{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:19:27Z","timestamp":1789593567310,"version":"build-2803163510"},"reference-count":68,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Platelet-rich plasma (PRP) therapy is a non-invasive, autologous treatment with regenerative potential in gynaecology beyond fertility applications. This review evaluates PRP in non-fertility-related gynaecological conditions affecting women\u2019s quality of life (QoL). Methods: Following PRISMA-ScR guidelines, we searched Embase, CINAHL, Web of Science, Scopus, CENTRAL, and MEDLINE for studies on PRP in conditions such as vulvar lichen sclerosus (VLS), vulvovaginal atrophy (VVA), sexual dysfunction (SD), stress urinary incontinence (SUI), and interstitial cystitis\/bladder pain syndrome (IC\/BPS). Of 3660 records screened, 43 studies (randomised controlled trials, quasi-experimental, cohort, and case series) were included. Results: PRP improved symptoms and QoL in several conditions, particularly VLS and SD, and was generally well tolerated with minor adverse effects (e.g., injection-site pain, transient discomfort). Evidence for abnormal uterine bleeding (AUB) and pelvic organ prolapse (POP) was inconclusive. Considerable heterogeneity in preparation protocols and outcome measures limited cross-study comparison. Conclusions: PRP shows promise as a minimally invasive therapy for certain gynaecological conditions. Standardisation of preparation and administration, along with large-scale RCTs, is needed to determine long-term efficacy and safety.<\/jats:p>","DOI":"10.3390\/jcm14165832","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T15:34:53Z","timestamp":1755531293000},"page":"5832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Application of Platelet-Rich Plasma in Gynaecologic Disorders: A Scoping Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3570-2499","authenticated-orcid":false,"given":"Nadia","family":"Willison","sequence":"first","affiliation":[{"name":"FBW Gynaecology Plus, Ashford, SA 5035, Australia"},{"name":"Discipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Behnia-Willison","sequence":"additional","affiliation":[{"name":"FBW Gynaecology Plus, Ashford, SA 5035, Australia"},{"name":"Discipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2844-4706","authenticated-orcid":false,"given":"Pouria","family":"Aryan","sequence":"additional","affiliation":[{"name":"FBW Gynaecology Plus, Ashford, SA 5035, Australia"},{"name":"Discipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-7565","authenticated-orcid":false,"given":"Zahra Ali","family":"Padhani","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia"},{"name":"Robinson Research Institute, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Mirzaei Damabi","sequence":"additional","affiliation":[{"name":"School of Public Health, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5000, Australia"},{"name":"Robinson Research Institute, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA 5006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran","family":"Nguyen","sequence":"additional","affiliation":[{"name":"FBW Gynaecology Plus, Ashford, SA 5035, Australia"},{"name":"Discipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Yi","sequence":"additional","affiliation":[{"name":"Departments of Medical and Surgical Gynecology, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rituparna","family":"Dutta","sequence":"additional","affiliation":[{"name":"FBW Gynaecology Plus, Ashford, SA 5035, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0945-2674","authenticated-orcid":false,"given":"Derek","family":"Abbott","sequence":"additional","affiliation":[{"name":"Discipline of Biomedical Engineering, School of EME, The University of Adelaide, Adelaide, SA 5005, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2955","DOI":"10.1007\/s10815-021-02328-5","article-title":"Autologous platelet-rich plasma treatment for moderate-severe Asherman syndrome: The first experience","volume":"38","author":"Aghajanova","year":"2021","journal-title":"J. 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