{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:00Z","timestamp":1787028660333,"version":"build-2736575974"},"reference-count":35,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: Gonadotropin-releasing hormone (GnRH) antagonist protocols are preferred in polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF) as they provide the best combination of flexibility, acceptable outcomes, and safety. Numerous studies have compared outcomes between GnRH agonist long protocol and standard flexible antagonist protocol. However, there are scant studies investigating the effectiveness of antagonist administration from day 1 of ovarian stimulation in PCOS patients. Methods: We performed a retrospective cohort study to compare laboratory and clinical outcomes in IVF between standard flexible day 5\/day 6 versus day 1 GnRH antagonist protocol in PCOS patients. Results: Our data indicates significantly superior oocyte yield and top-quality embryo proportion in patients with antagonists from day 1. Cumulative clinical pregnancy rates also tended to be superior in this group. Conclusions: Our findings indicate that administration of GnRH antagonists from day 1 of stimulation in PCOS patients undergoing IVF may lead to superior results.<\/jats:p>","DOI":"10.3390\/jcm14165901","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T15:19:02Z","timestamp":1755789542000},"page":"5901","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimizing Ovarian Stimulation for IVF in PCOS Patients: A Novel Day 1 GnRH Antagonist Protocol"],"prefix":"10.3390","volume":"14","author":[{"given":"Sudarsan","family":"Ghosh Dastidar","sequence":"first","affiliation":[{"name":"GD Institute for Fertility Research, 36 A\/1 S.P. Mukherjee Road, Kolkata 700025, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9023-4473","authenticated-orcid":false,"given":"Biswanath","family":"Ghosh Dastidar","sequence":"additional","affiliation":[{"name":"GD Institute for Fertility Research, 36 A\/1 S.P. Mukherjee Road, Kolkata 700025, West Bengal, India"},{"name":"Department of Obstetrics and Gynecology & GDIFR-IPGMER Center of Excellence (COE) in Assisted Reproductive Technology (ART), Institute of Post-Graduate Medical Education and Research (IPGMER) & SSKM Hospital, 244 AJC Bose Road, Kolkata 700020, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Medicine, DD-18\/5\/1, Sector-1, Salt Lake, Kolkata 700064, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"National Institute of Technical Teachers\u2019 Training and Research, Falguni Road, FC Block, Sector 3, Salt Lake, Kolkata 700106, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/humupd\/dmw025","article-title":"The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global WHO guidance","volume":"22","author":"Balen","year":"2016","journal-title":"Hum. 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