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Medical Talents\u201d Youth Development Program, Shanghai Municipal Health Commission Project","award":["82371040"],"award-info":[{"award-number":["82371040"]}]},{"name":"Outstanding Youth Medical Talents of Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program, Shanghai Municipal Health Commission Project","award":["82122017"],"award-info":[{"award-number":["82122017"]}]},{"name":"Outstanding Youth Medical Talents of Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program, Shanghai Municipal Health Commission Project","award":["81870642"],"award-info":[{"award-number":["81870642"]}]},{"name":"Outstanding Youth Medical Talents of Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program, Shanghai Municipal Health Commission Project","award":["81970780"],"award-info":[{"award-number":["81970780"]}]},{"name":"Outstanding Youth Medical Talents of Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program, Shanghai Municipal Health Commission Project","award":["81470613"],"award-info":[{"award-number":["81470613"]}]},{"name":"Outstanding Youth Medical Talents of Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program, Shanghai Municipal Health Commission Project","award":["81670835"],"award-info":[{"award-number":["81670835"]}]},{"name":"Outstanding Youth Medical Talents of Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program, Shanghai Municipal Health Commission Project","award":["23Y11909800"],"award-info":[{"award-number":["23Y11909800"]}]},{"name":"Outstanding Youth Medical Talents of Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program, Shanghai Municipal Health Commission Project","award":["2024ZZ1025"],"award-info":[{"award-number":["2024ZZ1025"]}]},{"name":"Outstanding Youth Medical Talents of Shanghai \u201cRising Stars of Medical Talents\u201d Youth Development Program, Shanghai Municipal Health Commission Project","award":["20244Z0015"],"award-info":[{"award-number":["20244Z0015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Although high myopia primarily affects the eyes, emerging evidence suggests that it is also associated with systemic inflammation and metabolic dysfunction. The liver plays a key role in metabolism and inflammation, and it may share pathological pathways with high myopia. However, no population studies have examined the relationship between high myopia and liver disease progression. This study used UK Biobank data to analyze the relationship between myopia severity and severe liver disease, as well as to determine whether inflammatory markers or metabolites mediate this link. Methods: A prospective cohort of 70,774 UK Biobank participants without severe liver disease at baseline was followed for 14.1 years. Myopia was categorized as emmetropia, low-to-moderate, or high based on refractive error. Cox proportional hazards models, stratified by aspartate aminotransferase (AST) level (\u226540 vs. &lt;40 U\/L), were used to assess liver disease risk, and mediation analyses were used to evaluate inflammatory markers and metabolites. Results: Among participants with AST levels of at least 40 U\/L, high myopia significantly increased liver fibrosis and cirrhosis risk (hazard ratio [HR] = 2.64, 95% confidence interval [CI] = 1.44\u20134.85, p = 0.002), exhibiting a dose-dependent trend (ptrend = 0.004). No association existed for AST &lt; 40 U\/L. C-reactive protein (CRP) partially mediated this link; no metabolites survived correction. Conclusions: High myopia is independently associated with an increased risk of liver fibrosis and cirrhosis in individuals with elevated AST, partially mediated by CRP-related inflammation. Refractive assessment may stratify liver disease risk in subclinical injury, warranting anti-inflammatory intervention research.<\/jats:p>","DOI":"10.3390\/jcm14165860","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:41:41Z","timestamp":1755603701000},"page":"5860","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High Myopia as a Risk Factor for Severe Liver Disease in Individuals with Liver Dysfunction: Evidence from a Prospective Cohort"],"prefix":"10.3390","volume":"14","author":[{"given":"Linge","family":"Jian","sequence":"first","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"},{"name":"NHC Key Laboratory of Myopia, Fudan University, Shanghai 200031, China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai 200031, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqian","family":"Huang","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"},{"name":"NHC Key Laboratory of Myopia, Fudan University, Shanghai 200031, China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai 200031, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Du","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"},{"name":"NHC Key Laboratory of Myopia, Fudan University, Shanghai 200031, China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai 200031, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"},{"name":"NHC Key Laboratory of Myopia, Fudan University, Shanghai 200031, China"},{"name":"Key Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai 200031, China"},{"name":"Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"ref_1","unstructured":"(2025, March 01). 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