{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:42:16Z","timestamp":1782301336817,"version":"3.54.5"},"reference-count":23,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: The impact of surgical resection for chronic pancreatitis on subsequent endocrine outcomes remains unclear. Methods: A single-center analysis of patients with chronic pancreatitis who underwent either a parenchymal-preserving surgery (PPS) or a total pancreatectomy (TP) with\/without islet autotransplantation (IAT) between 2018 and 2024 was performed. Preoperative and postoperative changes in hemoglobin A1C (HbA1C) and long-acting insulin dose were compared. Univariate and multivariate analysis was performed to identify factors associated with 1-year insulin independence. Results: A total of 104 patients underwent surgery for chronic pancreatitis between 2018 and 2024. A total of 35 (33.7%) patients underwent TPIAT, 8 (7.7%) underwent TP, and 61 (58.7%) underwent PPS (n = 18 Whipple, n = 38 distal pancreatectomy, n = 5 drainage procedure). Median HbA1C increased after surgery (5.7% vs. 6.8%, p &lt; 0.001). The majority of patients (n = 73, 70.2%) were discharged postoperatively without any basal insulin requirement. Of the 31 patients discharged on basal insulin, 18 patients (58.1%) were not on basal insulin preoperatively; the other 13 patients (41.9%) that were on basal insulin preoperatively had a median change in their postoperative basal insulin dose of \u22125 units [IQR: \u221212\u2013\u22121]. A total of 46 patients (52.3%) were insulin independent at one year, with PPS more favorable than TPIAT (47.6% vs. 21.7%, p &lt; 0.001) and less likely to have been on preoperative basal insulin. Conclusions: Surgery for chronic pancreatitis resulted in an increase in HbA1C postoperatively; however, diabetes remained well-controlled as the majority of patients remained off basal insulin at one year from surgery. PPS patients were more likely to be insulin-independent.<\/jats:p>","DOI":"10.3390\/jcm14165817","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T15:34:53Z","timestamp":1755531293000},"page":"5817","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pancreatogenic Type 3c Diabetes After Major Pancreatic Resections for Chronic Pancreatitis: A Single-Center Experience of More than 100 Surgical Cases"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6315-7728","authenticated-orcid":false,"given":"Dhruv J.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Medicine, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5096-9980","authenticated-orcid":false,"given":"Alexandra D.","family":"Nelson","sequence":"additional","affiliation":[{"name":"School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-760X","authenticated-orcid":false,"given":"Melissa E.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation, Department of Surgery, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-7309","authenticated-orcid":false,"given":"Morgan S.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-0973","authenticated-orcid":false,"given":"Chirag S.","family":"Desai","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation, Department of Surgery, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA"},{"name":"Department of Surgery, School of Medicine, University of North Carolina, 4001 Burnett Womack Building, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/ueg2.12694","article-title":"Surgical Management of Chronic Pancreatitis: A Narrative Review","volume":"13","author":"Dankha","year":"2025","journal-title":"United Eur. 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