07.011","article-title":"Oxidized low-density lipoprotein induces secretion of interleukin-1\u03b2 by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation","volume":"425","author":"Jiang","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00011-013-0667-3","article-title":"OxLDL-induced IL-1 beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation","volume":"63","author":"Liu","year":"2014","journal-title":"Inflamm. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Verma, D., S\u00e4rndahl, E., Andersson, H., Eriksson, P., Fredrikson, M., J\u00f6nsson, J.I., Lerm, M., and S\u00f6derkvist, P. (2012). The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1\u03b2 and IL-18 production. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034977"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/jn\/137.8.1846","article-title":"Interleukin1beta genetic polymorphisms interact with polyunsaturated fatty acids to modulate risk of the metabolic syndrome","volume":"137","author":"Shen","year":"2007","journal-title":"J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/CCM.0b013e3181b42af0","article-title":"Association between tumor necrosis factor-alpha promoter -308 A\/G polymorphism and susceptibility to sepsis and sepsis mortality: A systematic review and meta-analysis","volume":"38","author":"Teuffel","year":"2010","journal-title":"Crit. Care Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9113","DOI":"10.1128\/MCB.20.24.9113-9119.2000","article-title":"Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region","volume":"20","author":"Udalova","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e21851","DOI":"10.1097\/MD.0000000000021851","article-title":"Association of TNF-\u03b1-308G\/A, -238G\/A, -863C\/A, -1031T\/C, -857C\/T polymorphisms with periodontitis susceptibility: Evidence from a meta-analysis of 52 studies","volume":"99","author":"Xu","year":"2020","journal-title":"Medicine"},{"key":"ref_32","first-page":"1205","article-title":"Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients","volume":"9","author":"Majetschak","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Rosales, C. (2018). Neutrophil: A Cell with Many. Roles in Inflammation or Several Cell Types?. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.00113"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/01.ATV.14.1.47","article-title":"Oxidized LDL induces monocytic cell expression of interleukin-8, a chemokine with T-lymphocyte chemotactic activity","volume":"14","author":"Terkeltaub","year":"1994","journal-title":"Arterioscler. Thromb."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"10275","DOI":"10.1074\/jbc.M116.770974","article-title":"Interleukin-1\u03b2 (IL-1\u03b2) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein \u03b4 (C\/EBP\u03b4) expression in hepatocytes","volume":"292","author":"Kanamori","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bandach, I., Segev, Y., and Landau, D. (2021). Experimental modulation of Interleukin 1 shows its key role in chronic kidney disease progression and anemia. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-85778-2"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Poznyak, A.V., Nikiforov, N.G., Markin, A.M., Kashirskikh, D.A., Myasoedova, V.A., Gerasimova, E.V., and Orekhov, A.N. (2021). Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.613780"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Thomas, C., Leleu, D., and Masson, D. (2022). Cholesterol and HIF-1\u03b1: Dangerous Liaisons in Atherosclerosis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.868958"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/s42255-021-00470-z","article-title":"Metabolic Messengers: Tumour necrosis factor","volume":"3","author":"Sethi","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s12013-024-01522-3","article-title":"Comparative Effects of Tumor Necrosis Factor Alpha, Lipopolysaccharide, and Palmitate on Mitochondrial Dysfunction in Cultured 3T3-L1 Adipocytes","volume":"83","author":"Jack","year":"2025","journal-title":"Cell Biochem. Biophys."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s00109-023-02379-4","article-title":"Soluble LDL-receptor is induced by TNF-\u0152\u00b1 and inhibits hepatocytic clearance of LDL-cholesterol","volume":"101","author":"Zegeye","year":"2023","journal-title":"J. Mol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.stem.2019.05.019","article-title":"TNF-\u03b1 Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration","volume":"25","author":"Yamashita","year":"2019","journal-title":"Cell Stem Cell"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Freitas, R.D.S., de Souza Silva, C.M., Ferreira Fratelli, C., Ramos de Lima, L., Morato Stival, M., Schwerz Funghetto, S., Rodrigues da Silva, I.C., and Vieira de Andrade, R. (2024). IL-10 and IL-1\u03b2 Serum Levels, Genetic Variants, and Metabolic Syndrome: Insights into Older Adults\u2019 Clinical Characteristics. Nutrients, 16.","DOI":"10.20944\/preprints202403.0302.v1"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Nani, A., and Tehami, W. (2023). Targeting inflammasome pathway by polyphenols as a strategy for pancreatitis, gastrointestinal and liver diseases management: An updated review. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1157572"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Su, L., Xu, C., Huang, H., Zhang, P., Wang, J., Ouyang, X., Yang, X., and Ye, J. (2024). Effects of tumor necrosis factor-alpha inhibitors on lipid profiles in patients with psoriasis: A systematic review and meta-analysis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1354593"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Dang, P., Wang, F., and Yu, H. (2024). Prognostic potential of neutrophil-to-lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio in acute myocardial infarction patients combined with chronic obstructive pulmonary disease. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1401634"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/16\/5792\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:28:43Z","timestamp":1760034523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/16\/5792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,15]]},"references-count":46,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jcm14165792"],"URL":"https:\/\/doi.org\/10.3390\/jcm14165792","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,8,15]]}}}